Omilancor (BT-11)

Catalog No.S6419

For research use only.

Omilancor (BT-11) is an orally active lanthionine synthetase C-like 2 (LANCL2) binding compound for treating inflammatory bowel disease (IBD) (Kd value of 7.7 µM).

Omilancor (BT-11) Chemical Structure

CAS No. 1912399-75-7

Purity & Quality Control

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Biological Activity

Description Omilancor (BT-11) is an orally active lanthionine synthetase C-like 2 (LANCL2) binding compound for treating inflammatory bowel disease (IBD) (Kd value of 7.7 µM).
Targets
LANCL2 [1]
()
In vitro

In vitro measurement of cAMP in mouse splenocytes extracted from either WT or LANCL2−/− mice and treated with increasing doses of BT-11 demonstrates BT-11 stimulates cAMP production by activating the LANCL2 pathway[1].

In vivo

Oral treatment with BT-11 (8 mg/kg/day) ameliorates colitis in mice. Safety assessment in rats indicateds that Oral treatment with BT-11 at high doses has an excellent safety profile up to 1000 mg/kg/day. In a dextran sodium sulfate colitis mouse model, oral administration of BT-11 upregulates the expression of IL-10 and downregulates the expression of TNF-α mRNA. It also upregulates LANCL2 expression in the gastrointestinal tract[1].

Protocol (from reference)

Animal Research:

[1]

  • Animal Models: DSS-Induced Colitis (C57BL/6J or LANCL2−/− mice)
  • Dosages: 8 mg/kg/d
  • Administration: orogastric gavage (orally)

Solubility (25°C)

In vitro

DMSO 13 mg/mL
(24.59 mM)
Water Insoluble
Ethanol Insoluble

Chemical Information

Molecular Weight 528.56
Formula

C30H24N8O2

CAS No. 1912399-75-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1CN(CCN1C(=O)C2=CC=CC(=N2)C3=NC4=CC=CC=C4N3)C(=O)C5=CC=CC(=N5)C6=NC7=CC=CC=C7N6

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05057273 Not yet recruiting Drug: BT-11 (Omilancor)|Biological: adalimumab Crohn''s Disease Landos Biopharma Inc. November 2021 Phase 2
NCT03861143 Completed Drug: BT-11 (500 mg)|Drug: BT-11 (1000 mg)|Drug: Placebo Ulcerative Colitis Landos Biopharma Inc. August 14 2019 Phase 2

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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