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Omilancor (BT-11)

Omilancor (BT-11) is an orally active lanthionine synthetase C-like 2 (LANCL2) binding compound for treating inflammatory bowel disease (IBD) (Kd value of 7.7 µM).

Omilancor (BT-11) Chemical Structure

Omilancor (BT-11) Chemical Structure

CAS: 1912399-75-7

Purity & Quality Control

Batch: Purity: 99.05%
99.05

Omilancor (BT-11) Related Products

Biological Activity

Description Omilancor (BT-11) is an orally active lanthionine synthetase C-like 2 (LANCL2) binding compound for treating inflammatory bowel disease (IBD) (Kd value of 7.7 µM).
Targets
LANCL2 [1]
In vitro
In vitro

In vitro measurement of cAMP in mouse splenocytes extracted from either WT or LANCL2−/− mice and treated with increasing doses of BT-11 demonstrates BT-11 stimulates cAMP production by activating the LANCL2 pathway[1].
In Vivo
In vivo

Oral treatment with BT-11 (8 mg/kg/day) ameliorates colitis in mice. Safety assessment in rats indicateds that Oral treatment with BT-11 at high doses has an excellent safety profile up to 1000 mg/kg/day. In a dextran sodium sulfate colitis mouse model, oral administration of BT-11 upregulates the expression of IL-10 and downregulates the expression of TNF-α mRNA. It also upregulates LANCL2 expression in the gastrointestinal tract[1].
Animal Research Animal Models DSS-Induced Colitis (C57BL/6J or LANCL2−/− mice)
Dosages 8 mg/kg/d
Administration orogastric gavage (orally)

Chemical Information & Solubility

Molecular Weight 528.56 Formula

C30H24N8O2
CAS No. 1912399-75-7 SDF --
Smiles C1CN(CCN1C(=O)C2=CC=CC(=N2)C3=NC4=CC=CC=C4N3)C(=O)C5=CC=CC(=N5)C6=NC7=CC=CC=C7N6
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 4 mg/mL ( (7.56 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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