Home PI3K/Akt/mTOR AMPK activator O-304

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O-304 AMPK activator

Cat.No.S0795

O-304 (O-304X) is an orally available pan-activator of AMPK activated protein kinase (AMPK). This compound exhibits a great potential as a novel drug to treat type 2 diabetes (T2D) and associated cardiovascular complications.
O-304 AMPK activator Chemical Structure

Chemical Structure

Molecular Weight: 380.25

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Quality Control

Batch: S079501 DMSO]20 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.56%
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  • COA
  • NMR
  • HPLC
  • SDS
  • Datasheet
99.56

Solubility

In vitro
Batch:

DMSO : 20 mg/mL (52.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

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Mass Concentration Volume Molecular Weight
Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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g
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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO
%
% Tween 80
% ddH2O
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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 380.25 Formula

C16H11Cl2N3O2S

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 1261289-04-6 -- Storage of Stock Solutions

Synonyms O-304X Smiles C1=CC(=CC=C1CN2C(=O)N=C(S2)NC(=O)C3=CC=C(C=C3)Cl)Cl

Mechanism of Action

Targets/IC50/Ki
AMPK
References

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