Ombitasvir (ABT-267)

Catalog No.S5403

For research use only.

Ombitasvir (ABT-267) is an inhibitor of the HCV non-structural protein 5A with antiviral activity.

Ombitasvir (ABT-267) Chemical Structure

CAS No. 1258226-87-7

Selleck's Ombitasvir (ABT-267) has been cited by 3 Publications

Purity & Quality Control

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Biological Activity

Description Ombitasvir (ABT-267) is an inhibitor of the HCV non-structural protein 5A with antiviral activity.
NS5A [1]
In vitro

Ombitasvir (ABT-267) is a hepatitis C virus (HCV) NS5A inhibitor with picomolar potency, pan-genotypic activity, and 50% effective concentrations (EC50s) of 0.82 to 19.3 pM against HCV genotypes 1 to 5 and 366 pM against genotype 6a. Ombitasvir has EC50s of 14.1 and 5.0 pM against genotype 1a-H77 and 1b-Con1 subgenomic replicons, respectively[1].

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 894.11


CAS No. 1258226-87-7
Storage 3 years -20°C powder
2 years -80°C in solvent

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02581020 Completed -- Hepatitis C Virus AbbVie January 14 2016 --
NCT02534870 Completed Drug: ABT-450/r/ABT-267|Drug: ABT-333 Healthy Volunteer AbbVie September 2015 Phase 1
NCT02734173 Completed Drug: ABT450r-ABT267-ABT333 +/- Ribavirin Hepatitis C Ottawa Hospital Research Institute|AbbVie July 2015 Phase 4
NCT01911845 Completed Drug: ABT-450/r/ABT-267|Drug: ABT-333|Drug: Ribavirin (RBV) Chronic Hepatitis C Infection|Chronic Hepatitis C AbbVie April 2013 Phase 2

(data from, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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