O6-Benzylguanine

Catalog No.S3658 Synonyms: O6-BG

O6-Benzylguanine Chemical Structure

Molecular Weight(MW): 241.25

O6-Benzylguanine (O6-BG) is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.

Size Price Stock Quantity  
USD 97 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Purity & Quality Control

Choose Selective Transferase Inhibitors

Biological Activity

Description O6-Benzylguanine (O6-BG) is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.
Targets
AGT [1]
()
In vitro

Pirenzepine is a antimuscarinic agent which, unlike classic anticholinergic agents, inhibits gastric acid secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular and urinary functions[1].

Protocol

Solubility (25°C)

In vitro DMSO 48 mg/mL (198.96 mM)
Ethanol 12 mg/mL (49.74 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 241.25
Formula

C12H11N5O

CAS No. 19916-73-5
Storage powder
in solvent
Synonyms O6-BG

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT00275002 Completed Drug: O6-benzylguanine|Drug: temozolomide Brain and Central Nervous System Tumors National Cancer Institute (NCI) February 2006 Phase 2
NCT00086970 Terminated Drug: ifosfamide|Drug: O6-benzylguanine Unspecified Adult Solid Tumor Protocol Specific National Cancer Institute (NCI) June 2004 Phase 1
NCT00613093 Completed Drug: Temodar and O6-Benzylguanine (BG) Glioblastoma Multiforme|Anaplastic Glioma Duke University|Keryx / AOI Pharmaceuticals Inc.|National Institutes of Health (NIH) October 2002 Phase 2
NCT00005981 Completed Drug: O6-benzylguanine|Drug: carmustine Colorectal Cancer Case Comprehensive Cancer Center|National Cancer Institute (NCI) June 2000 Phase 2
NCT00004072 Completed Drug: O6-benzylguanine|Drug: carmustine Multiple Myeloma and Plasma Cell Neoplasm Case Comprehensive Cancer Center|National Cancer Institute (NCI) September 1999 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Transferase Signaling Pathway Map

Tags: buy O6-Benzylguanine | O6-Benzylguanine supplier | purchase O6-Benzylguanine | O6-Benzylguanine cost | O6-Benzylguanine manufacturer | order O6-Benzylguanine | O6-Benzylguanine distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID