For research use only.

Catalog No.S3658 Synonyms: O6-BG

O6-Benzylguanine Chemical Structure

Molecular Weight(MW): 241.25

O6-Benzylguanine (O6-BG) is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.

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Biological Activity

Description O6-Benzylguanine (O6-BG) is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.
AGT [1]
In vitro

Pirenzepine is a antimuscarinic agent which, unlike classic anticholinergic agents, inhibits gastric acid secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular and urinary functions[1].


Solubility (25°C)

In vitro DMSO 48 mg/mL (198.96 mM)
Ethanol 12 mg/mL (49.74 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 241.25


CAS No. 19916-73-5
Storage powder
in solvent
Synonyms O6-BG
Smiles NC1=NC2=C(N=C[NH]2)C(=N1)OCC3=CC=CC=C3

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT00275002 Completed Drug: O6-benzylguanine|Drug: temozolomide Brain and Central Nervous System Tumors National Cancer Institute (NCI) February 2006 Phase 2
NCT00086970 Terminated Drug: ifosfamide|Drug: O6-benzylguanine Unspecified Adult Solid Tumor Protocol Specific National Cancer Institute (NCI) June 2004 Phase 1
NCT00613093 Completed Drug: Temodar and O6-Benzylguanine (BG) Glioblastoma Multiforme|Anaplastic Glioma Duke University|Keryx / AOI Pharmaceuticals Inc.|National Institutes of Health (NIH) October 2002 Phase 2
NCT00005981 Completed Drug: O6-benzylguanine|Drug: carmustine Colorectal Cancer Case Comprehensive Cancer Center|National Cancer Institute (NCI) June 2000 Phase 2
NCT00004072 Completed Drug: O6-benzylguanine|Drug: carmustine Multiple Myeloma and Plasma Cell Neoplasm Case Comprehensive Cancer Center|National Cancer Institute (NCI) September 1999 Phase 2

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Transferase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID