O6-Benzylguanine

Catalog No.S3658 Synonyms: O6-BG

For research use only.

O6-Benzylguanine (O6-BG) is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.

O6-Benzylguanine Chemical Structure

CAS No. 19916-73-5

Selleck's O6-Benzylguanine has been cited by 1 Publication

Purity & Quality Control

Choose Selective DNA alkylator Inhibitors

Biological Activity

Description O6-Benzylguanine (O6-BG) is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.
Targets
AGT [1]
()
In vitro

Pirenzepine is a antimuscarinic agent which, unlike classic anticholinergic agents, inhibits gastric acid secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular and urinary functions[1].

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 48 mg/mL
(198.96 mM)
Water Insoluble
Ethanol ''12 mg/mL

Chemical Information

Molecular Weight 241.25
Formula

C12H11N5O

CAS No. 19916-73-5
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC=C(C=C1)COC2=NC(=NC3=C2NC=N3)N

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT00275002 Completed Drug: O6-benzylguanine|Drug: temozolomide Brain and Central Nervous System Tumors National Cancer Institute (NCI) February 2006 Phase 2
NCT00086970 Terminated Drug: ifosfamide|Drug: O6-benzylguanine Unspecified Adult Solid Tumor Protocol Specific National Cancer Institute (NCI) June 2004 Phase 1
NCT00613093 Completed Drug: Temodar and O6-Benzylguanine (BG) Glioblastoma Multiforme|Anaplastic Glioma Duke University|Keryx / AOI Pharmaceuticals Inc.|National Institutes of Health (NIH) October 2002 Phase 2
NCT00005981 Completed Drug: O6-benzylguanine|Drug: carmustine Colorectal Cancer Case Comprehensive Cancer Center|National Cancer Institute (NCI) June 2000 Phase 2
NCT00004072 Completed Drug: O6-benzylguanine|Drug: carmustine Multiple Myeloma and Plasma Cell Neoplasm Case Comprehensive Cancer Center|National Cancer Institute (NCI) September 1999 Phase 2

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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