Name: Oseltamivir Phosphate
Brand: Selleck Chemicals
SKU: S2597
Rating: 5 (8 reviews)

Oseltamivir Phosphate(Tamiflu) is a potent and selective inhibitor of the neuraminidase that is essential for replication of influenza A and B viruses, used to prevent influenza.

Oseltamivir Phosphate Chemical Structure

CAS: 204255-11-8

Selleck's Oseltamivir Phosphate has been cited by 8 Publications

1 Customer Review

Purity & Quality Control

Batch: Purity: 99.99%

99.99

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Choose Selective Neuraminidase Inhibitors

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
MDCK cells	Function assay		36 h		Antiinfluenza activity against influenza A virus H3N2 infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect after 36 hrs, IC50=1.1 μM	22341943
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Biological Activity

Description

Oseltamivir Phosphate(Tamiflu) is a potent and selective inhibitor of the neuraminidase that is essential for replication of influenza A and B viruses, used to prevent influenza.

Targets

Neuraminidase ^[1]

In vitro
In vitro	Oseltamivir Phosphate, anti-Neu1 antibodies, and matrix metalloproteinase-9-specific inhibitor blocks Neu1 activity associated with EGF-stimulated TNBC MDA-MB-231 cells^[2]. Oseltamivir slows the spread of influenza (flu) virus between cells in the body by stopping the virus from chemically cutting ties with its host cell.
Cell Research	Cell lines	MDA-MB-231 cells/MCF-7 cells
	Concentrations	500, 600, 700, 800 μg/mL
	Incubation Time	24, 48, and 72 h
	Method	Cells are incubated in 96-well plates (5,000 cells/well) and allowed to adhere for 24 hours in 1× DMEM media containing 10% FCS. The media are replaced with fresh DMEM media containing 5% FCS with or without various concentrations of tamoxifen or OP for indicated time periods. Cell viability is tested using WST-1 cell proliferation assay.

In Vivo
In vivo	Oseltamivir Phosphate monotherapy may be the effective treatment therapy for TNBC(Triple-negative breast cancers)^[2]. It is efficacious in treating infections caused by H5N1 and H9N2 influenza viruses in mice^[3]. After dosing, the prodrug (Oseltamivir phosphate) is readily absorbed from the gastrointestinal tract and rapidly converted into the active metabolite, OC. In all patient groups, OC has high bioavailability and is systemically distributed to infection sites at concentrations sufficient to inhibit a range of influenza virus neuraminidases^[4].
Animal Research	Animal Models	RAGxCγ double mutant mouse
	Dosages	30 or 50 mg/kg
	Administration	i.p.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT05375864	Not yet recruiting	Severe Influenza	Assistance Publique - Hôpitaux de Paris	December 1 2022	Not Applicable
NCT02507648	Completed	Healthy	Genuine Research Center Egypt\|Pharmacare PLC Palestine	March 2013	Phase 1
NCT01690637	Terminated	Influenza\|Human Influenza	Centers for Disease Control and Prevention\|Universidad del Valle Guatemala\|Hospital Nacional San Juan de Dios de Santa Ana El Salvador\|Hospital Nacional San Juan de Dios de San Miguel El Salvador\|Hospital Del Nino Panama\|Hospital de Especialidades Pediátricas Omar Torrijos Herrera Panama\|Hospital Jose Domingo de Obaldia Panama	September 2012	Phase 4
NCT01443806	Completed	Metabolic Disease	University of Oxford\|South East Asia Infectious Disease Clinical Research Network	July 2011	Phase 4

References

[4] Davies BE, et al. J Antimicrob Chemother. 2010, 65 Suppl 2:ii5-ii10.

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Chemical Information & Solubility

Molecular Weight	410.4	Formula	C₁₆H₂₈N₂O₄.H₃PO₄
CAS No.	204255-11-8	SDF	Download Oseltamivir Phosphate SDF
Smiles	CCC(CC)OC1C=C(CC(C1NC(=O)C)N)C(=O)OCC.OP(=O)(O)O
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 82 mg/mL ( (199.8 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
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