Oseltamivir Phosphate

Catalog No.S2597

Oseltamivir Phosphate  Chemical Structure

Molecular Weight(MW): 410.4

Oseltamivir Phosphate is a potent and selective inhibitor of the neuraminidase that is essential for replication of influenza A and B viruses, used to prevent influenza.

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Cited by 1 Publication

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  • Nystatin, filipin III, and oseltamivir inhibit the labeling of trophozoites by CTXB and GM1 antibodies. (A) Trophozoites were treated with nystatin (27 μM), filipin III (7.6 μM), and oseltamivir (20 μM) for 30 min before labeling with Alexa Fluor-conjugated CTXB antibody (images a to d) and GM1 antibody (images a′ to d′). Myriocin (27 μM), a sphingolipid inhibitor, was used as a negative control (images e and e′). N, nucleus; PM, plasma membrane; F, flagella; VD, ventral disc. Bars, 5 μm. (B and C) Changes in intensity of control and inhibitor-treated trophozoites. For intensity measurements, cells were randomly selected from 10 to 15 fields from 3 to 5 separate experiments. Approximately 50 cells were considered for each condition and were analyzed using Zeiss Zen 2009 confocal software. One-way ANOVAs were performed to evaluate differences (means ± SDs) between the treatment and control groups. Mean intensities from 3 to 5 separate experiments are shown in panels B and C. Statistical significance was calculated using a one-way ANOVA test, followed by the Tukey (B) and Holm-Šídák (C) methods. *, P < 0.05; **, P < 0.01; ***, P < 0.001; NS, not significant.

    Infect Immun, 2015, 83(5):2030-42. . Oseltamivir Phosphate purchased from Selleck.

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Biological Activity

Description Oseltamivir Phosphate is a potent and selective inhibitor of the neuraminidase that is essential for replication of influenza A and B viruses, used to prevent influenza.
Targets
Neuraminidase [1]
In vitro

Oseltamivir Phosphate, anti-Neu1 antibodies, and matrix metalloproteinase-9-specific inhibitor blocks Neu1 activity associated with EGF-stimulated TNBC MDA-MB-231 cells[2]. Oseltamivir slows the spread of influenza (flu) virus between cells in the body by stopping the virus from chemically cutting ties with its host cell.

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MDCK cells MUXGeY5kfGmxbjDhd5NigQ>? MXqzOkBp NY\XW3pSSW62aXnu[ox2\W68YTDhZ5Rqfmm2eTDh[4FqdnO2IHnu[ox2\W68YTDBJJZqenW|IFizUlIhcW6oZXP0[YQhcW5iTVTDT{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhq[yCnZn\lZ5Qh[W[2ZYKgN|YhcHK|LDDJR|UxRTFwMTFOwG0> NFHuNVgzOjN2MUm0Ny=>

... Click to View More Cell Line Experimental Data

In vivo Oseltamivir Phosphate monotherapy may be the effective treatment therapy for TNBC(Triple-negative breast cancers)[2]. It is efficacious in treating infections caused by H5N1 and H9N2 influenza viruses in mice[3]. After dosing, the prodrug (Oseltamivir phosphate) is readily absorbed from the gastrointestinal tract and rapidly converted into the active metabolite, OC. In all patient groups, OC has high bioavailability and is systemically distributed to infection sites at concentrations sufficient to inhibit a range of influenza virus neuraminidases[4].

Protocol

Cell Research:[2]
+ Expand
  • Cell lines: MDA-MB-231 cells/MCF-7 cells
  • Concentrations: 500, 600, 700, 800 μg/mL
  • Incubation Time: 24, 48, and 72 h 
  • Method: Cells are incubated in 96-well plates (5,000 cells/well) and allowed to adhere for 24 hours in 1× DMEM media containing 10% FCS. The media are replaced with fresh DMEM media containing 5% FCS with or without various concentrations of tamoxifen or OP for indicated time periods. Cell viability is tested using WST-1 cell proliferation assay.
    (Only for Reference)
Animal Research:[2]
+ Expand
  • Animal Models: RAGxCγ double mutant mouse
  • Formulation: saline
  • Dosages: 30 or 50 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 4 mg/mL warmed (9.74 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 410.4
Formula

C16H28N2O4.H3PO4

CAS No. 204255-11-8
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03754686 Not yet recruiting Influenza Rambam Health Care Campus February 10 2019 Phase 4
NCT03754686 Not yet recruiting Influenza Rambam Health Care Campus February 10 2019 Phase 4
NCT03629184 Recruiting Influenza Hoffmann-La Roche November 20 2018 Phase 3
NCT03629184 Recruiting Influenza Hoffmann-La Roche November 20 2018 Phase 3
NCT01965626 Recruiting Thrombocytopenia Shandong University|The Affiliated Hospital of the Chinese Academy of Military Medical Sciences|Anhui Medical University|The First Affiliated Hospital of Dalian Medical University|Shenzhen Second People''s Hospital|Zhejiang Provincial Hospital of TCM September 1 2018 Phase 2
NCT01965626 Recruiting Thrombocytopenia Shandong University|The Affiliated Hospital of the Chinese Academy of Military Medical Sciences|Anhui Medical University|The First Affiliated Hospital of Dalian Medical University|Shenzhen Second People''s Hospital|Zhejiang Provincial Hospital of TCM September 1 2018 Phase 2

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID