Olopatadine HCl

Catalog No.S2494

For research use only.

Olopatadine HCl is a histamine blocker and mast cell stabilizer with an IC50 of 559 μM for the release of histamine.

Olopatadine HCl  Chemical Structure

CAS No. 140462-76-6

Purity & Quality Control

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Biological Activity

Description Olopatadine HCl is a histamine blocker and mast cell stabilizer with an IC50 of 559 μM for the release of histamine.
Targets
Histamine receptor [1]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 75 mg/mL
(200.6 mM)
Water 13 mg/mL
(34.77 mM)
Ethanol 8 mg/mL
(21.39 mM)

Chemical Information

Molecular Weight 373.87
Formula

C21H23NO3.HCl

CAS No. 140462-76-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CN(C)CCC=C1C2=CC=CC=C2COC3=C1C=C(C=C3)CC(=O)O.Cl

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01287338 Terminated Drug: Olopatadine Seasonal Allergic Conjunctivitis to Ragweed Mati Therapeutics Inc. October 2010 Phase 2
NCT00775658 Completed Drug: olopatadine|Drug: placebo Allergic Rhinitis|Allergic Conjunctivitis Vanderbilt University Medical Center January 2008 Not Applicable
NCT00609128 Completed Drug: olopatadine Allergic Conjunctivitis University of Wisconsin Madison|National Eye Institute (NEI) September 2000 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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