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Olopatadine HCl Histamine Receptor inhibitor

Cat.No.S2494

Olopatadine HCl(ALO4943A,KW4679) is a histamine blocker and mast cell stabilizer with an IC50 of 559 μM for the release of histamine.
Olopatadine HCl Histamine Receptor inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 373.87

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Quality Control

Batch: S249401 DMSO]75 mg/mL]false]Water]13 mg/mL]false]Ethanol]8 mg/mL]false Purity: 99.97%
99.97

Solubility

In vitro
Batch:

DMSO : 75 mg/mL (200.6 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 13 mg/mL

Ethanol : 8 mg/mL

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In vivo
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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Chemical Information, Storage & Stability

Molecular Weight 373.87 Formula

C21H23NO3.HCl

 Storage (From the date of receipt)
CAS No. 140462-76-6 Download SDF Storage of Stock Solutions

Synonyms ALO4943A,KW4679 Smiles CN(C)CCC=C1C2=CC=CC=C2COC3=C1C=C(C=C3)CC(=O)O.Cl

Mechanism of Action

Targets/IC50/Ki
Histamine receptor

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01287338 Terminated
Seasonal Allergic Conjunctivitis to Ragweed
Mati Therapeutics Inc.
 October 2010 Phase 2
NCT00775658 Completed
Allergic Rhinitis|Allergic Conjunctivitis
Vanderbilt University Medical Center
 January 2008 Not Applicable
NCT00609128 Completed
Allergic Conjunctivitis
University of Wisconsin Madison|National Eye Institute (NEI)
 September 2000 Not Applicable

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