Oxolinic acid

Catalog No.S4537 Synonyms: Urinox, NSC 110364

Oxolinic acid Chemical Structure

Molecular Weight(MW): 261.23

Oxolinic acid is a quinolone antibiotic, inhibiting the enzyme DNA gyrase and DNA synthesis.It also acts as a dopamine reuptake inhibitor.

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Biological Activity

Description Oxolinic acid is a quinolone antibiotic, inhibiting the enzyme DNA gyrase and DNA synthesis.It also acts as a dopamine reuptake inhibitor.
Targets
bacterial DNA gyrase [3] DNA synthesis [4] dopamine uptake [2]
4.3 μM
In vitro

Oxolinic acid, a quinolone antibacterial agent, inhibits reversibly the ATP-dependent replicative DNA synthesis in permeable cell systems as well as in cellophane disk lysates[4]. It also inhibits bacterial DNA gyrase but not eukaryotic topoisomerases, reversibly binding gyrase subunit A in gyrase-DNA complexes, blocking supercoiling activity and inhibiting DNA synthesis at 0.5-5 µg/ml[5][6][7].

In vivo The antimicrobial agent oxolinic acid, injected i.p. in mice, induces a dose dependent increase in locomotor activity. the stimulant locomotor effect of oxolinic acid depends on the blockade of the neuronal dopamine uptake complex[2].

Protocol

Animal Research:

[1]

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  • Animal Models: Mice(ICR mice), rats( Sprague-Dawley rats), and beagle dogs
  • Formulation: 0.5% aqueous carboxymethylcellulose solution
  • Dosages: 20, 50, and 100 mg/kg
  • Administration: By gavage
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 0.5 mg/mL warmed (1.91 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 261.23
Formula

C13H11NO5

CAS No. 14698-29-4
Storage powder
in solvent
Synonyms Urinox, NSC 110364

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID