Catalog No.S4537 Synonyms: Urinox, NSC 110364
Molecular Weight(MW): 261.23
Oxolinic acid is a quinolone antibiotic, inhibiting the enzyme DNA gyrase and DNA synthesis.It also acts as a dopamine reuptake inhibitor.
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|Description||Oxolinic acid is a quinolone antibiotic, inhibiting the enzyme DNA gyrase and DNA synthesis.It also acts as a dopamine reuptake inhibitor.|
Oxolinic acid, a quinolone antibacterial agent, inhibits reversibly the ATP-dependent replicative DNA synthesis in permeable cell systems as well as in cellophane disk lysates. It also inhibits bacterial DNA gyrase but not eukaryotic topoisomerases, reversibly binding gyrase subunit A in gyrase-DNA complexes, blocking supercoiling activity and inhibiting DNA synthesis at 0.5-5 µg/ml.
|In vivo||The antimicrobial agent oxolinic acid, injected i.p. in mice, induces a dose dependent increase in locomotor activity. the stimulant locomotor effect of oxolinic acid depends on the blockade of the neuronal dopamine uptake complex.|
-  Izawa A, et al. Antimicrob Agents Chemother. 1980, 18(1):41-44.
-  Garcia de Mateos-Verchere J, et al. Eur Neuropsychopharmacol. 1998, 8(4):255-259.
-  O'Connor MB, et al. J Mol Biol. 1985, 181(4):545-550.
|In vitro||DMSO||0.5 mg/mL warmed (1.91 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Synonyms||Urinox, NSC 110364|
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