Home DNA Damage/DNA Repair DNA/RNA Synthesis inhibitor Oxolinic acid For research use only.

Oxolinic acid

Synonyms: Urinox, NSC 110364

Oxolinic acid (Urinox, NSC 110364) is a quinolone antibiotic, inhibiting the enzyme DNA gyrase and DNA synthesis.It also acts as a dopamine reuptake inhibitor.

Oxolinic acid Chemical Structure

Oxolinic acid Chemical Structure

CAS: 14698-29-4

Purity & Quality Control

Batch: S453701 0.5MNAOH] 6.02 mg/mL] false] DMSO] 0.5 mg/mL] false] Water] Insoluble] false Purity: 99.39%
99.39

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Biological Activity

Description Oxolinic acid (Urinox, NSC 110364) is a quinolone antibiotic, inhibiting the enzyme DNA gyrase and DNA synthesis.It also acts as a dopamine reuptake inhibitor.
Targets
bacterial DNA gyrase [3] DNA synthesis [4] dopamine uptake [2]
4.3 μM
In vitro
In vitro Oxolinic acid, a quinolone antibacterial agent, inhibits reversibly the ATP-dependent replicative DNA synthesis in permeable cell systems as well as in cellophane disk lysates[4]. It also inhibits bacterial DNA gyrase but not eukaryotic topoisomerases, reversibly binding gyrase subunit A in gyrase-DNA complexes, blocking supercoiling activity and inhibiting DNA synthesis at 0.5-5 µg/ml[5][6][7].
In Vivo
In vivo The antimicrobial agent oxolinic acid, injected i.p. in mice, induces a dose dependent increase in locomotor activity. the stimulant locomotor effect of oxolinic acid depends on the blockade of the neuronal dopamine uptake complex[2].
Animal Research Animal Models Mice(ICR mice), rats( Sprague-Dawley rats), and beagle dogs
Dosages 20, 50, and 100 mg/kg
Administration By gavage

Chemical Information & Solubility

Molecular Weight 261.23 Formula

C13H11NO5
CAS No. 14698-29-4 SDF Download Oxolinic acid SDF
Smiles CCN1C=C(C(=O)C2=CC3=C(C=C21)OCO3)C(=O)O
Storage (From the date of receipt)

In vitro
Batch:

0.5MNAOH : 6.02 mg/mL

DMSO : 0.5 mg/mL ( (1.91 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble


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In vivo
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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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