OSS_128167

For research use only.

Catalog No.S8627 Synonyms: SIRT6-IN-1

10 publications

OSS_128167 Chemical Structure

CAS No. 887686-02-4

OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor with IC50 values of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-viral effect in HBV transcription and replication.

Selleck's OSS_128167 has been cited by 10 publications

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Biological Activity

Description OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor with IC50 values of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-viral effect in HBV transcription and replication.
Targets
SIRT6 [1]
(Cell-free)
SIRT2 [1]
(Cell-free)
SIRT1 [1]
(Cell-free)
89 μM 751 μM 1578 μM
In vitro

OSS-128167 is a selective compounds toward SIRT6 with IC50 values toward SIRT1 and SIRT2 being approximately 20 times higher. It is cell permeable and active in cultured cells. OSS-128167 increases H3K9 acetylation and GLUT-1 expression[1].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
BxPC3 NWjtW5N3TnWwY4Tpc44h[XO|YYm= NHO1OXkyODBidV2= M1\aUlE5KGi{cx?= M3zCdWlvcGmkaYTpc44hd2ZiU1nSWFYhcW5iaIXtZY4hSniSQ{OgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hUDONOTDhZ4V1gWyjdHnvckBifCBzMECgeW0h[W[2ZYKgNVghcHK|IHL5JIludXWwb3Lsc5Qh[W6jbInzbZM> M{\OcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2N{i1O|A2Lz5{NEe4OVcxPTxxYU6=
BxPC3 NGrQO2xHfW6ldHnvckBie3OjeR?= NXTBPGE{OTJwNTD0c{AzODBidV2= M1nqc|I1KGi{cx?= NH:4cnhKdmO{ZXHz[UBqdiCJTGXUNUBmgHC{ZYPzbY9vKGmwIHj1cYFvKEK6UFOzJINmdGy|IHH0JFEzNjVidH:gNlAxKHWPIHHmeIVzKDJ2IHjyd{BjgSCZZYP0[ZJvKGKub4T0bY5oKGGwYXz5d4l{ NXrTRlhqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS3PFU4ODVpPkK0O|g2PzB3PD;hQi=>

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Protocol

Cell Research:

[1]

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  • Cell lines: BxPC3 cells
  • Concentrations: 100 μM
  • Incubation Time: 0, 2, 6, 18, 24 h
  • Method:

    4 × 105 BxPC3 cells are plated in six-well plates and allowed to adhere for 24 h. Thereafter, cells are stimulated with 100 μM OSS-128167 or the respective amounts of vehicle DMSO for the indicated time amounts. Finally, cells are used for protein lysate generation, and total H3 and acetylated H3K9 levels are detected by immunoblotting.


    (Only for Reference)

Solubility (25°C)

In vitro DMSO 73 mg/mL (199.27 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+40% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.
12mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 366.32
Formula

C19H14N2O6

CAS No. 887686-02-4
Storage powder
in solvent
Synonyms SIRT6-IN-1
Smiles C1=CC(=CC(=C1)NC(=O)C2=CC=CO2)C(=O)NC3=CC(=C(C=C3)O)C(=O)O

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID