Catalog No.S7217 Synonyms: BAS 00287861

OAC1 Chemical Structure

Molecular Weight(MW): 237.26

OAC1 (Oct4-activating compound 1) can enhance the efficiency of reprogramming.

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Biological Activity

Description OAC1 (Oct4-activating compound 1) can enhance the efficiency of reprogramming.
Oct4 [1]
In vitro

OAC1 at 1 μM enhances reprogramming efficiency by activating both Oct4 and Nanog promoter-driven luciferase reporter genes. Furthermore, OAC1 enhances the pluripotent stem cells (iPSC) reprogramming efficiency and accelerates the reprogramming process in the quartet reprogramming factors (Oct4, Sox2, c-Myc, and Klf4) treated mouse embryonic fibroblasts (MEFs). The iPSC colonies derived using OAC1 along with the quartet factors exhibits typical ESC morphology, gene-expression pattern, and developmental potential. OAC1 seems to enhance reprogramming efficiency via increasing transcription of the Oct4-Nanog-Sox2 triad and Tet1, a gene known to be involved in DNA demethylation. While it doesn’t inhibit the p53-p21 pathway or activate the Wnt-β-catenin signaling. OAC1 may be used to enhance the reprogramming of somatic cells to a pluripotent state. [1]


Cell Research:[1]
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  • Cell lines: Human ESCs transfected with human Oct4 and Nanog luciferase reporter genes
  • Concentrations: ~1 μM
  • Incubation Time: 24 h
  • Method: The Oct4-luc or Nanog-luc cells are treated with compound OAC1 at 1 μM concentration. Luciferase reporter assays are performed 24 h after OAC1 treatment.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 47 mg/mL (198.09 mM)
Ethanol 21 mg/mL (88.51 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 237.26


CAS No. 300586-90-7
Storage powder
in solvent
Synonyms BAS 00287861

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID