Oxytetracycline (Terramycin)

Catalog No.S1773

For research use only.

Oxytetracycline is a broad-spectrum tetracycline antibiotic, used to treat infections with bacteria.

Oxytetracycline (Terramycin) Chemical Structure

CAS No. 79-57-2

Selleck's Oxytetracycline (Terramycin) has been cited by 2 Publications

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Biological Activity

Description Oxytetracycline is a broad-spectrum tetracycline antibiotic, used to treat infections with bacteria.
In vivo Oxytetracycline (200 mg/kg for 15 days) results a significant elevation in serum hepatospecific markers such as aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase, and bilirubin and the levels of lipid peroxidation markers (thiobarbituric acid reactive substances (TBARS) and lipid hydroperoxides) in rat liver. Oxytetracycline also causes a significant reduction in the activities of superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione (GSH), vitamin C and vitamin E in rat liver. Oxytetracycline (200 mg/kg) combined with Naringenin (50 mg/kg b.w.t.) significantly decreases the activities of serum aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase and the levels of bilirubin along with significant decrease in the levels of lipid peroxidation markers in the rat liver. [1] Oxytetracycline (200 mg/kg, oral for 15 days) produces hepatic damage as manifested by a significant increase in serum hepatic markers namely aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), bilirubin and increases plasma and hepatic lipid peroxidation indices (TBARS and hydroperoxide) in rats. Oxytetracycline significantly decreases the levels of enzymatic antioxidants namely superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). [2]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 460.43


CAS No. 79-57-2
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1(C2C(C3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O)O

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01032499 Unknown status Drug: oxytetracycline taro elixir|Drug: Taro Elixir Acne Vulgaris II or III Degree|Boils Laboratorios Goulart S.A. May 2010 Phase 3

(data from https://clinicaltrials.gov, updated on 2022-08-01)

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