Home DNA Damage/DNA Repair Topoisomerase inhibitor Ofloxacin

research use only

Ofloxacin Topoisomerase inhibitor

Cat.No.S1463

Ofloxacin (DL8280) is a synthetic broad-spectrum antimicrobial agent.
Ofloxacin Topoisomerase inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 361.37

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Chemical Information, Storage & Stability

Molecular Weight 361.37 Formula

C18H20FN3O4

 Storage (From the date of receipt)
CAS No. 82419-36-1 Download SDF Storage of Stock Solutions

Synonyms DL8280 Smiles CC1COC2=C3N1C=C(C(=O)C3=CC(=C2N4CCN(CC4)C)F)C(=O)O

Solubility

In vitro
Batch:

DMSO : 0.4 mg/mL ( (1.1 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC50/Ki
Topo II [1]
Topoisomerase IV [1]

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05743101 Not yet recruiting
Acute Ischemic Stroke
Yi Yang|The First Hospital of Jilin University
 April 1 2024 Not Applicable
NCT05799326 Recruiting
Acute Ischemic Stroke
Yi Yang|The First Hospital of Jilin University
 June 30 2023 Not Applicable
NCT05741905 Recruiting
Acute Ischemic Stroke
Yi Yang|The First Hospital of Jilin University
 June 1 2023 Not Applicable
NCT05441930 Withdrawn
Cataract
PolyActiva Pty Ltd
 June 23 2023 Phase 1

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.

Signaling Pathway Map