Catalog No.S4691 Synonyms: Eusolex 4360, Escalol 567, KAHSCREEN BZ-3, Benzophenone 3

For research use only.

Oxybenzone is a benzophenone derivative used as a sunscreen agent.

Oxybenzone Chemical Structure

CAS No. 131-57-7

Selleck's Oxybenzone has been cited by 1 Publication

Purity & Quality Control

Related Other Products

Biological Activity

Description Oxybenzone is a benzophenone derivative used as a sunscreen agent.
In vitro

A dose-dependent inhibition of PGE2-production is found in the HEPM cell culture following oxybenzone exposure[1]. Benzophenones, including oxybenzone(BP-3) are documented mutagens that increase the rate of damage to DNA, especially when exposed to sunlight. It either can act directly as genotoxicants or become genotoxicants by bioactivation via cytochrome P450 enzymes. Oxybenzone can generate reactive oxygen species, which are potential mutagens, when applied topically to the skin followed by UV light exposure[2].

In vivo In mice studies, oxybenzone(BP-3) exposure significantly affects fecundity, as well as inducing unexplained mortality in lactating mothers. Studies in both mice and rats demonstrate that generational exposure to oxybenzone(BP-3) reduces body weight, increases liver ([50 %) and kidney weights, induces a 30 % increase in prostate weight, a reduction in immunocompetence, and significantly increases uterine weight in juveniles. In mammals, oxybenzone(BP-3) is renowned for having estrogenic and anti-androgenic activities, causing activation of estrogen receptor proteins and inhibition of androgen receptors[2].

Protocol (from reference)

Cell Research:


  • Cell lines: Human embryo palatal mesenchyme cells
  • Concentrations: 0.01-50 μM
  • Incubation Time: 24 h
  • Method:

    Cells are grown at 37℃ with 100% humidity and 10% CO2. Prior to analyses, cells are subcultured onto 24-well plates and allowed to become 70-90% confluent. On day 1 of the experiment, cells are washed three times with serum-free media containing 0.5% bovine serum albumin (BSA), followed by replacement with the same media that also contained 1 ng/ml of IL-1β with or without oxybenzone. After an exposure time of 24 h, the media are removed, the pH adjusted to 3.5 with HCl, and finally assayed for PGE2-production.

Solubility (25°C)

In vitro

DMSO 45 mg/mL
(197.16 mM)
Ethanol 45 mg/mL
(197.16 mM)
Water Insoluble

Chemical Information

Molecular Weight 228.24


CAS No. 131-57-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles COC1=CC(=C(C=C1)C(=O)C2=CC=CC=C2)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Oxybenzone | Oxybenzone ic50 | Oxybenzone price | Oxybenzone cost | Oxybenzone solubility dmso | Oxybenzone purchase | Oxybenzone manufacturer | Oxybenzone research buy | Oxybenzone order | Oxybenzone mouse | Oxybenzone chemical structure | Oxybenzone mw | Oxybenzone molecular weight | Oxybenzone datasheet | Oxybenzone supplier | Oxybenzone in vitro | Oxybenzone cell line | Oxybenzone concentration | Oxybenzone nmr