Oxybenzone

Catalog No.S4691 Synonyms: Eusolex 4360, Escalol 567, KAHSCREEN BZ-3, Benzophenone 3

For research use only.

Oxybenzone is a benzophenone derivative used as a sunscreen agent.

Oxybenzone Chemical Structure

CAS No. 131-57-7

Selleck's Oxybenzone has been cited by 1 Publication

Purity & Quality Control

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Biological Activity

Description Oxybenzone is a benzophenone derivative used as a sunscreen agent.
In vitro

A dose-dependent inhibition of PGE2-production is found in the HEPM cell culture following oxybenzone exposure[1]. Benzophenones, including oxybenzone(BP-3) are documented mutagens that increase the rate of damage to DNA, especially when exposed to sunlight. It either can act directly as genotoxicants or become genotoxicants by bioactivation via cytochrome P450 enzymes. Oxybenzone can generate reactive oxygen species, which are potential mutagens, when applied topically to the skin followed by UV light exposure[2].

In vivo In mice studies, oxybenzone(BP-3) exposure significantly affects fecundity, as well as inducing unexplained mortality in lactating mothers. Studies in both mice and rats demonstrate that generational exposure to oxybenzone(BP-3) reduces body weight, increases liver ([50 %) and kidney weights, induces a 30 % increase in prostate weight, a reduction in immunocompetence, and significantly increases uterine weight in juveniles. In mammals, oxybenzone(BP-3) is renowned for having estrogenic and anti-androgenic activities, causing activation of estrogen receptor proteins and inhibition of androgen receptors[2].

Protocol (from reference)

Cell Research:

[1]

  • Cell lines: Human embryo palatal mesenchyme cells
  • Concentrations: 0.01-50 μM
  • Incubation Time: 24 h
  • Method:

    Cells are grown at 37℃ with 100% humidity and 10% CO2. Prior to analyses, cells are subcultured onto 24-well plates and allowed to become 70-90% confluent. On day 1 of the experiment, cells are washed three times with serum-free media containing 0.5% bovine serum albumin (BSA), followed by replacement with the same media that also contained 1 ng/ml of IL-1β with or without oxybenzone. After an exposure time of 24 h, the media are removed, the pH adjusted to 3.5 with HCl, and finally assayed for PGE2-production.

Solubility (25°C)

In vitro

DMSO 45 mg/mL
(197.16 mM)
Ethanol 45 mg/mL
(197.16 mM)
Water Insoluble

Chemical Information

Molecular Weight 228.24
Formula

C14H12O3

CAS No. 131-57-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles COC1=CC(=C(C=C1)C(=O)C2=CC=CC=C2)O

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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