Oxacillin sodium monohydrate

Catalog No.S2563 Synonyms: Methicillin

For research use only.

Oxacillin sodium monohydrate (Methicillin) is an antibacterial agent and is a narrow spectrum beta-lactam antibiotic of the penicillin class.

Oxacillin sodium monohydrate Chemical Structure

CAS No. 7240-38-2

Purity & Quality Control

Choose Selective Bacterial Inhibitors

Biological Activity

Description Oxacillin sodium monohydrate (Methicillin) is an antibacterial agent and is a narrow spectrum beta-lactam antibiotic of the penicillin class.

Protocol (from reference)

Solubility (25°C)

In vitro

Water 88 mg/mL
(199.35 mM)
DMSO Insoluble
Ethanol Insoluble

Chemical Information

Molecular Weight 441.43


CAS No. 7240-38-2
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=C(C(=NO1)C2=CC=CC=C2)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)[O-].O.[Na+]

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05100407 Not yet recruiting -- Multi-antibiotic Resistance Kufa University October 2021 --
NCT04597424 Recruiting Drug: Experimental: doxycycline|Biological: Bexsero® vaccine Unsafe Sex|Risk-Taking ANRS Emerging Infectious Diseases January 19 2021 Phase 3
NCT04160468 Recruiting Drug: Exebacase|Drug: Placebo Staphylococcus Aureus Bacteremia|Staphylococcus Aureus Endocarditis ContraFect December 20 2019 Phase 3
NCT03643952 Completed Drug: Daptomycin for Injection Bacteremia|Soft Tissue Infections|Skin Diseases Infectious Merck Sharp & Dohme Corp. December 6 2018 Phase 2

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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