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Olodaterol Adrenergic Receptor agonist

Name: Olodaterol
Brand: Selleck Chemicals
SKU: S4485
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S4485

Olodaterol is a long-acting β2-adrenergic receptor agonist that is used as a component of an inhalation (Tiotropium/this compound) for treating patients with chronic obstructive pulmonary disease (COPD).

Chemical Structure

Molecular Weight: 386.44

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Quality Control

Batch: S448501 DMSO]77 mg/mL]false]Ethanol]40 mg/mL]false]Water]Insoluble]false Purity: 99.44%

Cited in Nature Medicine for its top-tier quality
COA
NMR
HPLC
SDS
Datasheet

99.44

Related Targets	Estrogen/progestogen Receptor GPR Androgen Receptor Glucocorticoid Receptor ACE RAAS Progesterone Receptor Opioid Receptor PGES THR
Other Adrenergic Receptor Inhibitors	Zenidolol (ICI-118551) Hydrochloride Yohimbine HCl L755507 Atipamezole Higenamine hydrochloride Fenoterol hydrobromide Medetomidine HCl Rauwolscine hydrochloride Deoxycorticosterone acetate Detomidine HCl

Solubility

In vitro
Batch:

DMSO : 77 mg/mL (199.25 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 40 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	3.850mg/ml (9.96mM)	Taking the 1 mL working solution as an example, add 50 μL of 77 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.550mg/ml (1.42mM)	Taking the 1 mL working solution as an example, add 50 μL of 11 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	386.44	Formula	C₂₁H₂₆N₂O₅	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	868049-49-4	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	BI 1744			Smiles	COC1=CC=C(CC(C)(C)NCC(O)C2=C3OCC(=O)NC3=CC(=C2)O)C=C1

Mechanism of Action

Targets/IC₅₀/Ki	β2-adrenergic receptor
In vivo	The bronchoprotective half-life of abediterol in guinea pigs is 47 h for olodaterol. In anaesthetised dogs, this compound inhibits acetylcholine-induced bronchoconstriction, with ID40 (dose inhibiting bronchoconstriction by 40%) of 0.180 µg/kg. In parallel, effect on heart rate in dogs is measured, showing a safety index (defined as the ratio of the maximal dose without effect on heart rate and the ID40) of 10.5.
References	[1] https://pubmed.ncbi.nlm.nih.gov/31119643/ [2] https://pubmed.ncbi.nlm.nih.gov/26656755/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT03030638	Completed	Pulmonary Disease Chronic Obstructive	Boehringer Ingelheim\|RTI health solutions US	February 8 2017	--
NCT02969317	Completed	Pulmonary Disease Chronic Obstructive	Boehringer Ingelheim	February 24 2017	Phase 1
NCT02172118	Completed	Healthy	Boehringer Ingelheim	August 2009	Phase 1

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