Octenidine Dihydrochloride

Catalog No.S5012

For research use only.

Octenidine, a cationic surfactant, is active against gram-positive and gram-negative bacteria.

Octenidine Dihydrochloride Chemical Structure

CAS No. 70775-75-6

Purity & Quality Control

Choose Selective Bacterial Inhibitors

Biological Activity

Description Octenidine, a cationic surfactant, is active against gram-positive and gram-negative bacteria.
In vitro

Octenidine binds to negatively charged surfaces like bacterial cell envelopes and eukaryotic cell membranes probably inducing membrane disruption. Its main binding partners are salts of fatty acids glycerol phosphates, found in the cell membranes of mammalian and bacterial cells. Due to this strong and unspecific interaction with bacterial walls it has a broad antimicrobial spectrum against a variety of Gram-positive and Gram-negative bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), skin microflora and fungi[1].

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 60 mg/mL
(96.18 mM)
Ethanol '-1 mg/mL

Chemical Information

Molecular Weight 623.83
Formula

C36H62N4.2HCl

CAS No. 70775-75-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles Cl.Cl.CCCCCCCCN=C1C=CN(CCCCCCCCCCN2C=CC(C=C2)=NCCCCCCCC)C=C1

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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