Oxybutynin hydrochloride

Catalog No.S3117

For research use only.

Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties.

Oxybutynin hydrochloride Chemical Structure

CAS No. 1508-65-2

Selleck's Oxybutynin hydrochloride has been cited by 1 Publication

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Biological Activity

Description Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties.
Targets
mAChR [1]
In vitro

Oxybutynin relieves urinary and bladder difficulties, including frequent urination and inability to control urination (urge incontinence), by decreasing muscle spasms of the bladder. Oxybutynin competitively antagonizes the M1, M2, and M3 subtypes of the muscarinic acetylcholine receptor. [1] Oxybutynin also has direct spasmolytic effects on bladder smooth muscle as a calcium antagonist and local anesthetic, but at concentrations far above those used clinically. [2]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 79 mg/mL
(200.53 mM)
Ethanol 79 mg/mL
(200.53 mM)
Water 4 mg/mL
(10.15 mM)

Chemical Information

Molecular Weight 393.95
Formula

C22H31NO3.HCl

CAS No. 1508-65-2
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCN(CC)CC#CCOC(=O)C(C1CCCCC1)(C2=CC=CC=C2)O.Cl

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04526353 Not yet recruiting Drug: Oxybutynin 1 mg/ml Syrup Male Urogenital Diseases University Hospital Bordeaux September 10 2020 Phase 2
NCT02522936 Withdrawn Drug: Biotene oral spray Overactive Bladder|Xerostomia|Compliance University of Southern California August 1 2018 Phase 4
NCT02099695 Withdrawn Drug: Oxybutynin|Drug: Placebo Hyperhidrosis Cristália Produtos Químicos Farmacêuticos Ltda.|Hospital Israelita Albert Einstein|University of Sao Paulo December 2015 Phase 3
NCT02327936 Completed Drug: Fesoterodine|Drug: Oxybutynin XL Overactive Bladder Stéphane Bolduc|Pfizer|CHU de Quebec-Universite Laval December 2014 Phase 3

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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