Home Proteases MMP inhibitor o-Phenanthroline For research use only.

o-Phenanthroline

Synonyms: 1,10-Phenanthroline, phen

o-Phenanthroline (1,10-Phenanthroline, phen), a hypoxia-mimicking agent, is a non-specific matrix metalloproteinase (MMP) inhibitor with IC50 of 110.5μM for Collagenase. O-phenanthroline reduces the expression of MMP3 and MMP13 mRNA levels during chondrogenic differentiation of human chondrocytes (hChs), as well as after TNFα/IL-1β exposure in an explant model. o-Phenanthroline is also a metal chelator which prevents the induction of chromosomal aberrations in streptozotocin-treated cells and forms a red chelate with Fe2+ that absorbs maximally at 510 nm.

o-Phenanthroline Chemical Structure

o-Phenanthroline Chemical Structure

CAS: 66-71-7

Selleck's o-Phenanthroline has been cited by 1 publication

Purity & Quality Control

Batch: S683001 DMSO] 36 mg/mL] false] Ethanol] 36 mg/mL] false] Water] Insoluble] false Purity: 99.81%
99.81

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Signaling Pathway

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Biological Activity

Description o-Phenanthroline (1,10-Phenanthroline, phen), a hypoxia-mimicking agent, is a non-specific matrix metalloproteinase (MMP) inhibitor with IC50 of 110.5μM for Collagenase. O-phenanthroline reduces the expression of MMP3 and MMP13 mRNA levels during chondrogenic differentiation of human chondrocytes (hChs), as well as after TNFα/IL-1β exposure in an explant model. o-Phenanthroline is also a metal chelator which prevents the induction of chromosomal aberrations in streptozotocin-treated cells and forms a red chelate with Fe2+ that absorbs maximally at 510 nm.
Targets
MMP-3 [1] MMP-13 [1] Fe2+ [2] Collagenase [1]
(Cell-free assay)
110.5 μM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05590715 Recruiting
Autism Spectrum Disorder
Stalicla SA
 October 13 2022 --
NCT03049904 Completed
HIV|Substance Use
University of Washington|National Institute on Drug Abuse (NIDA)
 February 19 2017 Not Applicable
NCT02400554 Completed
Obesity|Substance Abuse
University of Washington|National Institute on Drug Abuse (NIDA)
 March 2015 Not Applicable

Chemical Information & Solubility

Molecular Weight 180.21 Formula

C12H8N2
CAS No. 66-71-7 SDF --
Smiles C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 36 mg/mL ( (199.76 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 36 mg/mL

Water : Insoluble


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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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