o-Phenanthroline

For research use only.

Catalog No.S6830 Synonyms: 1,10-Phenanthroline, phen

1 publication

o-Phenanthroline Chemical Structure

CAS No. 66-71-7

o-Phenanthroline (1,10-Phenanthroline, phen), a hypoxia-mimicking agent, is a non-specific matrix metalloproteinase (MMP) inhibitor with IC50 of 110.5μM for Collagenase. O-phenanthroline reduces the expression of MMP3 and MMP13 mRNA levels during chondrogenic differentiation of human chondrocytes (hChs), as well as after TNFα/IL-1β exposure in an explant model. o-Phenanthroline is also a metal chelator which prevents the induction of chromosomal aberrations in streptozotocin-treated cells and forms a red chelate with Fe2+ that absorbs maximally at 510 nm.

Selleck's o-Phenanthroline has been cited by 1 publication

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Biological Activity

Description o-Phenanthroline (1,10-Phenanthroline, phen), a hypoxia-mimicking agent, is a non-specific matrix metalloproteinase (MMP) inhibitor with IC50 of 110.5μM for Collagenase. O-phenanthroline reduces the expression of MMP3 and MMP13 mRNA levels during chondrogenic differentiation of human chondrocytes (hChs), as well as after TNFα/IL-1β exposure in an explant model. o-Phenanthroline is also a metal chelator which prevents the induction of chromosomal aberrations in streptozotocin-treated cells and forms a red chelate with Fe2+ that absorbs maximally at 510 nm.
Targets
MMP-3 [1]
()
MMP-13 [1]
()
Fe2+ [2]
()
Collagenase [1]
(Cell-free assay)
110.5 μM

Protocol

Solubility (25°C)

In vitro DMSO 36 mg/mL (199.76 mM)
Ethanol 36 mg/mL (199.76 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 180.21
Formula

C12H8N2

CAS No. 66-71-7
Storage powder
in solvent
Synonyms 1,10-Phenanthroline, phen
Smiles C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03049904 Completed Behavioral: Vr2L 2Spirit HIV|Substance Use University of Washington|National Institute on Drug Abuse (NIDA) February 19 2017 Not Applicable
NCT02400554 Recruiting Behavioral: Yappalli Obesity|Substance Abuse University of Washington|National Institute on Drug Abuse (NIDA) March 2015 Not Applicable

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID