Osimertinib mesylate

For research use only.

Catalog No.S5078 Synonyms: AZD9291 mesylate

69 publications

Osimertinib mesylate Chemical Structure

CAS No. 1421373-66-1

Osimertinib mesylate (AZD9291) is the mesylate form of osimertinib, which is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug.

Selleck's Osimertinib mesylate has been cited by 69 publications

Purity & Quality Control

Choose Selective EGFR Inhibitors

Biological Activity

Description Osimertinib mesylate (AZD9291) is the mesylate form of osimertinib, which is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug.
Targets
EGFR [1]
()
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
PC9 M4fL[WN6fG:2b4jpZ4l1gSCjc4PhfS=> M4nES|czKGi{cx?= NG\Oe4ZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBRSzliY3XscJMhcGG{Yn;ybY5oKEWJRmKg[ZhwdiBzOTDk[YxmfGmxbjDhZ5RqfmG2aX7nJI12fGGwdDDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgV3lVV1hiZ4Ll[Y4hdnWlbHXpZ{Bi[2mmIIP0ZYlvcW6pLXLhd4VlKG[udX;y[ZNk\W6lZTDhd5NigSxiR1m1NF0xNjB{M988US=> NVHsVoJDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyO|E6PjNpPkK1NlcyQTZ|PD;hQi=>
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NCI-H1975 NFHC[IJHfW6ldHnvckBie3OjeR?= MUWxJJRwKDFyMECgcm0> NWfPWYxjOiCqcoO= NWXifWt4UW6qaXLpeIlwdiCxZjDFS2YucW6mdXPl[EBGT0[UIHvpcoF{\SCmb33hbY4hVDh3OGKvWFc6OE1ibYX0ZY51KHCqb4PwbI9zgWyjdHnvckBqdiCqdX3hckBPS0lvSEG5O|Uh[2WubIOgZZQhOSC2bzCxNFAxKG6PIIDy[U1qdmO3YnH0[YQh\m:{IEKgbJJ{KG[xbHzve4VlKGK7IIP0bY12dGG2aX;uJJdqfGhiRVfGJIZweiBzNTDtbY5{KGK7IGfld5Rmem5iYnzveEBu\XSqb3S= NGe3XJQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{O5OlYyOCd-MkezPVY3OTB:L3G+
NCI-H1975 MWnGeY5kfGmxbjDhd5NigQ>? M1jjXVEhfG9iMUCwNEBvVQ>? MoLDNkBpenN? MYPJcohq[mm2aX;uJI9nKEWJRj3pcoR2[2WmIFXHSnIhc2mwYYPlJIRwdWGrbjDMPFU5Wi:WN{mwUUBufXSjboSgbY4hcHWvYX6gUmNKNUhzOUe1JINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiCHUlugdIhwe3Cqb4L5cIF1cW:wIHH0JFEhfG9iMUCwNEBvVSCycnWtbY5kfWKjdHXkJIZweiB{IHjyd{Bnd2yub4fl[EBjgSC|dHnteYxifGmxbjD3bZRpKEWJRjDmc5IhOTVibXnud{BjgSCZZYP0[ZJvKGKub4SgcYV1cG:m MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzN7Nk[xNEc,Ojd|OU[2NVA9N2F-
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... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 9 mg/mL (15.1 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 595.71
Formula

C29H37N7O5S

CAS No. 1421373-66-1
Storage powder
in solvent
Synonyms AZD9291 mesylate
Smiles CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC.CS(=O)(=O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID