Oltipraz

Catalog No.S7864

For research use only.

Oltipraz is a potent Nrf2 activator and a potent inducer of Phase II detoxification enzymes, most notably glutathione-S-transferase (GST). Phase 3.

Oltipraz Chemical Structure

CAS No. 64224-21-1

Selleck's Oltipraz has been cited by 6 Publications

1 Customer Review

Purity & Quality Control

Choose Selective Nrf2 Inhibitors

Biological Activity

Description Oltipraz is a potent Nrf2 activator and a potent inducer of Phase II detoxification enzymes, most notably glutathione-S-transferase (GST). Phase 3.
Targets
Nrf2 [1]
In vitro

Oltipraz, as a chemoprotective agent, induces Phase II detoxification enzyme activity in a Nrf2-dependent manner. [1] In human HT29 colon cancer cells, oltipraz inhibits the induction of HIF-1α by insulin, hypoxia or CoCl2 by significantly accelerating degradation of HIF-1α protein. [2]

In vivo Oltipraz (500 mg/kg, p.o.) significantly reduces multiplicity of gastric neoplasia in wild-type mice by 55%, but has no effect on tumor burden in nrf2-deficient mice. [1] In BALB/c nude mice transplanted with HCT116 cells, Oltipraz (200 mg/kg, p.o.) inhibits tumor growth and angiogenesis via inhibition of HIF-1α. [2] In rats on a CDAA diet, Oltipraz attenuate the progression of nonalcoholic steatohepatitis-related fibrosis. [3]

Protocol (from reference)

Animal Research:[1]
  • Animal Models: Female wild-type and nrf2-disrupted mice
  • Dosages: 500 mg/kg
  • Administration: p.o.

Solubility (25°C)

In vitro

DMSO 39 mg/mL warmed
(172.3 mM)
Water Insoluble
Ethanol Insoluble

Chemical Information

Molecular Weight 226.34
Formula

C8H6N2S3

CAS No. 64224-21-1
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=C(SSC1=S)C2=NC=CN=C2

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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