ONX-0914 (PR-957)

For research use only.

Catalog No.S7172

14 publications

ONX-0914 (PR-957) Chemical Structure

CAS No. 960374-59-8

ONX-0914 (PR-957) is a potent and selective immunoproteasome inhibitor with minimal cross-reactivity for the constitutive proteasome in a cell-free assay.

Selleck's ONX-0914 (PR-957) has been cited by 14 publications

2 Customer Reviews

  • Dependence of SPRI signal on receptor concentration: (a) ONX 0914 inhibitor, (b) inhibitor 5. 20Si concentration: 2.8 μg/mL, pH 7.4

    Cell Mol Bioeng, 2017, 10(2):174-185. ONX-0914 (PR-957) purchased from Selleck.

  • Mice were treated with daily doses of 10 mg/kg ONX-0914 iv or vehicle (n = 5–6). Not significant by log-rank test.

    Parasite Immunol, 2015, 37(11):599-604.. ONX-0914 (PR-957) purchased from Selleck.

Purity & Quality Control

Choose Selective Proteasome Inhibitors

Biological Activity

Description ONX-0914 (PR-957) is a potent and selective immunoproteasome inhibitor with minimal cross-reactivity for the constitutive proteasome in a cell-free assay.
Features The first highly selective, small molecule inhibitor of the immunoproteasome. Potential use in cancer and autoimmune diseases (e.g. rheumatoid arthritis, inflammatory bowel disease, and lupus).
Targets
LMP7 [1]
(Cell-free assay)
~10 nM
In vitro

ONX-0914 is 20- to 40-fold more selective for LMP7 over the next most sensitive sites, β5 or LMP2. ONX-0914 blocks presentation of LMP7-specific, MHC-I–restricted antigens in vitro and in vivo with minimal cross-reactivity for the constitutive proteasome. Selective inhibition of LMP7 by ONX-0914 blocks production of interleukin-23 (IL-23) by activated monocytes and interferon-gamma and IL-2 by T cells. LMP7 inhibition blocks production of IL-23 by ~90% and of tumor necrosis factor-α (TNF-α) and IL-6 by ~50%.[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Raji NIrYNWtHfW6ldHnvckBie3OjeR?= NEHtdnBKdmirYnn0bY9vKG:oIIDyc5Rm[XOxbXWgd5VjfW6rdDDi[ZRiNTWrIHnuJIh2dWGwIGLhbokh[2WubIOgeZNqdmdiQl;ETXB[NU6FMEC1JIJ6KG[udX;y[ZNk\W62IHTlcpNqfG:vZYTyfUwhUUN3ME2wMlAxPTgQvF2= NXrsNmk4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWwNFY4PDZpPkK1NFA3PzR4PD;hQi=>
EBC1 NUDVU5VDSW62aYT1cY9zKGG|c3H5 NHjGUo0yPSCvZz;r[y=> NGjBe3I2KGSjeYO= NIX5V|JCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDFRmMyKGOnbHzzJJhmdm:pcnHmeIVlKGmwIFPEMVEhdnWmZTDtc5V{\SCjc4Pld5Nm\CCjczD0eY1weiC{ZXfy[ZN{cW:wIHH0JFE2KG2pL3vnMEBxdyCzZDDh[I1qdmm|dHXy[YQh\m:{IEWg[IF6eyCxbjDhcoQhOiCmYYnzJI9n\iC3cDD0c{A{OiCmYYnz NFT4bVI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUCwOlc1Pid-MkWwNFY4PDZ:L3G+
SJ-GBM2 NYG4cHpMeUiWUzDhd5NigQ>? M1LDbJFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCVSj3HRm0zKGOnbHzz NE[4VWE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUCwOlc1Pid-MkWwNFY4PDZ:L3G+
SK-N-SH NU\1VHNyeUiWUzDhd5NigQ>? NVjoVYxFeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IGPLMW4uW0hiY3XscJM> NV7adGRQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWwNFY4PDZpPkK1NFA3PzR4PD;hQi=>
RPMI8226 NGW3TFdHfW6ldHnvckBie3OjeR?= NX7DbmZXUW6qaXLpeIlwdiCxZjDwdo91\WG|b33lJJN2[nWwaYSgZoV1[S1zaTDpckBpfW2jbjDSVG1KQDJ{NjDj[YxteyC3c3nu[{BDV0SLUGmtUmMxODFiYomg[ox2d3Knc3PlcpQh\GWwc3n0c41mfHK7LDDJR|UxRTBwM{VOwG0> NXvZdZB{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWwNFY4PDZpPkK1NFA3PzR4PD;hQi=>
Raji M{DxXGZ2dmO2aX;uJIF{e2G7 NW\5W2tqUW6qaXLpeIlwdiCxZjDwdo91\WG|b33lJJN2[nWwaYSgZoV1[S1zaTDpckBpfW2jbjDSZYpqKGOnbHzzJJV{cW6pIFLPSGlRYS1iZYDvfI9ucWOrbjDifUBndHWxcnXzZ4VvfCCmZX7zbZRwdWW2comsJGlEPTB;MD60Ou69VQ>? MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTByNke0Okc,OjVyME[3OFY9N2F-
Raji M{LqbmZ2dmO2aX;uJIF{e2G7 MY\Jcohq[mm2aX;uJI9nKHC{b4TlZZNwdWVic4XieY5qfCCkZYThMVJqKGmwIHj1cYFvKFKjanmgZ4VtdHNidYPpcochSk:GSWDZMUBmeG:6b33pZ4lvKGK7IH\seY9z\XOlZX70JIRmdnOrdH;t[ZRzgSxiSVO1NF0xNjV7zszN NHLjVnE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUCwOlc1Pid-MkWwNFY4PDZ:L3G+
RPMI8226 M1zFZWZ2dmO2aX;uJIF{e2G7 NETCdnVKdmirYnn0bY9vKG:oIIDyc5Rm[XOxbXWgd5VjfW6rdDDi[ZRiNTKrIHnuJIh2dWGwIGLQUWk5OjJ4IHPlcIx{KHW|aX7nJGJQTEmSWT3ldI95d22rY3nuJIJ6KG[udX;y[ZNk\W62IHTlcpNqfG:vZYTyfUwhUUN3ME2wMlU6|ryP M1;LZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MEC2O|Q3Lz5{NUCwOlc1PjxxYU6=
Raji NX7FNJMxTnWwY4Tpc44h[XO|YYm= M1f3R2lvcGmkaYTpc44hd2ZiMkDzJJBzd3SnYYPvcYUhe3WkdX7peEBj\XSjLULjJIlvKGi3bXHuJHJicmliY3XscJMhfXOrbnegRm9FUVC\LTDldI95d22rY3nuJIJ6KG[udX;y[ZNk\W62IHTlcpNqfG:vZYTyfUwhUUN3ME2xMlHPxE1? MkS3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyME[3OFYoRjJ3MEC2O|Q3RC:jPh?=
RPMI8226 MUDGeY5kfGmxbjDhd5NigQ>? NYG3XY1oUW6qaXLpeIlwdiCxZjCyNJMheHKxdHXhd49u\SC|dXL1col1KGKndHGtNoMhcW5iaIXtZY4hWlCPSUiyNlYh[2WubIOgeZNqdmdiQl;ETXB[NWWyb4jvcYlkcW5iYomg[ox2d3Knc3PlcpQh\GWwc3n0c41mfHK7LDDJR|UxRTFwMd88US=> MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTByNke0Okc,OjVyME[3OFY9N2F-
SK-N-MC MkH1dWhVWyCjc4PhfS=> Mli2dWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohWHKrbXHyfUB{[3KnZX6g[o9zKFONLV6tUWMh[2WubIO= NHf1VoQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUOzPVI2Oid-MkmzN|kzPTJ:L3G+
RD NFnVc21yUFSVIHHzd4F6 NIXie2hyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiUlSgZ4VtdHN? MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTN|OUK1Nkc,Ojl|M{myOVI9N2F-
MG 63 (6-TG R) M1rh[JFJXFNiYYPzZZk> M{PYVJFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCPRzC2N{ApPi2WRzDSLUBk\Wyucx?= NXHSXFBbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmzN|kzPTJpPkK5N|M6OjV{PD;hQi=>
NCI-H727 MXrDfZRwfG:6aXPpeJkh[XO|YYm= MYi0PEBpenN? NEHzVXpEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBPS0lvSEeyO{Bk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkh[W[2ZYKgOFghcHK|IHL5JGhw\WOqc4SgN|M{PDJic4ThbY5qdmdiYnHz[YQhUEOVIHHzd4F6NCCHQ{WwQVAvO87:TR?= MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTN|OUK1Nkc,Ojl|M{myOVI9N2F-
PC3 MVHDfZRwfG:6aXPpeJkh[XO|YYm= NYnFeIJtPDhiaILz MXLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDQR|Mh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFQ5KGi{czDifUBJd2WlaIP0JFM{OzR{IIP0ZYlvcW6pIHLhd4VlKEiFUzDhd5NigSxiRVO1NF0xNjN|zszN MlPTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl|M{myOVIoRjJ7M{O5NlUzRC:jPh?=
HuH7 M{\mZWN6fG:2b4jpZ4l1gSCjc4PhfS=> MVG0PEBpenN? NVTndm9yS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUHWKNzDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{KGK7IFjv[YNpe3RiM{OzOFIhe3SjaX7pcoch[mG|ZXSgTGNUKGG|c3H5MEBGSzVyPUCuN|nPxE1? NIDsc2o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUOzPVI2Oid-MkmzN|kzPTJ:L3G+
Caco2 MUDDfZRwfG:6aXPpeJkh[XO|YYm= NFW3UZI1QCCqcoO= MnLzR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gR4FkdzJiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSCKb3XjbJN1KDN|M{SyJJN1[WmwaX7nJIJie2WmIFjDV{Bie3OjeTygSWM2OD1zLkROwG0> NHfydYs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUOzPVI2Oid-MkmzN|kzPTJ:L3G+
DAOY M2jWXJFJXFNiYYPzZZk> MlTwdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohWHKrbXHyfUB{[3KnZX6g[o9zKESDT2mgZ4VtdHN? MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODN6MEi2N{c,OzB|OEC4OlM9N2F-
A673 MVHxTHRUKGG|c3H5 NHTmOGRyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiQU[3N{Bk\Wyucx?= NEDQdmk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEO4NFg3Oyd-M{CzPFA5PjN:L3G+
Rh41 MmG0dWhVWyCjc4PhfS=> Mnj1dWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohWHKrbXHyfUB{[3KnZX6g[o9zKFKqNEGgZ4VtdHN? NH;5Uok9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEO4NFg3Oyd-M{CzPFA5PjN:L3G+
A20 M37ac2Z2dmO2aX;uJIF{e2G7 M3rBTGlvcGmkaYTpc44hd2ZiTF3QNkBqdiCvb4Xz[UBCOjBiY3XscJMh[nliRVzJV2EtKEmFNUC9NE4{OjkQvF2= NUftd215RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CzPFA5PjNpPkOwN|gxQDZ|PD;hQi=>
A20 M1PsZ2Z2dmO2aX;uJIF{e2G7 NVq4[o4{UW6qaXLpeIlwdiCxZjCyNHMheHKxdHXvd49u\SCkZYThJFUhcW5ibX;1d4UhSTJyIHPlcIx{KGK7IFXMTXNCNCCLQ{WwQVAvPDBzzszN MkSyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB|OEC4OlMoRjNyM{iwPFY{RC:jPh?=
MOLT4 M2TZbmZ2dmO2aX;uJIF{e2G7 M2jhVGlvcGmkaYTpc44hd2ZiMkDTJJBzd3Snb4PvcYUh[mW2YTC1JIlvKGi3bXHuJG1QVFR2IHPlcIx{KGK7IFXMTXNCNCCLQ{WwQVAvPDJ{zszN NH;qN5I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEO4NFg3Oyd-M{CzPFA5PjN:L3G+
A20 MU\GeY5kfGmxbjDhd5NigQ>? M2nCfmlvcGmkaYTpc44hd2ZiTVXDUFEhcW5ibX;1d4UhSTJyIHPlcIx{KGK7IFXMTXNCNCCLQ{WwQVAvPjl7zszN M{P1RlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyM{iwPFY{Lz5|MEO4NFg3OzxxYU6=
MOLT4 MXfGeY5kfGmxbjDhd5NigQ>? M1;BWWlvcGmkaYTpc44hd2ZiTVXDUFEhcW5iaIXtZY4hVU:OVESgZ4VtdHNiYomgSWxKW0FuIFnDOVA:OC57MENOwG0> MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODN6MEi2N{c,OzB|OEC4OlM9N2F-
A20 MlvZSpVv[3Srb36gZZN{[Xl? M4PjXmlvcGmkaYTpc44hd2ZiMkDTJJBzd3Snb4PvcYUh[mW2YTCyJIlvKG2xdYPlJGEzOCClZXzsd{BjgSCHTFnTRUwhUUN3ME2wMlkyO87:TR?= M17ZZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyM{iwPFY{Lz5|MEO4NFg3OzxxYU6=
MOLT4 NVHaVVA1TnWwY4Tpc44h[XO|YYm= M3fPeGlvcGmkaYTpc44hd2ZiMkDTJJBzd3Snb4PvcYUh[mW2YTCyJIlvKGi3bXHuJG1QVFR2IHPlcIx{KGK7IFXMTXNCNCCLQ{WwQVAvQTJ5zszN MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODN6MEi2N{c,OzB|OEC4OlM9N2F-
PBMC M3vFZmZ2dmO2aX;uJIF{e2G7 NFP1S4QyODBibl2= MWOzJJRwKDd{IHjydy=> M4rNXGlvcGmkaYTpc44hd2ZiMkDTJJBzd3SnYYPvcYUh[mW2YTC1bUBqdiCqdX3hckBRSk2FIHPlcIx{KGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kBRW02ENTDlfJBz\XO|aX;uJIF1KDFyMDDuUUBi\nSncjCzJJRwKDd{IHjyd{BjgSCUVD3QR3Ih[W6jbInzbZM> NXXWSod1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GyPFMzOjJpPkOxNlg{OjJ{PD;hQi=>
PBMC MnvYSpVv[3Srb36gZZN{[Xl? NIfh[FgyODBibl2= MmXwN{B1dyB5MjDodpM> Mlu4TY5pcWKrdHnvckBw\iB{MGOgdJJwfGWjc3;t[UBj\XSjIEXpJIlvKGi3bXHuJHBDVUNiY3XscJMh[XO|ZYPz[YQh[XNiaX7keYN1cW:wIH;mJHBUVUJ4IHX4dJJme3Orb36gZZQhOTByIH7NJIFnfGW{IEOgeI8hPzJiaILzJIJ6KFKWLWDDVkBidmGueYPpdy=> Mme3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF{OEOyNlIoRjNzMkizNlIzRC:jPh?=
PBMC MUjGeY5kfGmxbjDhd5NigQ>? NEXZ[VgyODBibl2= M3;3N|MhfG9iN{KgbJJ{ NV3TOJpmUW6qaXLpeIlwdiCxZjCyNHMheHKxdHXhd49u\SCkZYThJFVqKGmwIHj1cYFvKFCETVOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5lfWO2aX;uJI9nKFCVTVK3JIV5eHKnc4Ppc44h[XRiMUCwJI5OKGGodHXyJFMhfG9iN{KgbJJ{KGK7IGLUMXBEWiCvZYToc4Q> M3yy[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzMkizNlIzLz5|MUK4N|IzOjxxYU6=

... Click to View More Cell Line Experimental Data

In vivo In mouse models of rheumatoid arthritis and lupus, ONX-0914 treatment reverses signs of disease and results in reductions in cellular infiltration, cytokine production and autoantibody levels at well-tolerated doses. The maximum tolerated dose (MTD) of ONX-0914 in mice to be 30 mg/kg body weight. IFN-g release is inhibited by ~60% at LMP7-selective concentrations of ONX-0914 and by ~90% at higher concentrations. Production of IL-2 is also inhibited by ~50%.[1]

Protocol

Animal Research:[1]
- Collapse
  • Animal Models: collagen antibody–induced arthritis (CAIA) and collagen-induced arthritis (CIA)
  • Dosages: 2, 6 or 10 mg/kg
  • Administration: i.v.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (172.21 mM)
Ethanol 100 mg/mL (172.21 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+castor oil
For best results, use promptly after mixing.
10 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 580.67
Formula

C31H40N4O7

CAS No. 960374-59-8
Storage powder
in solvent
Synonyms N/A
Smiles CC(C(=O)NC(CC1=CC=C(C=C1)OC)C(=O)NC(CC2=CC=CC=C2)C(=O)C3(CO3)C)NC(=O)CN4CCOCC4

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Proteasome Signaling Pathway Map

Proteasome Inhibitors with Unique Features

Related Proteasome Products

Tags: buy ONX-0914 (PR-957) | ONX-0914 (PR-957) supplier | purchase ONX-0914 (PR-957) | ONX-0914 (PR-957) cost | ONX-0914 (PR-957) manufacturer | order ONX-0914 (PR-957) | ONX-0914 (PR-957) distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID