Omecamtiv mecarbil (CK-1827452)

For research use only.

Catalog No.S2623

15 publications

Omecamtiv mecarbil (CK-1827452) Chemical Structure

Molecular Weight(MW): 401.43

Omecamtiv mecarbil (CK-1827452) is a specific cardiac myosin activator and a clinical drug for left ventricular systolic heart failure. Phase 2.

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Selleck's Omecamtiv mecarbil (CK-1827452) has been cited by 15 publications

2 Customer Reviews

  • Normal and Mutation human iPSC-CMs Structure when Treated with Omecamtiv Mecarbil. Human iPSC-CMs were plated on 100 kPa flat PDMS and grown for five days and left untreated, treated acutely on day 5, or treated continuously from the time of plating with the myosin activator Omecamtiv Mecarbil. iPSC-CMs were then fixed and stained for actin filaments (phalloidin, red) and nucleus (DAPI, blue). (a, c, e) Normal and (b, d, f) Mutation untreated, acutely treated, and continuously treated iPSC-CMs.

    University of Illinois at Chicago 2014 Omecamtiv mecarbil (CK-1827452) purchased from Selleck.

  • Effects of omecamtiv mecarbil and blebbistatin on the ATPase activity of cardiomyofibrils A-C, steady-state ATPase rates for control, OM treated and BS treated CMFs at pCa 9 (A), pCa 6 (B) and pCa 4.3 (C). Values indicate means ± SEM (n = 4–8). D, dose–response curve for the effect of omecamtiv mecarbil on steady-state cardiomyofibriliar ATPase activity at pCa 4.3. Statistical significance of differences between groups were assessed by a one-way ANOVA with Turkey’s post hoc test: ∗∗P < 0.01; ∗∗∗P < 0.001.

    J Physiol, 2018, 596(1):31-46. Omecamtiv mecarbil (CK-1827452) purchased from Selleck.

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Biological Activity

Description Omecamtiv mecarbil (CK-1827452) is a specific cardiac myosin activator and a clinical drug for left ventricular systolic heart failure. Phase 2.
Myosin ATPase [1]
In vitro

In vitro, Omecamtiv mecarbil selectively activates cardiac myosin by increasing the myosin ATPase rate. [1] In isolated cardiac myocytes, Omecamtiv mecarbil results in increase of myocyte contractility and overcomes of the myosin inhibitor BDM without increasing the calcium transient or inhibiting the PDE pathway. [1]

In vivo Omecamtiv mecarbil significantly increases fractional shortening starting at 0.4 mM plasma concentrations in SD rats, sham animals and in rats with heart failure. [1] In conscious dogs with myocardial infarction (MI-sHF), Omecamtiv mecarbil leads to a significant increase in wall thickening (25%), stroke volume (44%), cardiac output (22%) and left ventricular (LV) systolic ejection time (26%). In addition, Omecamtiv mecarbil also results in the decreases of some hemodynamic parameters including heart rate, mean left atrial pressure, and LV end-diastolic pressure. In conscious dogs with left ventricular hypertrophy (LVH-sHF), Omecamtiv mecarbil leads to similar and not statistically different effects on hemodynamic parameters. [2]


Animal Research:[1]
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  • Animal Models: Sprague Dawley rats.
  • Dosages: ≤1.2 mg/kg/hour
  • Administration: Administered via i.v.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 80 mg/mL (199.28 mM)
Ethanol 6 mg/mL (14.94 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
1% DMSO+30% polyethylene glycol+1% Tween 80
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 401.43


CAS No. 873697-71-3
Storage powder
in solvent
Synonyms N/A
Smiles COC(=O)N1CCN(CC1)CC2=CC=CC(=C2F)NC(=O)NC3=CN=C(C)C=C3

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01786512 Completed Drug: Omecamtiv Mecarbil|Drug: Placebo Modified Release Oral Formulation|Left Ventricular Systolic Dysfunction|Chronic Heart Failure|History of Chronic Heart Failure|Left Ventricular Ejection Fraction|Pharmacokinetics|Echocardiogram Amgen|Cytokinetics February 26 2013 Phase 2
NCT01300013 Completed Drug: Placebo|Drug: Omecamtiv mecarbil Heart Failure Amgen|Cytokinetics April 2011 Phase 2
NCT01077167 Withdrawn Drug: Omecamtiv mecarbil Heart Failure Amgen July 2010 Phase 2
NCT00941681 Completed Drug: CK-1827452 Heart Failure Cytokinetics April 2009 Phase 2
NCT00748579 Terminated Drug: CK-1827452 Heart Failure Cytokinetics September 2008 Phase 2

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Frequently Asked Questions

  • Question 1:

    We would like to know the half-life of S2623, could you please provide some information?

  • Answer:

    In a press release from cytokinetics (, the company claimed that CK-1827452 has a sufficiently long half-life to support oral dosing. In a later press release (, cytokinetics updated clinical trail result and mentioned that the elimination half-life of CK-1827452 is 22 hours.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID