Catalog No.S2493 Synonyms: LY170053
Molecular Weight(MW): 312.43975
Olanzapine is a high affinity for 5-HT2 serotonin and D2 dopamine receptor antagonist.
Cited by 7 Publications
2 Customer Reviews
Punctuates of LC3 proteins in olanzapine-treated T98 and LN229 cells. Cells were incubated with olanzapine (0, 0.1M, 0.2mM) for 48h and then stained with the anti-LC3 antibody. Cells were examined by fluorescence confocal microscopy. Green: FITC-labeled LC3; Blue: DAPI-labeled nucleus. Magnification: x 400
Asian Pac J Cancer Prev 2014 15(19), 8107-13. Olanzapine purchased from Selleck.
Olanzapine and aripiprazole differentially regulate cellular glucose uptake of PBMC. Bar graphs depict cellular glucose uptake assessed by 18F-FDG in PBMC after 72 h of stimulation with the indicated concentrations of olanzapine (Olan, A) or aripiprazole (Arip, B) relative to corresponding DMSO controls (Ctrl) and normalized to protein content. Data are depicted as mean ± SD. P-values were computed by one-way ANOVA followed by Dunnett's Multiple Comparison Test. ***P < 0.001, **P < 0.01, *P < 0.05 versus control; results were obtained from n ¼ 4e6 independent cell isolations measured in duplicate.
J Psychiatr Res, 2017, 88:18-27. Olanzapine purchased from Selleck.
Purity & Quality Control
Choose Selective 5-HT Receptor Inhibitors
|Description||Olanzapine is a high affinity for 5-HT2 serotonin and D2 dopamine receptor antagonist.|
Olanzapine interacts with key receptors of interest in schizophrenia, having a nanomolar affinity for dopaminergic, serotonergic, alpha 1-adrenergic, and muscarinic receptors. Olanzapine has a receptor profile that is similar to that of clozapine: it is relatively nonselective at dopamine receptor subtypes and it shows selectivity for mesolimbic and mesocortical over striatal dopamine tracts (electrophysiology; Fos). 
|In vivo||Olanzapine is a potent antagonist at DA receptors (DOPAC levels; pergolide-stimulated increases in plasma corticosterone) and 5-HT receptors (quipazine-stimulated increases in corticosterone), but is weaker at alpha-adrenergic and muscarinic receptors.  Olanzapine combined with fluoxetine produces robust, sustained increases of extracellular levels of dopamine ([DA](ex)) and norepinephrine ([NE](ex)) up to 361% and 272% of the baseline in rat prefrontal cortex, respectively, which are significantly greater than either drug alone.  Olanzapine at 0.5 mg/kg, 3 mg/kg and 10 mg/kg (s.c.) dose-dependently increases the extracellular dopamine (DA) and norepinephrine (NE) levels in rat prefrontal cortex, nucleus accumbens and striatum. Olanzapine also increases extracellular levels of a DA metabolite, DOPAC, and tissue concentrations of a released DA metabolite, 3-methoxytyramine.  Olanzapine results in an 8-11% reduction in mean fresh brain weights as well as left cerebrum fresh weights and volumes in macaque monkeys.  Olanzapine results in substantial increases in adiposity: increased total body fat reflecting marked increases in subcutaneous and visceral adipose stores. Olanzapine results in marked hepatic insulin resistance. |
-  Bymaster FP, et al. J Clin Psychiatry, 1997, 58, 28-36.
-  Zhang W, et al. Neuropsychopharmacology, 2000, 23(3), 250-262.
-  Li XM, et al. Psychopharmacology (Berl), 1998, 136(2), 153-161.
|In vitro||DMSO||62 mg/mL (198.43 mM)|
|Ethanol||9 mg/mL (28.8 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04075955||Recruiting||Drug: Zyprexa® (OLANZapine 5MG)|Drug: Emend® (Aprepitant)||Chemotherapy-induced Nausea and Vomiting||CR-CSSS Champlain-Charles-Le Moyne||April 29 2019||Phase 3|
|NCT03118986||Recruiting||Drug: Olanzapine|Drug: Placebo Oral Tablet||Vomiting in Infants and/or Children|Nausea|Hematopoietic System--Cancer||The Hospital for Sick Children||August 10 2017||Phase 2|
|NCT03137121||Recruiting||Drug: Olanzapine|Other: Placebo||Advanced Cancer||University of Alabama at Birmingham|Mayo Clinic||May 17 2017||Phase 2|Phase 3|
|NCT02861859||Active not recruiting||Drug: Olanzapine|Drug: Olanzapine Placebo||Breast Cancer||Ottawa Hospital Research Institute||December 2016||Phase 3|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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