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Olodanrigan (EMA401)

Name: Olodanrigan (EMA401)
Brand: Selleck Chemicals
SKU: S0326
Rating: 5 (0 reviews)

Catalog No.S0326 Synonyms: PD-126055, (S) PD-126055

For research use only.

Olodanrigan (EMA401, PD-126055, (S) PD-126055) is a highly selective, orally active, peripherally restricted antagonist of angiotensin II type 2 receptor (AT2R). Olodanrigan (EMA401) analgesic action appears to involve the inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons.

CAS No. 1316755-16-4

Purity & Quality Control

Choose Selective Angiotensin Receptor Inhibitors

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Biological Activity

Description

Targets

AT2R ^[1]
()

Protocol (from reference)

References

[1] Andrew S C Rice, et al. Lancet. 2014 May 10;383(9929):1637-1647.

Chemical Information

Molecular Weight	507.58
Formula	C₃₂H₂₉NO₅
CAS No.	1316755-16-4
Storage	3 years	-20°C	powder
Storage	2 years	-80°C	in solvent
Smiles	COC1=C(C2=C(CN(C(C2)C(=O)O)C(=O)C(C3=CC=CC=C3)C4=CC=CC=C4)C=C1)OCC5=CC=CC=C5

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