Oxybutynin

Catalog No.S1754

For research use only.

Oxybutynin is a competitive antagonist of the M1, M2, and M3 subtypes of the muscarinic acetylcholine receptor, used to relieve urinary and bladder difficulties.

Oxybutynin  Chemical Structure

CAS No. 5633-20-5

Purity & Quality Control

Choose Selective AChR Inhibitors

Other AChR Products

Biological Activity

Description Oxybutynin is a competitive antagonist of the M1, M2, and M3 subtypes of the muscarinic acetylcholine receptor, used to relieve urinary and bladder difficulties.
Targets
AChR [1]
In vitro

Oxybutynin N-deethylation in human liver microsomes in vitro is potently inhibited by ketoconazole (IC50 4.5 mM), less and variably by itraconazole and not by quinidine or several other reference inhibitors, suggesting that CYP3A enzymes are predominant catalysts of the reaction. Oxybutynin inhibits CYP3A4- and CYP2D6- associated activities (testosterone 6 beta-hydroxylase and dextromethorphan O- demethylase, respectively) in human liver microsomes. Oxybutynin is predominantly metabolized by CYP3A4 and CYP3A5 but not by CYP2D6. [1] Oxybutynin (30, 100 nM) competitively antagonizes acetylcholine-induced contractions but does not alter those induced by histamine. Oxybutynin (up to 10 mM) induces a non-competitive depression of responses to both agonists and causes a parallel shift to the right of the Ca2+-induced contractions in taenia caeci strips bathed in a Ca2+-free, high-K+ medium. Oxybutynin (1-10 mM) impairs rhythmic muscular contractions in normal medium and after CaCl2 addition in Ca2+-free medium. [2] Oxybutynin increases the perfusion pressure starting at 100 mM in perfused rat liver. Oxybutynin also increases the perfusion pressure in the hepatic artery. [3]

In vivo Oxybutynin decreases significantly binding potential (BP) of (+)N-[(11)C]methyl-3-piperidyl benzilate ([(11)C](+)3-MPB) in the rat cerebral cortex and corpus striatum in a dose-dependent manner. [4] Oxybutynin induces a significant decrease in micturition pressure without changes in BVC in obstructed rats. [5]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 71 mg/mL
(198.6 mM)
Ethanol 71 mg/mL
(198.6 mM)
Water Insoluble

Chemical Information

Molecular Weight 357.49
Formula

C22H31NO3

CAS No. 5633-20-5
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCN(CC)CC#CCOC(=O)C(C1CCCCC1)(C2=CC=CC=C2)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04526353 Not yet recruiting Drug: Oxybutynin 1 mg/ml Syrup Male Urogenital Diseases University Hospital Bordeaux September 10 2020 Phase 2
NCT02522936 Withdrawn Drug: Biotene oral spray Overactive Bladder|Xerostomia|Compliance University of Southern California August 1 2018 Phase 4
NCT02099695 Withdrawn Drug: Oxybutynin|Drug: Placebo Hyperhidrosis Cristália Produtos Químicos Farmacêuticos Ltda.|Hospital Israelita Albert Einstein|University of Sao Paulo December 2015 Phase 3
NCT02327936 Completed Drug: Fesoterodine|Drug: Oxybutynin XL Overactive Bladder Stéphane Bolduc|Pfizer|CHU de Quebec-Universite Laval December 2014 Phase 3

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Oxybutynin | Oxybutynin ic50 | Oxybutynin price | Oxybutynin cost | Oxybutynin solubility dmso | Oxybutynin purchase | Oxybutynin manufacturer | Oxybutynin research buy | Oxybutynin order | Oxybutynin mouse | Oxybutynin chemical structure | Oxybutynin mw | Oxybutynin molecular weight | Oxybutynin datasheet | Oxybutynin supplier | Oxybutynin in vitro | Oxybutynin cell line | Oxybutynin concentration | Oxybutynin nmr