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Orforglipron (LY3502970) GLP-1R Agonist

Name: Orforglipron (LY3502970)
Brand: Selleck Chemicals
SKU: S9852
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S9852

Orforglipron(LY3502970) is a non-peptidal agonist of glucagon-like peptide 1(GLP-1) receptor. It can be used efficiently in glycemic control and weight reduction in type 2 diabetes mellitus (T2DM), obesity or both.

Chemical Structure

Molecular Weight: 882.96

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Quality Control

Batch: S985201 DMSO]100 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.00%

Cited in Nature Medicine for its top-tier quality
COA
HPLC
SDS/MSDS
Datasheet

99.00

Related Targets	CXCR Hedgehog/Smoothened PKA Adrenergic Receptor AChR 5-HT Receptor Histamine Receptor Dopamine Receptor Ras KRas
Other Glucagon Receptor Inhibitors	Avexitide Exendin-4 GLP-1 (7-37) V-0219 Adomeglivant DMB Shanzhiside methyl ester Retatrutide (LY3437943) Mazdutide (IBI362, LY330567) Apraglutide (FE 203799)

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (113.25 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	5.000mg/ml (5.66mM)	Taking the 1 mL working solution as an example, add 50 μL of 100 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.500mg/ml (0.57mM)	Taking the 1 mL working solution as an example, add 50 μL of 10 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	882.96	Formula	C₄₈H₄₈F₂N₁₀O₅	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	2212020-52-3	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Read more about storage stability stock solution CAS number

Mechanism of Action

Targets/IC₅₀/Ki	GLP-1 receptor
References	[1] https://pubmed.ncbi.nlm.nih.gov/37852529/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-08-24)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT07241390	RECRUITING	Atherosclerosis Cardiovascular Disease; Chronic Kidney Disease	Eli Lilly and Company	2025-12-01	PHASE3
NCT07729332	NOT_YET_RECRUITING	Obesity	Massachusetts General Hospital	2026-11-01	PHASE4
NCT07668336	NOT_YET_RECRUITING	Diabetes Mellitus, Type 2	Eli Lilly and Company	2026-09	PHASE3
NCT07739537	NOT_YET_RECRUITING	Diabete Type 2; Pharmacogenomic Drug Interaction	Massachusetts General Hospital	2026-10-01	PHASE4
NCT07794579	NOT_YET_RECRUITING	Overweight; Prediabetic State; Prehypertension; Obesity, Abdominal	Eli Lilly and Company	2026-09	PHASE3
NCT07223593	RECRUITING	Peripheral Arterial Disease	Eli Lilly and Company	2025-10-31	PHASE3

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Handling Instructions

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