For research use only.
CAS No. 526-18-1
Osalmid suppresses ribonucleotide reductase (RNR) activity in a concentration-dependent manner, with a 50% RR activity-inhibitory concentration (IC50) of 8.23 μM.
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|Description||Osalmid suppresses ribonucleotide reductase (RNR) activity in a concentration-dependent manner, with a 50% RR activity-inhibitory concentration (IC50) of 8.23 μM.|
Osalmid is shown to be 10-fold more active in inhibiting RR activity than hydroxyurea, and significantly inhibits HBV DNA and cccDNA synthesis in HepG2.2.15 cells. Osalmid significantly inhibits HBV DNA replication in a time- and dose-dependent manner.
|In vivo||Osalmid significantly reduces RR activity and HBV DNA replication in vivo.|
|In vitro||DMSO||45 mg/mL (196.3 mM)|
|Ethanol||45 mg/mL (196.3 mM)|
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|% DMSO % % Tween 80 % ddH2O|
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