Osimertinib (AZD9291)

Name: Osimertinib (AZD9291)
Brand: Selleck Chemicals
SKU: S7297
Rating: 5 (213 reviews)

For research use only.

Catalog No.S7297

213 publications

Osimertinib (AZD9291) Chemical Structure

CAS No. 1421373-65-0

Osimertinib (AZD9291) is an oral, irreversible, and mutant-selective EGFR inhibitor with IC50 of 12.92, 11.44 and 493.8 nM for Exon 19 deletion EGFR, L858R/T790M EGFR, and WT EGFR in LoVo cells, respectively. Phase 3.

Selleck's Osimertinib (AZD9291) has been cited by 213 publications

Cell, 2020, 182(5):1232-1251.e22

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Cancer Cell, 2020, 13;37(1):104-122e12

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Nat Med, 2019, 25(1):111-118

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Cancer Cell, 2019, 10.1016/j.ccell.2019.09.001

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Nat Med, 2018, 24(5):638-646

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Cancer Discov, 2015, 5(11):1155-63

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Cancer Discov, 2015, 5(7):713-22

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Cell Rep, 2021, 34(3):108647

PubMed: 33472066 ( click the link to review the publication )

Mol Cancer, 2021, 20(1):17

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EBioMedicine, 2021, 64:103220

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Acta Pharmacol Sin, 2021, 10.1038/s41401-020-00577-1

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Acta Neuropathol, 2020, 17

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Nat Commun, 2020, 11(1):4607

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Sci Immunol, 2020, 31;5(43) pii: eaav3937

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EMBO Mol Med, 2020, e11099

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Clin Cancer Res, 2020, 20 pii: clincanres

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Clin Cancer Res, 2020, 10.1158/1078-0432.CCR-19-2321

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Clin Cancer Res, 2020, 10.1158/1078-0432

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Theranostics, 2020, 15;10(14):6122-6135

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Cancer Res, 2020, 80(21):4655-4667

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Oncogene, 2020, 10.1038/s41388-020-01497-4

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Cancer Lett, 2020, 28;483:46-58

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Cancers (Basel), 2020, 13(1)E111

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Cancers (Basel), 2020, 12(3)

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Cell Death Dis, 2020, 14;11(4):230

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Br J Cancer, 2020, 22

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Signal Transduct Target Ther, 2020, 5(1):214

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Cancer Discov, 2020, 15 pii: CD-20-0116

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Hum Mol Genet, 2020, ddaa268

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Cancer Sci, 2020, 111(10):3813-3823

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Lung Cancer, 2020, 5;145:48-57

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Mol Cancer Res, 2020, 10.1158/1541-7786.MCR-20-0664

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Front Oncol, 2020, 9:1503

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J Cell Mol Med, 2020, 10.1111/jcmm.16135

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Sci Rep, 2020, 17;10(1):2735

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Ann Transl Med, 2020, 8(6):366

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Environ Toxicol, 2020, 10.1002/tox.22899

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Biochem Biophys Res Commun, 2020, 534:1-7

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J Oncol, 2020, 17;2020:6249829

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Hum Cell, 2020, 10.1007/s13577-020-00420-z

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J Med Invest, 2020, 67(3.4):343-350

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J Hematol Oncol, 2020, 13(1):169

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Cancer Sci, 2020, 111(7):2374-2384

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Nat Cancer, 2020, 1(3):359-369

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Front Cell Dev Biol, 2020, 8:652

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Pharmaceutics, 2020, 12(10)E939

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Cells, 2020, 9(12)E2596

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Acta Pharmacol Sin, 2020, 10.1038/s41401-020-0443-1

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Mol Cancer Res, 2020, 18(4):549-559

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Physiol Rep, 2020, 8(13):e14490

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Acta Pharmacol Sin, 2020, 10.1038/s41401-020-0457-8

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Sci Rep, 2020, 10(1):11236

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Food Funct, 2020, 11(3):2714-2724

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Viruses, 2020, 12(11)E1294

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Rapid Commun Mass Spectrom, 2020, 10.1002/rcm.8955

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J Thorac Oncol, 2020, 15(5):752-765

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Nat Commun, 2019, 10(1):2701

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J Thorac Oncol, 2019, 14(4):656-671

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Clin Cancer Res, 2019, 25(11):3329-3340

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Neuro Oncol, 2019, 10.1093/neuonc/noz206

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Cell Syst, 2019, 8(2):97-108

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Cell Syst, 2019, 10.1016/j.cels.2019.10.002

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Biomaterials, 2019, 219:119400

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Cancer Res, 2019, 10.1158/0008-5472.CAN-18-2808

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Int J Cancer, 2019, 145(5):1432-1444

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Oncogene, 2019, 38(5):656-670

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Oncogene, 2019, 38(37):6399-6413

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J Exp Clin Cancer Res, 2019, 38(1):481

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Cancers, 2019, 11(3)

PubMed: 30818860 ( click the link to review the publication )

Signal Transduct Target Ther, 2019,

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Acta Pharm Sin B, 2019, 9(6):1193-1203

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Mol Cancer Ther, 2019, 18(1):112-126

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Mol Cancer Ther, 2019, 18(9):1593-1601

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Am J Cancer Res, 2019, 9(8):1708-1721

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Lung Cancer, 2019, 127:146-152

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Lung Cancer, 2019, 137:85-93

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Cancer Sci, 2019, 110(11):3584-3594

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J Cell Mol Med, 2019, 23(11):7427-7437

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Sci Rep, 2019,

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Clin Lung Cancer, 2019, 20(3):167-177

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Int J Biol Sci, 2019, 15(12):2607-2614

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Respir Res, 2019, 20(1-:270

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Cancer Manag Res, 2019, 11:3419-3432

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Ann Transl Med, 2019, 7(22):651

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Toxicol Appl Pharmacol, 2019, 379:114662

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J Cell Biochem, 2019, 120(1):756-767

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Cell Biosci, 2019, 9:60

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Oncol Rep, 2019, 41(2):1059-1066

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Biomed Res Int, 2019, 2019:3129748

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Thorac Cancer, 2019, 10(10):1868-1878

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Breast Cancer (Dove Med Press), 2019, 11:231-241

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Oncol Lett, 2019, 18(1):955-961

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FEBS Open Bio, 2019, 9(10):1689-1704

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Cell Mol Gastroenterol Hepatol, 2019, 7(1):161-184

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J Thorac Oncol, 2019, 14(9):1556-1566

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JCI Insight, 2019, 4(21)

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Oncotarget, 2019, 10(26):2546-2560

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Sci Rep, 2019, 9(1):5692

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Transl Lung Cancer Res, 2019, 8(4):340-351

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Zhongguo Fei Ai Za Zhi, 2019, 22(5):264-270

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Nat Biomed Eng, 2018, 2(4):239-253

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Nat Commun, 2018, 9(1):4655

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J Thorac Oncol, 2018, 13(7):915-925

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Clin Cancer Res, 2018, 24(13):3097-3107

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Clin Cancer Res, 2018, 24(22):5610-5621

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Proc Natl Acad Sci U S A, 2018, 115(26):E6030-E6038

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Cancer Res, 2018, 10.1158/0008-5472.CAN-18-0505

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J Hematol Oncol, 2018, 11(1):109

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Sci Signal, 2018, 11(549)

PubMed: 30254057 ( click the link to review the publication )

EBioMedicine, 2018, 29:112-127

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FASEB J, 2018, 10.1096/fj.201800011R

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Mol Cancer Ther, 2018, 17(4):740-750

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Mol Cancer Ther, 2018, 17(10):2257-2265

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Endocr Relat Cancer, 2018, 25(1):99-109

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Neoplasia, 2018, 20(8):826-837

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Nanomedicine (Lond), 2018, 13(10):1107-1120

PubMed: 29874151 ( click the link to review the publication )

Lung Cancer, 2018, 126:72-79

PubMed: 30527195 ( click the link to review the publication )

Front Cell Neurosci, 2018, 12:21

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Sci Rep, 2018, 8(1):18043

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Cancer Commun (Lond), 2018, 38(1):19

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Invest New Drugs, 2018, 36(6):999-1005

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Cancer Biol Ther, 2018, 19(3):239-247

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J Cancer Res Clin Oncol, 2018, 10.1007/s00432-018-2668-7

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Cancer Med, 2018, 7(1):208-218

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Oncol Rep, 2018, 40(2):1046-1054

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Environ Toxicol, 2018, 33(11):1153-1159

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Radiat Res, 2018, 189(3):283-291

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Pharmazie, 2018, 73(11):630-634

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Sci Rep, 2018, 8(1):14896

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JCI Insight, 2018, 3(24)

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JCI Insight, 2018, 3(11)

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Oncotarget, 2018, 9(101):37520-37533

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Oncotarget, 2018, 9(76):34240-34258

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Oncotarget, 2018, 9(51):29680-29697

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Sci Rep, 2018, 8(1):14896

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Nanomedicine (Lond), 2018, 13(10):1107-1120

PubMed: 29874151 ( click the link to review the publication )

Sci Transl Med, 2017, 9(415)

PubMed: 29118262 ( click the link to review the publication )

Nat Commun, 2017, 8(1):410

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Nat Commun, 2017, 8:13897

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J Natl Cancer Inst, 2017, 1;109(9):djx014

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J Thorac Oncol, 2017, 12(5):884-889

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Clin Cancer Res, 2017, 23(12):3139-3149

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Genome Res, 2017, 27(4):613-625

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Genes Dev, 2017, 31(2):184-196

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Neuro Oncol, 2017, 19(12):1628-1639

PubMed: 28575494 ( click the link to review the publication )

Cancer Res, 2017, 77(11):2990-3000

PubMed: 28416483 ( click the link to review the publication )

Cancer Res, 2017, 77(13):3527-3539

PubMed: 28522751 ( click the link to review the publication )

Cancer Res, 2017, 10.1158/0008-5472

PubMed: 28202511 ( click the link to review the publication )

Cancer Res, 2017, 77(5):1200-1211

PubMed: 28082405 ( click the link to review the publication )

Cell Rep, 2017, 21(11):3298-3309

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Elife, 2017, 10.7554/eLife.21536

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J Med Chem, 2017, 60(17):7447-7458

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Arch Toxicol, 2017, 91(8):2921-2938

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Mol Cancer Ther, 2017,

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Mol Cancer Ther, 2017, 16(2):357-364

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Mol Cancer Ther, 2017, 16(10):2130-2143

PubMed: 28751539 ( click the link to review the publication )

Mol Cancer Ther, 2017, 16(11):2563-2571

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Mol Cancer Ther, 2017, 16(3):506-515

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Mol Cancer Ther, 2017,

PubMed: 27913578 ( click the link to review the publication )

Mol Oncol, 2017,

PubMed: 28388009 ( click the link to review the publication )

J Mol Biol, 2017, 429(14):2211-2230

PubMed: 28539250 ( click the link to review the publication )

Eur J Med Chem, 2017, 140:510-527

PubMed: 28987609 ( click the link to review the publication )

Transl Lung Cancer Res, 2017, 6(5):600-610

PubMed: 29114475 ( click the link to review the publication )

Mol Cancer Res, 2017, 15(7):915-928

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Mol Cancer Res, 2017, 15(11):1542-1550

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Mol Cancer Res, 2017, 15(7):852-861

PubMed: 28314843 ( click the link to review the publication )

Mol Pharm, 2017, 14(7):2368-2377

PubMed: 28597653 ( click the link to review the publication )

Lung Cancer, 2017, 108:96-102

PubMed: 28625657 ( click the link to review the publication )
Lung Cancer, 2017, 109:1-8

PubMed: 28577937 ( click the link to review the publication )

Toxicol Sci, 2017, 162(1):146-166

PubMed: 29106658 ( click the link to review the publication )

Sci Rep, 2017, 7:44089

PubMed: 28276478 ( click the link to review the publication )

Clin Lung Cancer, 2017, 18(3):281-285

PubMed: 28038979 ( click the link to review the publication )

Toxicol Appl Pharmacol, 2017, 321:18-26

PubMed: 28237877 ( click the link to review the publication )

Onco Targets Ther, 2017, 10:5281-5288

PubMed: 29138581 ( click the link to review the publication )

Oncol Lett, 2017, 14(4):4349-4354

PubMed: 28959367 ( click the link to review the publication )

J Vis Exp, 2017, (126)

PubMed: 28829429 ( click the link to review the publication )

Oncotarget, 2017, 8(62):105479-105491

PubMed: 29285266 ( click the link to review the publication )

Oncotarget, 2017, 8(41):70736-70751

PubMed: 29050315 ( click the link to review the publication )

Oncotarget, 2017, 9(2):1641-1655

PubMed: 29416720 ( click the link to review the publication )

Oncotarget, 2017, 8(29):47305-47316

PubMed: 28521301 ( click the link to review the publication )

Oncotarget, 2017, 8(55):93825-93838

PubMed: 29212192 ( click the link to review the publication )

Oncotarget, 2017, 8(22):36331-36338

PubMed: 28422737 ( click the link to review the publication )

Oncotarget, 2017, 8(65):109319-109331

PubMed: 29312610 ( click the link to review the publication )

Oncotarget, 2017, 8(62):104894-104912

PubMed: 29285221 ( click the link to review the publication )

Sci Rep, 2017, 7(1):15441

PubMed: 29133857 ( click the link to review the publication )

Oncotarget, 2017,

PubMed: 29050315 ( click the link to review the publication )

Sci Rep, 2017, 7:44206

PubMed: 28287179 ( click the link to review the publication )

Sci Rep, 2017, 7:44089

PubMed: 28276478 ( click the link to review the publication )

Oncotarget, 2017, 8(22):36331-36338

PubMed: 28422737 ( click the link to review the publication )

Oncotarget, 2017, 9(2):1641-1655

PubMed: 29416720 ( click the link to review the publication )

Mol Cell, 2016, 63(3):526-38

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Nat Commun, 2016, 7:11815

PubMed: 27283993 ( click the link to review the publication )
Cancer Immunol Res, 2016, 4(11):936-947

PubMed: 27680026 ( click the link to review the publication )

Oncogene, 2016, 10.1038/onc.2016.216

PubMed: 27345413 ( click the link to review the publication )

J Med Chem, 2016, 59(13):6187-200

PubMed: 27266526 ( click the link to review the publication )

Mol Cancer Ther, 2016, 15(12):3040-3054

PubMed: 27612490 ( click the link to review the publication )

Cancer Sci, 2016, 107(8):1134-40

PubMed: 27240419 ( click the link to review the publication )

Mol Pharm, 2016, 13(6):2117-25

PubMed: 27169328 ( click the link to review the publication )

Oncotarget, 2016, 7(4):3847-56

PubMed: 26716903 ( click the link to review the publication )

Oncotarget, 2016, 7(51):84951-84964

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Oncotarget, 2016, 7(30):47998-48010

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Oncotarget, 2016, 7(17):23608-32

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Sci Rep, 2016, 6:37997

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Oncotarget, 2016, 7(4):3847-56

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Clin Cancer Res, 2015, 21(23):5305-13

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Clin Cancer Res, 2015, 10.1158/1078-0432.CCR-15-0560

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Sci Signal, 2015, 8(379):ra53

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J Med Chem, 2015, 58(16):6589-606

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J Biol Chem, 2015, 290(28):17495-504

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PLoS One, 2015, 10(11):e0143333

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J Natl Compr Canc Netw, 2013, 11(10):1249-61

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Methods Mol Biol, 2011, 685:91-109

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Expert Opin Pharmacother, 2010, 11(8):1263-76

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Purity & Quality Control

Choose Selective EGFR Inhibitors

Biological Activity

Description

Features

Orally bioavailable mutant-selective EGFR inhibitor that has been tested in Phase III clinical trials for treatment of Non-Small Cell Lung Cancer.

Targets

L858R/T790M EGFR ^[1] (LoVo cells)	Exon 19 deletion EGFR ^[1] (LoVo cells)	WT EGFR ^[1] (LoVo cells)
11.44 nM	12.92 nM	493.8 nM

In vitro

AZD9291 shows significantly more potent inhibition of proliferation in mutant EGFR cell lines compared to wild-type in vitro. ^[2]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
PC-9/BRc1	M3WyRmZ2dmO2aX;uJGF{e2G7	MUS1NEBvVQ>?	MkPVNlQhcA>?	MmLFSG1UVw>?	MkfHbY5lfWOnczDlfJBz\XO\|aX;uJI9nKHSqZTDwdo9ieG:ydH;0bYMhSkOOLUKg[oFucWy7IH3lcYJmeiCESV2=	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTR5N{OyOUc,OjV2N{ezNlU9N2F-
PC-9/ERc1	MXPGeY5kfGmxbjDBd5NigQ>?	MXi1NEBvVQ>?	NXrhZYRHOjRiaB?=	M37nSGROW09?	M{Lqbolv\HWlZYOg[ZhxemW\|c3nvckBw\iC2aHWgdJJw[XCxcITveIlkKEKFTD2yJIZidWmueTDt[Y1j\XJiQlnN	NFHJcGg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUS3O\|MzPSd-MkW0O\|c{OjV:L3G+
VP-2	Mm\4SpVv[3Srb36gRZN{[Xl?	M4nkd\|UxKG6P	NHm1N3ozPCCq	MljlSG1UVw>?	NIKxNGlqdmS3Y3XzJIV5eHKnc4Ppc44hd2ZidHjlJJBzd2Gyb4D0c5Rq[yCEQ1ytNkBn[W2rbImgcYVu[mW{IFLJUS=>	MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTR5N{OyOUc,OjV2N{ezNlU9N2F-
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NCI-H1975	NVHGXGxPS3m2b4TvfIlkcXS7IHHzd4F6		NV;0Z4dkPzJiaB?=		NF;0eJJKSzVyIE2gNE4xPiEQvF2=	NVzibmZ3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0PFY6PTNpPkK5OFg3QTV\|PD;hQi=>
HCC827	M2rjTWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7				M1;rRmlEPTBiPTCwMlA3OTZizszN	Mly4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh2Mk[5PVYoRjJ6NEK2PVk3RC:jPh?=
NCI-H1975	M1TMZmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7				MVzJR\|UxKD1iMD6wOlch\|ryP	MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDR{Nkm5Okc,Ojh2Mk[5PVY9N2F-
HaCaT	NGqxZ2tHfW6ldHnvckBie3OjeR?=		MmL4N{Bp		M2HEc2lEPTBiPTCwMlA4OzdizszN	MmnwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd2M{O4NlkoRjJ5NEOzPFI6RC:jPh?=
NCI-H1975	MX\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>?		NHL5[5U4OiCq		NYHxOG55UUN3MDC9JFAvOTNizszN	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODR{OUm1Okc,OzB2Mkm5OVY9N2F-
A431	MX;GeY5kfGmxbjDhd5NigQ>?		MV6xJIg>		NV3nR3hnUUN3MDC9JFAvOTRzIN88US=>	MnjSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl3M{S5NlYoRjJ7NUO0PVI3RC:jPh?=
A549	NInrSFlHfW6ldHnvckBie3OjeR?=				MnvqTWM2OCB;IECuNVUh\|ryP	Mo\VQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ5NU[yNlIoRjJ4N{W2NlIzRC:jPh?=
Calu3	NV:4TXNES3m2b4TvfIlkcXS7IHHzd4F6		MmKyO\|IhcA>?		NILseGpIUTVyIE2gNE4zPjRizszN	MlXDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV{N{G5OlMoRjJ3MkexPVY{RC:jPh?=
Sf9	M1TVO2Z2dmO2aX;uJIF{e2G7		MVmyNEBucW6\|		NF;1b4JKSzVyIE2gNE4zPzhizszN	MmTXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh2OEKxOVEoRjJ6NEiyNVUyRC:jPh?=
BAF3	NH\J[GFHfW6ldHnvckBie3OjeR?=		MnTwO\|IhcA>?		MXrHTVUxKD1iMD6zJO69VQ>?	MkPIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh{OEKxNlIoRjJ6MkiyNVIzRC:jPh?=
BAF3	MoX4SpVv[3Srb36gZZN{[Xl?		NXTU[JY5PzJiaB?=		M{Lq[WdKPTBiPTCwMlMyKM7:TR?=	MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDJ6MkGyNkc,Ojh{OEKxNlI9N2F-
NCI-H460	MUTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>?		NXe2WIhGPzJiaB?=		NVWyUG5WUUN3MDC9JFAvPDF3OTFOwG0>	MnnwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh5MU[2OFEoRjJ6N{G2OlQyRC:jPh?=
LoVo	NV\sdoJNTnWwY4Tpc44h[XO\|YYm=		NHH0S4czKGh?		MVXJR\|UxKD1iMD60PEDPxE1?	M{HIclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4OU[4NlU{Lz5{Nkm2PFI2OzxxYU6=
LoVo	Mny2SpVv[3Srb36gZZN{[Xl?		MXSyJIg>		NH;mSZhKSzVyIE2gNE41QCEQvF2=	MoLiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7OU[yOlcoRjJ5OUm2NlY4RC:jPh?=
A549	MWrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>?		NF72Z204OiCq		M4q0UmlEPTBiPTCwMlQ5PiEQvF2=	NVLmT3B6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm1O\|YzPzJpPkK5OVc3Ojd{PD;hQi=>
BAF3	MX7GeY5kfGmxbjDhd5NigQ>?		NIjJW4k4OiCq		M{\XOWdKPTBiPTCwMlUh\|ryP	M3TjRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MkiyNVIzLz5{OEK4NlEzOjxxYU6=
A549	NGPTXWFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?=		NEDD[Ws4OiCq		M3:2V2lEPTBiPTCwMlU{KM7:TR?=	MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR4Nke3N{c,Ojl2Nk[3O\|M9N2F-
A549	MlvwR5l1d3SxeHnjbZR6KGG\|c3H5		M4rENlczKGh?		NGWwZmhKSzVyIE2gNE42OyEQvF2=	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTh3M{O0NEc,Ojl6NUOzOFA9N2F-
BAF3	MY\GeY5kfGmxbjDhd5NigQ>?		NV:5bHFyPzJiaB?=		NXTnOohYT0l3MDC9JFAvPTVizszN	MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDJ6MkGyNkc,Ojh{OEKxNlI9N2F-
BAF3	MYjGeY5kfGmxbjDhd5NigQ>?		NGXWOXc4OiCq		Ml65S2k2OCB;IECuOVYh\|ryP	MmS1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh{OEKxNlIoRjJ6MkiyNVIzRC:jPh?=
HEK293	M37yUGZ2dmO2aX;uJIF{e2G7				MnX4TWM2OCB;IECuOVch\|ryP	NUTmbVdCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki0NlY6QTZpPkK4OFI3QTl4PD;hQi=>
BAF3	M{LPXWZ2dmO2aX;uJIF{e2G7		MmrCO\|IhcA>?		M{TkPWdKPTBiPTCwMlU6KM7:TR?=	MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDJ6MkGyNkc,Ojh{OEKxNlI9N2F-
A431	NWrxZW1wSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO\|YYm=				NV7lfmpDUUN3MDC9JFAvPjF3NjFOwG0>	MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDR{Nkm5Okc,Ojh2Mk[5PVY9N2F-
HT-29	M1;hRWN6fG:2b4jpZ4l1gSCjc4PhfS=>		NGexN4Q4OiCq		NHHjbXpKSzVyIE2gNE43PSEQvF2=	MoCyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2OE[5OVMoRjJ7NEi2PVU{RC:jPh?=
A431	MXjGeY5kfGmxbjDhd5NigQ>?		NEDKW3M6PiCq		NX[0bZEzTUN3MDC9JFAvPjZ5IN88US=>	NWezSGpuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiyNlUzPjlpPkK4NlI2OjZ7PD;hQi=>
A431	NWXXO4YxSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO\|YYm=		NFnINYg6PiCq		M3rHdWVEPTBiPTCwMlY4KM7:TR?=	M2XGbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OEWzOVc2Lz5{OEi1N\|U4PTxxYU6=
A431	MYnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>?		M2XVcVczKGh?		MWXJR\|UxKD1iMD62PFUh\|ryP	NHLoV2k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUWzOFkzPid-Mkm1N\|Q6OjZ:L3G+
A431	NHfLSnZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?=		MkfYPVYhcA>?		NWDHRnE6TUN3MDC9JFAvPyEQvF2=	NH7RNWI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OE[wN\|k6OSd-Mki2NFM6QTF:L3G+
A549	NITBS\|BEgXSxdH;4bYNqfHliYYPzZZk>		M1HRZlczKGh?		MmjVTWM2OCB;IECuPFch\|ryP	MnHzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2OE[5OVMoRjJ7NEi2PVU{RC:jPh?=
A431	M4nseGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7		M2LBdVczKGh?		MofpTWM2OCB;IECuPFk{KM7:TR?=	MlvnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzM{G2N\|koRjJ5MUOxOlM6RC:jPh?=
BA/F3	M2rvNWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7		NWXhd2F5PzJiaB?=		NHOyfYFKSzVyIE2gNUDPxE1?	M4D1TFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MkW4OVIyLz5{NkK1PFUzOTxxYU6=
BAF3	MorjS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?		M4myclczKGh?		M{DnU2dKPTBiPTCxMlIh\|ryP	NFvNZXk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEK4NlEzOid-MkiyPFIyOjJ:L3G+
NCI-H2122	M4LjNmZ2dmO2aX;uJIF{e2G7		Mn61O\|IhcA>?		NWfqT4RKT0l3MDC9JFEvOiEQvF2=	MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDJ6MkGyNkc,Ojh{OEKxNlI9N2F-
A431	Mk\TRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl?		M4r4blczKGh?		M3HVR2lEPTBiPTCxMlI1KM7:TR?=	NUm5ZZRJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C0Nlk6PTZpPkOwOFI6QTV4PD;hQi=>
A431	M1TkTWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7		Ml;NO\|IhcA>?		M2q3XGlEPTBiPTCxMlI3KM7:TR?=	NXSyR\|dRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm3N\|AyQTJpPkK5O\|MxOTl{PD;hQi=>
A431	MkfNRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl?		M1zFXlczKGh?		MmfwTWM2OCB;IEGuOlA1KM7:TR?=	M4PQfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEOzOVc6Lz5{OECzN\|U4QTxxYU6=
A549	NYWxeGZnSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO\|YYm=		NIiwOYE6PiCq		MULFR\|UxKD1iMT64N{DPxE1?	NH;TN4c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEi1N\|U4PSd-Mki4OVM2PzV:L3G+
CHL	M2T5fWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		NV74d4t5PzJiaB?=		MnPYS2k2OCB;IEKuPUDPxE1?	MnfGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh{OEKxNlIoRjJ6MkiyNVIzRC:jPh?=
H1355	MXfGeY5kfGmxbjDhd5NigQ>?		NELsT5c4OiCq		Mn3IS2k2OCB;IEOg{txO	MlXhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh{OEKxNlIoRjJ6MkiyNVIzRC:jPh?=
H1703	NGrQfHFHfW6ldHnvckBie3OjeR?=		MkCyO\|IhcA>?		NXH6b4IzT0l3MDC9JFMvPSEQvF2=	NG\Je4w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEK4NlEzOid-MkiyPFIyOjJ:L3G+
A549	M3XCRWZ2dmO2aX;uJIF{e2G7		M3TzSlczKGh?		Mnv3S2k2OCB;IEOuOUDPxE1?	NVTE[XpoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiyPFIyOjJpPkK4NlgzOTJ{PD;hQi=>
CHO	M2jx[mdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		NWDnPZpDPzJiaB?=		MV\HTVUxKD1iND6yJO69VQ>?	NHjKe3g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEK4NlEzOid-MkiyPFIyOjJ:L3G+
BAF3	M4DDWmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7		MmG2O\|IhcA>?		MnrxTWM2OCB;IESuOlEh\|ryP	MlHMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB2Mkm5OVYoRjNyNEK5PVU3RC:jPh?=
BAF3	NHfvdGdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?=		MYO3NkBp		MYDJR\|UxKD1iNT6xOUDPxE1?	NXvBWVlmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C0Nlk6PTZpPkOwOFI6QTV4PD;hQi=>
BEAS2B	MWHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>?		MoPuO\|IhcA>?		NX\S[5dtUUN3MDC9JFE1NjlizszN	NUf1ZoJ7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki3NVY3PDFpPkK4O\|E3PjRzPD;hQi=>
NCI-H1975	MkHESpVv[3Srb36gZZN{[Xl?		NIfnUnEzKGh?		MYXJR\|UxKD1iMUWg{txO	NXXOR3pMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyO\|E6PjNpPkK1NlcyQTZ\|PD;hQi=>
PC9	NWnieo5KTnWwY4Tpc44h[XO\|YYm=		MUCyJIg>		MlLUTWM2OCB;IEG3JO69VQ>?	NVLoVWxrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyO\|E6PjNpPkK1NlcyQTZ\|PD;hQi=>
LoVo	NUHCcW1xTnWwY4Tpc44h[XO\|YYm=		MoKyNkBp		M160[mlEPTBiPTC0PFAh\|ryP	NIKxbYQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUK3NVk3Oyd-MkWyO\|E6PjN:L3G+
NCI-H1975	M3rhU2FvfGm2dX3vdkBi[3Srdnn0fUBie3OjeR?=				Mm[wRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTlPJMWgyQTd3IHPlcIx{KGijcnLvdolv\yCHR1\SJGw5PTiUL2S5O\|BOKGSxdXLs[UBufXSjboSgfIVvd2e{YX\0[YQhcW5iU1PJSEBud3W\|ZTDhd5Nme3OnZDDhd{B1fW2xcjDndo94fGhiaX7obYJqfGmxbjDheEAzNjVibXevb4cw\GG7LDDwc{By\CCob4KgO{Bl[Xm\|IILlcIF1cX[nIITvJINwdnS{b3y=	NV\5eG5rRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyO\|E6PjNpPkK1NlcyQTZ\|PD;hQi=>
rat hepatocytes	Ml75SpVv[3Srb36gZZN{[Xl?				NYTFW21HUW62cnnud4lkKGOuZXHyZY5k\SCrbjDyZZQhcGWyYYTvZ5l1\XNibXXhd5Vz\WRicHXyJFExLzZiY3XscJM>	MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTJ5MUm2N{c,OjV{N{G5OlM9N2F-
human hepatocytes	NFy0SmVHfW6ldHnvckBie3OjeR?=				M3LaOGlvfHKrboPpZ{BkdGWjcnHuZ4UhcW5iaIXtZY4hcGWyYYTvZ5l1\XNibXXhd5Vz\WRicHXyJFExLzZiY3XscJM>	M1LDfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MkexPVY{Lz5{NUK3NVk3OzxxYU6=
NCI-H1975	MmToRY51cXS3bX;yJIFkfGm4aYT5JIF{e2G7				NIfJSI9CdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDOR2kuUDF7N{WgZ4VtdHNiaHHyZo9zcW6pIFXHSnIhVDh3OGKvWFk4OE1iZH;1ZoxmKG23dHHueEB5\W6xZ4Lh[pRm\CCrbjDTR2lFKG2xdYPlJIF{e2W\|c3XkJIF{KHS3bX;yJIdzd3e2aDDpcohq[mm2aX;uJIF1KDVibXevb4cw\GG7LDDwc{By\CCob4KgO{Bl[Xm\|IILlcIF1cX[nIITvJINwdnS{b3y=	MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTJ5MUm2N{c,OjV{N{G5OlM9N2F-
NCI-H1975	MmX6SpVv[3Srb36gZZN{[Xl?				NFrwUWFU\WynY4Tpeol1gSCrbnTlfEwhemG2aX:gc4YhUUN3MDDmc5IhTUeIUjDUO\|kxVS:OOEW4VkBld3WkbHWgcZV1[W62IHX4dJJme3OrbnegbJVu[W5iTlPJMWgyQTd3IHPlcIx{KHSxIFnDOVAh\m:{IIfpcIQhfHmyZTDFS2ZTKGW6cILld5NqdmdiaIXtZY4hSTR\|MTDj[Yxtew>?	MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTd\|MEG5Nkc,Ojl5M{CxPVI9N2F-
NCI-H1975	M3rSU2FvfGm2dX3vdkBi[3Srdnn0fUBie3OjeR?=				NWSySYJlSW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhTUeIUjDUO\|kxVS:OOEW4VkBld3WkbHWgcZV1[W62IHX4dJJme3OrbnegbJVu[W5iTlPJMWgyQTd3IHPlcIx{KHinbn;ndoFnfGWmIHnuJGJCVEJxYzDheIh6dWmlIH71[IUhdW:3c3WgZZN{\XO\|ZXSgZZMhfHWvb4Kg[5Jwf3SqIHnubIljcXSrb36gZZQhOTBibXevb4ctKHCxIHLp[EBnd3JiMkGg[IF6ew>?	M1;vRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7N{OwNVkzLz5{OUezNFE6OjxxYU6=
HCC827	NUHNW4xuSXCxcITvd4l{KGG\|c3H5				NIn3bVBKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m\|IHnuJIh2dWGwIFjDR\|gzPyClZXzsd{Bp[XKkb4LpcochTUeIUjDFO\|Q3NUF5NUCg[IVt\XSrb36gcZV1[W62IHHzd4V{e2WmIHHzJIViemy7IHHwc5B1d3SrYzDj[YxteyCjdDCzJJVOKGGodHXyJFI1KGi{czDifUBCdm6neHnuJHYuTkmWQz;wdo9xcWSrdX2gbY9lcWSnIIP0ZYlvcW6pIHLhd4VlKG[ub4egZ5l1d22ndIL5JEhTfmJiPTCxMlM1LSl?	NXW4WXFYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0OlY4PzNpPkK5OFY3Pzd\|PD;hQi=>
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A549	NVP2coV[TnWwY4Tpc44h[XO\|YYm=				NEf0eVhU\WynY4Tpeol1gSC{YYTpc{Bw\iCLQ{WwJIZweiCqdX3hckBCPTR7IHPlcIx{KGW6cILld5Nqdmdid3ns[E11gXCnIFXHSnIwUy2UYYOgcZV1[W62IITvJGlEPTBiZn;yJIh2dWGwIF7DTU1JOTl5NTDj[YxteyCneIDy[ZN{cW6pIFXHSnIhVDh3OGKvWFc6OE1iZH;1ZoxmKG23dHHueC=>	NGfk[no9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUS4Olk2Oyd-Mkm0PFY6PTN:L3G+
HCC827	NYTZfWN5SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO\|YYm=		NEfjZnk4OiCq		NH34VY9CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjDR\|gzPyClZXzsd{BifCBzIIXNJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO\|YYmgdoVt[XSrdnWgeI8h[2:wdILvcC=>	M2\GWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NUe2NlczLz5{OUW3OlI4OjxxYU6=
BAF3	MnjCSpVv[3Srb36gZZN{[Xl?		NEnUTGUzKGh?		MnLXTY5pcWKrdHnvckBw\iCHR1\SJHQ4QTCPL1y4OVhTN0N5OUfTJI12fGGwdDCoeY5sdm:5bjDvdolocW5rIHX4dJJme3OnZDDpckBud3W\|ZTDCRWY{KGOnbHzzJIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCrbjDFS2YucW6mdXPl[EBz\WOncITvdkBxcG:\|cHjvdplt[XSrb36gZZQhOSC2bzCzJJVOKHC{ZXnuZ5Vj[XSnZDDmc5IhOiCqcoOg[o9tdG:5ZXSgZpkhTUeIIIP0bY12dGG2aX;uJIZweiBzNTDtbY5{KGK7IGfld5Rmem5iYnzveEBidmGueYPpdy=>	MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODR{OUm1Okc,OzB2Mkm5OVY9N2F-
BAF3	NXzjcplYTnWwY4Tpc44h[XO\|YYm=		MUeyJIg>		M{\XXmlvcGmkaYTpc44hd2ZiRVfGVkAyQURxVEe5NG0wSzd7N2OgcZV1[W62IDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJI1wfXOnIFLBSlMh[2WubIOgZZN{\XO\|ZXSgZZMhemWmdXP0bY9vKGmwIFXHSk1qdmS3Y3XkJJJm[2WydH;yJJBpd3OyaH;yfYxifGmxbjDheEAyKHSxIEOgeW0heHKnaX7jeYJifGWmIH\vdkAzKGi{czDmc4xtd3enZDDifUBGT0Zic4TpcZVt[XSrb36g[o9zKDF3IH3pcpMh[nliV3XzeIVzdiCkbH;0JIFv[Wy7c3nz	NH\TNo89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MESyPVk2Pid-M{C0Nlk6PTZ:L3G+
NCI-H1975	M1vZ[2FvfGm2dX3vdkBi[3Srdnn0fUBie3OjeR?=				MnfDRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTlPJMWgyQTd3IHPlcIx{KHinbn;ndoFnfGWmIHnuJHNVV0ONLV\vfI4ydnVxTnr1JI52\GVibX;1d4Uh[XO\|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB1fW2xcjDndo94fGhiYYSgNlAhdWdxa3ev[IF6NCCybzDx[EBnd3JiMUSg[IF6eyC{ZXzheIl3\SC2bzD1cpRz\WG2ZXSgZ49vfHKxbB?=	NW\GNIJsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkizPVUzOTlpPkK4N\|k2OjF7PD;hQi=>
Caco2	M{DIfWZ2dmO2aX;uJIF{e2G7		M1W0TlIhcA>?		MUHF[oZtfXhicnH0bY8hd2ZiYYDwZZJmdnRicHXycYVi[mmuaYT5JIZzd21iYnHzc4xifGW{YXygd4ll\SC2bzDhdIlk[Wxic3nk[UBwfmW{IHHwbYNidCC\|aXTlJJRwKGKjc3;sZZRmemGuIIPp[IUhd3[ncjDpckBpfW2jbjDDZYNwOiClZXzsd{BifCB3IIXNJIlv[3WkYYTl[EBnd3JiMjDodpM>	NGrRPVE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEi1N\|U4PSd-Mki4OVM2PzV:L3G+
A431	NFKzdnRHfW6ldHnvckBie3OjeR?=				NH:4[3FU\WynY4Tpeol1gSC{YYTpc{Bw\iCHQ{WwJIZweiCqdX3hckBCPDNzIHPlcIx{KGW6cILld5Nqdmdid3ns[EB1gXCnIFXHSnIhfG9iRVO1NEBnd3JiaIXtZY4hVkOLLVixPVc2KGOnbHzzJIhiemKxcnnu[{BGT0[ULVy4OVhTN1R5OUDNJIRwfWKuZTDteZRidnR?	NFz0SJE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEi1N\|U4PSd-Mki4OVM2PzV:L3G+
Caco2	MonsSpVv[3Srb36gZZN{[Xl?		MlzvNkBp		NGXiTo1CeHCjcnXueEBx\XKvZXHibYxqfHliYXPyc5N{KGGyaXPhcEB1dyCkYYPvcIF1\XKjbDDzbYRmKGmwIHj1cYFvKEOjY3:yJINmdGy\|IHH0JFUhfU1iaX7jeYJifGWmIH\vdkAzKGi{cx?=	MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDh3M{W3OUc,Ojh6NUO1O\|U9N2F-
Caco2	NFT6NWtHfW6ldHnvckBie3OjeR?=		MUOyJIg>		MnTuRZBx[XKnboSgdIVzdWWjYnnsbZR6KGGlcn;zd{Bj[XOxbHH0[ZJidCC2bzDhdIlk[Wxic3nk[UBqdiCqdX3hckBE[WOxMjDj[YxteyCjdDC1JJVOKGmwY4XiZZRm\CCob4KgNkBpenN?	M2jub\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OEWzOVc2Lz5{OEi1N\|U4PTxxYU6=
NCI-H1975	MX7GeY5kfGmxbjDhd5NigQ>?		MnHCOEBp		M4DHXmlvcGmkaYTpc44hd2ZiRVfGVkBNQDV6Uj;UO\|kxVSCvdYThcpQhcW5iaIXtZY4hVkOLLVixPVc2KGOnbHzzJIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCrbjDBb5QheGixc4Doc5J6dGG2aX;uJIF1KFSqckOwPE9U\XJ2N{Ogd4l1\SCjdDCxJJVOKG2nYYP1doVlKGGodHXyJFQhcHK\|IHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqew>?	NYixVXZzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiyPFIyOjJpPkK4NlgzOTJ{PD;hQi=>
HCC827	MVTGeY5kfGmxbjDhd5NigQ>?		NV;JfJZmPCCq		M374TmlvcGmkaYTpc44hd2ZiRVfGVkBmgG:wIEG5JIRmdGW2aX;uJI12fGGwdDDpckBpfW2jbjDIR2M5OjdiY3XscJMh[XO\|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJGFsfCCyaH;zdIhwenmuYYTpc44h[XRiVHjyN\|A5N1OnckS3N{B{cXSnIHH0JFEhfU1ibXXhd5Vz\WRiYX\0[ZIhPCCqcoOgZpkhX2W\|dHXyckBjdG:2IHHuZYx6e2m\|	NHvh[mM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEK4NlEzOid-MkiyPFIyOjJ:L3G+
NCI-H1975	M1u2WGFxd3C2b4Ppd{Bie3OjeR?=		NYjjSXFMPDhiaB?=		NIfIWlBKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m\|IHnuJIh2dWGwIF7DTU1JOTl5NTDj[YxteyCqYYLic5JqdmdiRVfGVkBNQDV6Uj;UO\|kxVSCvdYThcpQh[XO\|ZYPz[YQh[XNiY3HzdIF{\TNiY3zlZZZi\2ViYYSgNUB2VSCjZoTldkA1QCCqcoOgZpkhcW2vdX7vZoxwfHSrbne=	Moj4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh{OEKxNlIoRjJ6MkiyNVIzRC:jPh?=
HCC827	NEfPXINCeG:ydH;zbZMh[XO\|YYm=		NInRdWU1QCCq		NEO1UZBKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m\|IHnuJIh2dWGwIFjDR\|gzPyClZXzsd{Bp[XKkb4LpcochTUeIUjDlfI9vKDF7IHTlcIV1cW:wIH31eIFvfCCjc4Pld5Nm\CCjczDjZZNx[XOnLUOgZ4xm[X[jZ3WgZZQhOSC3TTDh[pRmeiB2ODDodpMh[nliaX3teY5w[myxdITpcoc>	Mn\iQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh{OEKxNlIoRjJ6MkiyNVIzRC:jPh?=
PC9	NFPNNIZCeG:ydH;zbZMh[XO\|YYm=		Mk\YOFghcA>?		M2\xbGlv\HWldHnvckBw\iCjcH;weI9{cXNiaX6gbJVu[W5iUFO5JINmdGy\|IHjhdoJwemmwZzDFS2ZTKGW6b36gNVkh\GWuZYTpc44hdXW2YX70JIF{e2W\|c3XkJIF{KGOjc4Dhd4UuOyClbHXheoFo\SCjdDCxJJVOKGGodHXyJFQ5KGi{czDifUBqdW23bn;icI91fGmwZx?=	NVTx[49ORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiyPFIyOjJpPkK4NlgzOTJ{PD;hQi=>
H3255	M1SyfWFxd3C2b4Ppd{Bie3OjeR?=		MkfIOFghcA>?		MY\JcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIHj1cYFvKEh\|MkW1JINmdGy\|IHjhdoJwemmwZzDFS2ZTKEx6NUjSJI12fGGwdDDhd5Nme3OnZDDhd{Bk[XOyYYPlMVMh[2ynYY\h[4Uh[XRiMTD1UUBi\nSncjC0PEBpenNiYomgbY1ufW6xYnzveJRqdmd?	MoP5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh{OEKxNlIoRjJ6MkiyNVIzRC:jPh?=
NCI-H1975	MYPBdI9xfG:\|aYOgZZN{[Xl?		MU[0PEBp		M{[4SGlv\HWldHnvckBw\iCjcH;weI9{cXNiaX6gbJVu[W5iTlPJMWgyQTd3IHPlcIx{KGijcnLvdolv\yCHR1\SJGw5PTiUL2S3PVBOKG23dHHueEBie3Onc4Pl[EBieyCSQWLQJINt\WG4YXflJIF1KDFidV2gZYZ1\XJiNEigbJJ{KGK7IHntcZVvd2Kub4T0bY5o	MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDJ6MkGyNkc,Ojh{OEKxNlI9N2F-
PC9	MYPBdI9xfG:\|aYOgZZN{[Xl?		M2q1d\|Q5KGh?		NIHNNmtKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m\|IHnuJIh2dWGwIGDDPUBk\WyuczDoZZJjd3KrbnegSWdHWiCneH;uJFE6KGSnbHX0bY9vKG23dHHueEBie3Onc4Pl[EBieyCSQWLQJINt\WG4YXflJIF1KDFidV2gZYZ1\XJiNEigbJJ{KGK7IHntcZVvd2Kub4T0bY5o	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDJ6MkGyNkc,Ojh{OEKxNlI9N2F-
HCC827	MkTXRZBweHSxc3nzJIF{e2G7		MoPXOFghcA>?		NEW5e4hKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m\|IHnuJIh2dWGwIFjDR\|gzPyClZXzsd{Bp[XKkb4LpcochTUeIUjDlfI9vKDF7IHTlcIV1cW:wIH31eIFvfCCjc4Pld5Nm\CCjczDQRXJRKGOuZXH2ZYdmKGG2IEGgeW0h[W[2ZYKgOFghcHK\|IHL5JIludXWwb3Lsc5R1cW6p	M13ZTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MkiyNVIzLz5{OEK4NlEzOjxxYU6=
H3255	M4rh[GFxd3C2b4Ppd{Bie3OjeR?=		MUS0PEBp		NXXOSGJlUW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckBpfW2jbjDIN\|I2PSClZXzsd{Bp[XKkb4LpcochTUeIUjDMPFU5WiCvdYThcpQh[XO\|ZYPz[YQh[XNiUFHSVEBkdGWjdnHn[UBifCBzIIXNJIFnfGW{IES4JIhzeyCkeTDpcY12dm:kbH;0eIlv\w>?	NXH6[ZI6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiyPFIyOjJpPkK4NlgzOTJ{PD;hQi=>
NCI-H1975	MlnmSpVv[3Srb36gZZN{[Xl?				MoL0V4Vt\WO2aY\peJkhemG2aX:gc4YhUUN3MDDmc5IhcHWvYX6gUmNKNUhzOUe1JINmdGy\|IHjhdoJwemmwZzDFS2ZTKEx6NUjSM3Q4QTCPIHTveYJt\SCvdYThcpQhfG9iSVO1NEBnd3JiaIXtZY4hSTR\|MTDj[YxteyCqYYLic5Jqdmdid3ns[E11gXCnIFXHSnI>	MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDR{Nkm5Okc,Ojh2Mk[5PVY9N2F-
human hepatocytes	MU\GeY5kfGmxbjDhd5NigQ>?				MkPwTY51emmwc3njJINt\WG{YX7j[UBqdiCqdX3hckBp\XCjdH;jfZRmeyCjc4Pld5Nm\CCyZYKgcYltdGmxbjDj[Yxtew>?	Ml\EQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh2Mk[5PVYoRjJ6NEK2PVk3RC:jPh?=
rat hepatocytes	NXfFUnk3TnWwY4Tpc44h[XO\|YYm=				MVTJcpRzcW6\|aXOgZ4xm[XKjbnPlJIlvKHKjdDDo[ZBifG:leYTld{Bie3Onc4Pl[EBx\XJibXnscIlwdiClZXzsdy=>	MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDR{Nkm5Okc,Ojh2Mk[5PVY9N2F-
A549, NCI-H1975	NUjSZpJZTnWwY4Tpc44h[XO\|YYm=				M1LBSnNmdGWldHn2bZR6KHKjdHnvJI9nKEmFNUCg[o9zKEWJRj3zeIlufWyjdHXkJJdqdGRidInw[UBGT0[UIHnuJIh2dWGwIFG1OFkh[2WubIOgeI8hUUN3MDDmc5IhTUeIUjDMPFU5Wi:WN{mwUUBld3WkbHWgcZV1[W62IHnuJIh2dWGwIF7DTU1JOTl5NTDj[Yxtew>?	MkThQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ5NU[yNlIoRjJ4N{W2NlIzRC:jPh?=
A549, PC9	MYnGeY5kfGmxbjDhd5NigQ>?				M4DmdnNmdGWldHn2bZR6KHKjdHnvJI9nKEmFNUCg[o9zKEWJRj3zeIlufWyjdHXkJJdqdGRidInw[UBGT0[UIHnuJIh2dWGwIFG1OFkh[2WubIOgeI8hUUN3MDDmc5IhTUeIUjDk[YxmfGmxbjDteZRidnRiaX6gbJVu[W5iUFO5JINmdGy\|	MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjd3NkKyNkc,OjZ5NU[yNlI9N2F-
HCC827	MofHRZBweHSxc3nzJIF{e2G7				NVnnbGhkUW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckBpfW2jbjDIR2M5OjdiY3XscJMhcGG{Yn;ybY5oKEWJRmKgSVc1PiC2bzDBO\|UxKGSnbHX0bY9vKG23dHHueEBie3Onc4Pl[EBieyCnYYLsfUBieG:ydH;0bYMh[2WubIOgZZQhOyC3TTDh[pRmeiB{NDDodpMh[nliQX7u[ZhqdiCYLV\JWGMweHKxcHnkbZVuKGmxZHnk[UB{fGGrbnnu[{Bj[XOnZDDmcI94KGO7dH;t[ZRzgSBqUo\iJF0hOS5\|NDD0c{AyNjZ5JTm=	MoW3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl6NUOzOFAoRjJ7OEWzN\|QxRC:jPh?=
NCI-H1975	NV7BZnVWTnWwY4Tpc44h[XO\|YYm=				NXSwR4ZSUW6qaXLpeIlwdiCxZjDFS2ZTKEx6NUjSM3Q4QTCPIHTveYJt\SCvdYThcpQheGixc4Doc5J6dGG2aX;uJIlvKEWJRj3zeIlufWyjdHXkJIh2dWGwIF7DTU1JOTl5NTDj[YxteyCjdDCxJJRwKDFyMDDuUUBjgSCZZYP0[ZJvKGKub4SgcYV1cG:m	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTlyNkGxOEc,Ojl7ME[xNVQ9N2F-
A431	NGKwT5dHfW6ldHnvckBie3OjeR?=				NV;YXnI5W2WuZXP0bZZqfHlicnH0bY8tKHKjdHnvJGlEPTBiZn;yJIh2dWGwIFG0N\|Eh[2WubIOgc5ZmemW6cILld5Nqdmdid3ns[E11gXCnIFXHSnIhfG9iSVO1NEBnd3JiaIXtZY4hVkOLLVixPVc2KGOnbHzzJIV5eHKnc4PpcochTUeIUjDUO\|kxVS:OOEW4VkBufXSjboS=	Mn3QQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzM{G2N\|koRjJ5MUOxOlM6RC:jPh?=
PC9	NHnkVZpCdnSrdIXtc5Ih[WO2aY\peJkh[XO\|YYm=				MlLtRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iUFO5JINmdGy\|IHjhdoJwemmwZzDFS2ZTKGW6b36gNVkh\GWuZYTpc44h[WO2aY\heIlv\yCvdYThcpQhgGWwb3fyZYZ1\WRiaX6gV2NKTCCvb4Xz[UBie3Onc4Pl[EBieyC2dX3vdkBoem:5dHigbY5pcWKrdHnvckBifCBzMDDt[{9s\y:mYYmsJJBwKHGmIH\vdkA4KGSjeYOgdoVt[XSrdnWgeI8h[2:wdILvcC=>	MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTJ5MUm2N{c,OjV{N{G5OlM9N2F-
A431	NV\lSoUySW62aYT1cY9zKGGldHn2bZR6KGG\|c3H5				M1j2NmFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG0N\|Eh[2WubIOgfIVvd2e{YX\0[YQhcW5iU1PJSEBud3W\|ZTDhd5Nme3OnZDDhd{B1fW2xcjDndo94fGhiaX7obYJqfGmxbjDheEA2KG2pL3vnM4RigSxicH:gdYQh\m:{IEeg[IF6eyC{ZXzheIl3\SC2bzDjc451em:u	MkP0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV{N{G5OlMoRjJ3MkexPVY{RC:jPh?=

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	p-EGFR / p-AKT / p-ERK; PubMed: 28416483 Cancer Res PC-9/BRc1 cells were treated with the indicated doses of osimertinib. Drugs were refreshed every 24 hours. Cellular lysates were probed with the indicated antibodies. Osim: osimertinib. ABCB1; PubMed: 27649127 Molecules The effect of osimertinib at 0.3 μM on the expression of ABCB1 was measured in KB-3-1 and KB-C2 cell lines for 0, 24, 48, and 72 h.	28416483 27649127
Growth inhibition assay	Cell viability; PubMed: 31043587 Cell Death Dis Cells were treated with gefitinib or osimertinib for 72 h. Cell viability was measured by MTT assay. P < 0.05, P < 0.01, **P < 0.005 by t-test.	31043587
Immunofluorescence	Ki67 / γH2AX / p16; PubMed: 29212784 EMBO Mol Med PC9ER cells were treated for 5 days with either 3×mAbs (20 μg/ml), saline (CTRL), or with a low dose of osimertinib (2.5 nM). Shown are representative images of cells fixed in paraformaldehyde and immunostained for KI67 (panel E), γH2AX (panel F), and p16 (panel G). DAPI counterstaining was used to follow nuclear localization. Scale bar, 20 μm. The box and whisker plots, where the ends of the box are the upper and lower quartiles, depict quantifications of results obtained in three independent experiments. P ≤ 0.01, *P ≤ 0.001, n = 4; one-way ANOVA with Tukey's test.	29212784

In vivo

AZD9291(5mg/kg p.o.) causes profound regression of tumors across EGFRm+ (PC9) and EGFRm+/T790M (H1975) tumor models with profound inhibition of EGFR phosphorylation and key downstream signaling pathways such as AKT and ERK in vivo. ^[2]

Protocol

Animal Research: ^[2]	- Collapse Animal Models: Mice bearing PC9 and H1975 xenograft tumors Dosages: ~5 mg/kg Administration: p.o. (Only for Reference)

References

Solubility (25°C)

In vitro	DMSO	99 mg/mL warmed (198.15 mM)
	Ethanol	43 mg/mL warmed (86.06 mM)
	Water	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 5%DMSO+40%PEG300+5%Tween80+50%ddH2O For best results, use promptly after mixing.	7.5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download Osimertinib (AZD9291) SDF

Molecular Weight	499.61
Formula	C₂₈ H₃₃ N₇ O₂
CAS No.	1421373-65-0
Storage	3 years-20°C powder 2 years-80°C in solvent
Synonyms	N/A
Smiles	CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage

mg/kg

Average weight of animals

Dosing volume per animal

Number of animals

Step 2: Enter the in vivo formulation (Different batches have different solubility ratios, please contact Selleck to provide you with the correct ratio)

% DMSO+ % + % Tween 80+ % ddH₂O

Calculate Reset

Calculation results:

Working concentration： mg/ml；

Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH₂O，mix and clarify.

Note：1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Bio Calculators

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

Serial Dilutions
Concertration (start):
Dilution-folds:

Computed Result

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2020-01-06)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT02841579	Completed	Drug: Osimertinib	Non-Small Cell Lung Cancer	MedSIR\|AstraZeneca	August 2016	Phase 2
NCT02771314	Active not recruiting	Drug: AZD9291	Non Small Cell Lung Cancer	Hellenic Oncology Research Group	August 2 2016	Phase 2
NCT02511106	Active not recruiting	Drug: AZD9291 80 mg/40 mg\|Drug: Placebo AZD9291 80 mg/40 mg	Stage IB-IIIA Non-small Cell Lung Carcinoma	AstraZeneca	October 21 2015	Phase 3
NCT02529995	Completed	Drug: AZD9291 40 mg\|Drug: AZD9291 80 mg	Carcinoma Non-Small-Cell Lung With EGFR Mutation Positive	AstraZeneca	August 24 2015	Phase 1
NCT02491944	Completed	Drug: AZD9291\|Drug: [14C]AZD9291	Oncology	AstraZeneca	July 2015	Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

Frequently Asked Questions

Question 1:
Can this formulation be used in mice? What are reconstitution instructions for in vivo with mice?
Answer:
Osimertinib can be used for animal study. The vehicle we suggest is: 1% DMSO+30% PEG 300+dd H2O at up to 30mg/ml.

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