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Oxybuprocaine HCl

Name: Oxybuprocaine HCl
Brand: Selleck Chemicals
SKU: S4229
Rating: 5 (1 reviews)

Synonyms: oxybuprocaine hydrochloride

Catalog No.S4229 Purity: 99.86%

Oxybuprocaine HCl(oxybuprocaine hydrochloride) is a local anesthetic, which is used especially in ophthalmology and otolaryngology. Oxybuprocaine binds to sodium channel and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions

Oxybuprocaine HCl Chemical Structure

CAS: 5987-82-6

Purity & Quality Control

Batch: S422901 DMSO] 69 mg/mL] false] Water] 69 mg/mL] false] Ethanol] 69 mg/mL] false Purity: 99.86%

99.86

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Signaling Pathway

Sodium Channel Signaling Pathway

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Biological Activity

Description	Oxybuprocaine HCl(oxybuprocaine hydrochloride) is a local anesthetic, which is used especially in ophthalmology and otolaryngology. Oxybuprocaine binds to sodium channel and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions

In vitro
In vitro	Oxybuprocaine binds to sodium channels and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions. Depolarization of the neuronal membrane is inhibited thereby blocking the initiation and conduction of nerve impulses. Oxybuprocaine acts like bupivacaine or lidocaine and produces dose-related spinal blockades of motor function, proprioception and nociception. ^[1]

References

[1] Hung CH, et al. Neurosci Lett, 2009, 454(3), 249-253.

Chemical Information & Solubility

Molecular Weight	344.88	Formula	C₁₇H₂₈N₂O₃.HCl
CAS No.	5987-82-6	SDF	Download Oxybuprocaine HCl SDF
Smiles	CCCCOC1=C(C=CC(=C1)C(=O)OCCN(CC)CC)N.Cl
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 69 mg/mL ( (200.06 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 69 mg/mL

Ethanol : 69 mg/mL

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In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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