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Oxybuprocaine HCl Sodium Channel inhibitor

Cat.No.S4229

Oxybuprocaine HCl(oxybuprocaine hydrochloride) is a local anesthetic, which is used especially in ophthalmology and otolaryngology. Oxybuprocaine binds to sodium channel and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions
Oxybuprocaine HCl Sodium Channel inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 344.88

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Quality Control

Batch: S422901 DMSO]69 mg/mL]false]Water]69 mg/mL]false]Ethanol]69 mg/mL]false Purity: 99.86%
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99.86

Solubility

In vitro
Batch:

DMSO : 69 mg/mL (200.06 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 69 mg/mL

Ethanol : 69 mg/mL

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In vivo
Batch:

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Chemical Information, Storage & Stability

Molecular Weight 344.88 Formula

C17H28N2O3.HCl

 Storage (From the date of receipt)
CAS No. 5987-82-6 Download SDF Storage of Stock Solutions

Synonyms oxybuprocaine hydrochloride Smiles CCCCOC1=C(C=CC(=C1)C(=O)OCCN(CC)CC)N.Cl

Mechanism of Action

In vitro

Oxybuprocaine binds to sodium channels and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions. Depolarization of the neuronal membrane is inhibited thereby blocking the initiation and conduction of nerve impulses. Oxybuprocaine acts like bupivacaine or lidocaine and produces dose-related spinal blockades of motor function, proprioception and nociception.

References

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