Name: ODM-207
Brand: Selleck Chemicals
SKU: E1095
Rating: 5 (1 reviews)

ODM-207 is a potent and selective BET inhibitor that is structurally unrelated to the benzodiazepine. ODM-207 also shows potent antiproliferative effects in patient-derived cancer cells and in xenograft models.

ODM-207 Chemical Structure

CAS: 1801503-93-4

Purity & Quality Control

Batch: E109501 DMSO] 38 mg/mL] false] Ethanol] 4 mg/mL] false] Water] Insoluble] false Purity: 99.80%

99.80

ODM-207 Related Products

Related Targets	BET p300/CBP BRPF bromodomain	Click to Expand
Related Compound Libraries	Kinase Inhibitor Library FDA-approved Drug Library Natural Product Library Bioactive Compound Library-I Bioactive Compound Library-Ⅱ	Click to Expand

Signaling Pathway

Epigenetic Reader Domain Signaling Pathway

Choose Selective Epigenetic Reader Domain Inhibitors

Biological Activity

Description

ODM-207 is a potent and selective BET inhibitor that is structurally unrelated to the benzodiazepine. ODM-207 also shows potent antiproliferative effects in patient-derived cancer cells and in xenograft models.

Targets

BET ^[1]

In vitro
In vitro	ODM-207 is a potent DNA damage responses (DDR) targeted drugs with an IC50 of 2.12 μM. RNAi inhibition of RAD52-dependent HR potentiates the efficacy of a novel BETi ODM-207 in cutaneous apocrine sweat gland carcinoma patient derived tumor cells .^[2]
Cell Research	Cell lines	Cutaneous apocrine sweat gland carcinoma patient derived tumor cells
	Concentrations	500 nM
	Incubation Time	48 h
	Method	Cells are exposed to 500 nM ODM-207 for 48 hours. Analysis of RNAi effects on cell viability are quantified on basis of cell counts, while the analysis of RNAi induced accumulation of DNA damage is performed with automated quantification of antibody detected nuclear γH2AX foci per cell.

References

Chemical Information & Solubility

Molecular Weight	375.42	Formula	C₂₂H₂₁N₃O₃
CAS No.	1801503-93-4	SDF	--
Smiles	COC1=C(C=C2C=C(C)C(=O)N(CC3=CC=CC=N3)C2=C1)C4=C(C)ON=C4C
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 38 mg/mL ( (101.21 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 4 mg/mL

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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