Ondansetron HCl

For research use only.

Catalog No.S1390 Synonyms: GR 38032F

2 publications

Ondansetron HCl Chemical Structure

Molecular Weight(MW): 329.82

Ondansetron is a serotonin 5-HT3 receptor antagonist, used to prevent nausea and vomiting caused by cancer chemotherapy, and radiation therapy.

Size Price Stock Quantity  
10mM (1mL in DMSO) USD 67 In stock
USD 70 In stock
USD 157 In stock
USD 270 In stock
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Selleck's Ondansetron HCl has been cited by 2 publications

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  • Mean (±SEM) cumulative 5-HT concentration–response curves in the absence and presence of 5-HT antagonists (n = >8). Responses are expressed as a percentage of the maximum response for each curve.

    Int J Urol, 2016, 23(11):946-951. Ondansetron HCl purchased from Selleck.

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Biological Activity

Description Ondansetron is a serotonin 5-HT3 receptor antagonist, used to prevent nausea and vomiting caused by cancer chemotherapy, and radiation therapy.
5-HT3 [1]
In vivo Ondansetron decreases the intensity of withdrawal signs such as increased defecation, jumping and wet-dog shakes, elevated the nociceptive threshold values which are decreased by precipitated withdrawal, but produces no change in urination, rectal temperature or salivation. [1] Ondansetron and granisetron significantly enhances gastric emptying of glass beads and improves cisplatin-induced slowing of gastric emptying in rats. [2] Ondansetron exhibits a biphasic dose-response profile in mice, with antidepressant-like effects peaking at 0.1 mg/kg, in the forced swim and tail suspension tests. Ondansetron pretreatment augments the antidepressant effects of fluoxetine and venlafaxine but does not influence the effects of desipramine or 8-hydroxy-2-(di-n-propylamino) tetralin. Ondansetron (10 mg/kg) reverses hyperactivity in the open field, and decreases the percentage entry and time spent in open arms in the elevated plus maze. [3] Ondansetron, a selective and potent 5HT3 receptor antagonist, is shown to be effective at blocking the amphetamine-induced disruption of LI at a dose of 0.01 mg/kg, but not at 0.1 mg/kg. Ondansetron is able to attenuate increases in dopamine activity, produces pharmacologically with amphetamine without affecting baseline dopamine activity. [4] Ondansetron facilitates performance in young adult and aged animals, and inhibits an impairment in habituation induced by scopolamine, electrolesions or ibotenic acid lesions of the nucleus basalis magnocellularis. Ondansetron and arecoline antagonizes a scopolamine-induced impairment. [5]


Solubility (25°C)

In vitro DMSO 66 mg/mL (200.1 mM)
Water 24 mg/mL (72.76 mM)
Ethanol 10 mg/mL (30.31 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 329.82


CAS No. 99614-01-4
Storage powder
in solvent
Synonyms GR 38032F
Smiles Cl.C[N]1C2=C(C(=O)C(CC2)C[N]3C=CN=C3C)C4=CC=CC=C14

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04167813 Not yet recruiting Drug: Ondansetron 8mg or matched placebo Parkinson''s Hallucinations University College London|MODEPHARMA Limited|PARKINSONS UK|PRIMENT|SEALED ENVELOPE|Wasdell Packaging Ltd|Custom Pharmaceuticals Limited April 1 2020 Phase 2
NCT04226170 Not yet recruiting Drug: DAS-001 Myasthenia Gravis DAS-MG Inc April 30 2020 Phase 2
NCT03785691 Recruiting Drug: Mirtazapine|Drug: Ondansetron|Drug: Placebo Hyperemesis Gravidarum|Nausea Gravidarum|Vomiting of Pregnancy Nordsjaellands Hospital|Bispebjerg Hospital|Aalborg University Hospital|Aarhus University Hospital|Herlev and Gentofte Hospital|Hvidovre University Hospital|Odense University Hospital|Rigshospitalet Denmark|Regionernes Medicinpulje|Kolding Sygehus March 1 2019 Phase 2
NCT03642964 Active not recruiting Drug: CTC-501 Major Depressive Disorder (MDD) Chase Therapeutics Corporation September 10 2018 Phase 2

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5-HT Receptor Signaling Pathway Map

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