Ondansetron HCl

Catalog No.S1390 Synonyms: GR 38032F

Ondansetron HCl Chemical Structure

Molecular Weight(MW): 329.82

Ondansetron is a serotonin 5-HT3 receptor antagonist, used to prevent nausea and vomiting caused by cancer chemotherapy, and radiation therapy.

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Cited by 1 Publication

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  • Mean (±SEM) cumulative 5-HT concentration–response curves in the absence and presence of 5-HT antagonists (n = >8). Responses are expressed as a percentage of the maximum response for each curve.

    Int J Urol, 2016, 23(11):946-951. Ondansetron HCl purchased from Selleck.

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Biological Activity

Description Ondansetron is a serotonin 5-HT3 receptor antagonist, used to prevent nausea and vomiting caused by cancer chemotherapy, and radiation therapy.
Targets
5-HT3 [1]
In vivo Ondansetron decreases the intensity of withdrawal signs such as increased defecation, jumping and wet-dog shakes, elevated the nociceptive threshold values which are decreased by precipitated withdrawal, but produces no change in urination, rectal temperature or salivation. [1] Ondansetron and granisetron significantly enhances gastric emptying of glass beads and improves cisplatin-induced slowing of gastric emptying in rats. [2] Ondansetron exhibits a biphasic dose-response profile in mice, with antidepressant-like effects peaking at 0.1 mg/kg, in the forced swim and tail suspension tests. Ondansetron pretreatment augments the antidepressant effects of fluoxetine and venlafaxine but does not influence the effects of desipramine or 8-hydroxy-2-(di-n-propylamino) tetralin. Ondansetron (10 mg/kg) reverses hyperactivity in the open field, and decreases the percentage entry and time spent in open arms in the elevated plus maze. [3] Ondansetron, a selective and potent 5HT3 receptor antagonist, is shown to be effective at blocking the amphetamine-induced disruption of LI at a dose of 0.01 mg/kg, but not at 0.1 mg/kg. Ondansetron is able to attenuate increases in dopamine activity, produces pharmacologically with amphetamine without affecting baseline dopamine activity. [4] Ondansetron facilitates performance in young adult and aged animals, and inhibits an impairment in habituation induced by scopolamine, electrolesions or ibotenic acid lesions of the nucleus basalis magnocellularis. Ondansetron and arecoline antagonizes a scopolamine-induced impairment. [5]

Protocol

Solubility (25°C)

In vitro DMSO 66 mg/mL (200.1 mM)
Water 24 mg/mL (72.76 mM)
Ethanol 10 mg/mL (30.31 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 329.82
Formula

C18H19N3O.HCl

CAS No. 99614-01-4
Storage powder
in solvent
Synonyms GR 38032F

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03817970 Not yet recruiting Nephrotoxicity University of Colorado Denver|Memorial Sloan Kettering Cancer Center|Rutgers University|National Institute of General Medical Sciences (NIGMS) April 25 2019 Not Applicable
NCT03817970 Not yet recruiting Nephrotoxicity University of Colorado Denver|Memorial Sloan Kettering Cancer Center|Rutgers University|National Institute of General Medical Sciences (NIGMS) April 25 2019 Not Applicable
NCT03865290 Recruiting Indigestion|Diabetes Mellitus Mayo Clinic|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) March 2019 Phase 2
NCT03785691 Recruiting Hyperemesis Gravidarum|Nausea Gravidarum|Vomiting of Pregnancy Nordsjaellands Hospital|Bispebjerg Hospital|Aalborg Universitetshospital|Aarhus University Hospital|Herlev and Gentofte Hospital|Hvidovre University Hospital|Odense University Hospital|Rigshospitalet Denmark|Regionernes Medicinpulje March 1 2019 Phase 2
NCT03809234 Recruiting Neuropathic Pain Washington University School of Medicine March 20 2019 Phase 1
NCT03851835 Not yet recruiting Acute Gastroenteritis|Viral Illness|Vomiting|Diarrhea University of Calgary|Canadian Institutes of Health Research (CIHR)|Women and Children''s Health Research Institute (WCHRI)|The Hospital for Sick Children|Children''s Hospital Research Institute of Manitoba|University of Manitoba|Université de Montréal|University of Ottawa|University of Alberta|Alberta Children''s Hospital Research Institute|University of Western Ontario Canada March 2019 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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5-HT Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID