For research use only.
Catalog No.S1830 Synonyms: RS-8858
CAS No. 53716-50-0
Oxfendazole (RS-8858) is a broad spectrum benzimidazole anthelmintic.
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|Description||Oxfendazole (RS-8858) is a broad spectrum benzimidazole anthelmintic.|
|In vivo||Oxfendazole (OX) induces not only mRNA expression of phase I enzymes Cyp1a1, Cyp1a2, but also Nrf2-regulated phase II enzymes such as Gpx2, Nqo1, Yc2, Akr7a3 and Gstm1 in rats, presumably due to an adaptive response against OX-induced oxidative stress. Oxfendazole enhances oxidative DNA damage (as assessed by 8-hydroxydeoxyguanosine; 8-OHdG) and lipid peroxidation (as assessed by thiobarbituric acid-reactive substances; TBARS) in rats.  Oxfendazole administered at the therapeutic dose (4.5 mg/kg) and at the highest dose (22.5 mg/kg) increase 1.54- and 2.36-fold the total liver microsomal cytochrome P450 and more particularly the isoenzyme P450IA2 (95% and 184% increases) in rabbit liver.  Oxfendazole MRL induces a mutagenic effect in all tested cell types. Oxfendazole exhibits embryotoxicity including teratogenicity. Oxfendazole induces a disturbance in the different biochemical contents of all tested tissues in mice.  Oxfendazole increases the incidence and multiplicity of altered foci (4.0- and 3.6-fold, respectively) and hepatocellular adenomas (HCAs) (3.0- and 5.5-fold, respectively). Oxfendazole treatment induces 5.2- and 5.6-fold increases in the number of proliferating cell nuclear antigen (PCNA)-positive cells and single-stranded DNA (ssDNA)-positive cells in HCAs compared with the surrounding tissue, respectively.  Oxfendazole and its sulphone metabolite attain a significantly higher plasma concentration and remain much longer in plasma compared with fenbendazole (FBZ) and albendazole (ABZ) and their respective metabolites in dogs. |
-  Dewa Y, et al. Arch Toxicol,?009, 83(5), 503-511.
-  Gleizes C, et al. Biochem Pharmacol,?991, 41(12), 1813-1820.
-  El-Makawy A, et al. Reprod Nutr Dev,?006, 46(2), 139-156.
|In vitro||DMSO||10 mg/mL (31.71 mM)|
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|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04920292||Not yet recruiting||Drug: Oxfendazole|Drug: Placebo||Filariasis||Swiss Tropical & Public Health Institute|Ifakara Health Institute|Drugs for Neglected Diseases||September 1 2021||Phase 1|
|NCT02636803||Withdrawn||Drug: oxfendazole|Drug: albendazole||Helminthiasis||Johns Hopkins Bloomberg School of Public Health|Universidad Peruana Cayetano Heredia||November 2019||Phase 2|
|NCT03035760||Completed||Drug: Oxfendazole||Helminthic Infection||National Institute of Allergy and Infectious Diseases (NIAID)||May 12 2017||Phase 1|
|NCT02234570||Completed||Drug: Oxfendazole|Other: Placebo||Neurocysticercosis||National Institute of Allergy and Infectious Diseases (NIAID)||November 17 2014||Phase 1|
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