For research use only.

Catalog No.S1830 Synonyms: RS-8858

1 publication

Oxfendazole Chemical Structure

CAS No. 53716-50-0

Oxfendazole (RS-8858) is a broad spectrum benzimidazole anthelmintic.

Selleck's Oxfendazole has been cited by 1 publication

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Biological Activity

Description Oxfendazole (RS-8858) is a broad spectrum benzimidazole anthelmintic.
In vivo Oxfendazole (OX) induces not only mRNA expression of phase I enzymes Cyp1a1, Cyp1a2, but also Nrf2-regulated phase II enzymes such as Gpx2, Nqo1, Yc2, Akr7a3 and Gstm1 in rats, presumably due to an adaptive response against OX-induced oxidative stress. Oxfendazole enhances oxidative DNA damage (as assessed by 8-hydroxydeoxyguanosine; 8-OHdG) and lipid peroxidation (as assessed by thiobarbituric acid-reactive substances; TBARS) in rats. [1] Oxfendazole administered at the therapeutic dose (4.5 mg/kg) and at the highest dose (22.5 mg/kg) increase 1.54- and 2.36-fold the total liver microsomal cytochrome P450 and more particularly the isoenzyme P450IA2 (95% and 184% increases) in rabbit liver. [2] Oxfendazole MRL induces a mutagenic effect in all tested cell types. Oxfendazole exhibits embryotoxicity including teratogenicity. Oxfendazole induces a disturbance in the different biochemical contents of all tested tissues in mice. [3] Oxfendazole increases the incidence and multiplicity of altered foci (4.0- and 3.6-fold, respectively) and hepatocellular adenomas (HCAs) (3.0- and 5.5-fold, respectively). Oxfendazole treatment induces 5.2- and 5.6-fold increases in the number of proliferating cell nuclear antigen (PCNA)-positive cells and single-stranded DNA (ssDNA)-positive cells in HCAs compared with the surrounding tissue, respectively. [4] Oxfendazole and its sulphone metabolite attain a significantly higher plasma concentration and remain much longer in plasma compared with fenbendazole (FBZ) and albendazole (ABZ) and their respective metabolites in dogs. [5]


Solubility (25°C)

In vitro DMSO 10 mg/mL (31.71 mM)
Water Insoluble
Ethanol Insoluble

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Chemical Information

Molecular Weight 315.35


CAS No. 53716-50-0
Storage powder
in solvent
Synonyms RS-8858
Smiles COC(=O)NC1=NC2=C(N1)C=C(C=C2)S(=O)C3=CC=CC=C3

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04920292 Not yet recruiting Drug: Oxfendazole|Drug: Placebo Filariasis Swiss Tropical & Public Health Institute|Ifakara Health Institute|Drugs for Neglected Diseases September 1 2021 Phase 1
NCT02636803 Withdrawn Drug: oxfendazole|Drug: albendazole Helminthiasis Johns Hopkins Bloomberg School of Public Health|Universidad Peruana Cayetano Heredia November 2019 Phase 2
NCT03035760 Completed Drug: Oxfendazole Helminthic Infection National Institute of Allergy and Infectious Diseases (NIAID) May 12 2017 Phase 1
NCT02234570 Completed Drug: Oxfendazole|Other: Placebo Neurocysticercosis National Institute of Allergy and Infectious Diseases (NIAID) November 17 2014 Phase 1

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID