For research use only. Not for use in humans.

Omalizumab (anti-IgE)

Synonyms: Olizumab, rhuMab-E25 Cat.No.A2044 Purity:99%

Omalizumab is a recombinant, humanized, monoclonal antibody against human immunoglobulin E (IgE) with a K_D of 0.393 nM. Omalizumab binds to the human FcγRIIb receptors with a K_D of 6.37 uM. Omalizumab has the potential for persistent allergic asthma research.

Click to purchase the isotype control of Omalizumab (anti-IgE)

Quality Control

Batch: Purity: 99% Protein concentration: 12.415mg/ml Endotoxin Level: ＜1EU/mg

Specificity

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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description	Omalizumab is a recombinant, humanized, monoclonal antibody against human immunoglobulin E (IgE) with a K_D of 0.393 nM. Omalizumab binds to the human FcγRIIb receptors with a K_D of 6.37 uM. Omalizumab has the potential for persistent allergic asthma research.
In vivo	Omalizumab (anti-IgE) is effective in controlling the allergic symptoms of allergic rhinitis by lowering inflammatory mediator CysLT levels of nasal lavage in an experimental allergic rhinitis model.^[1]
Animal Research	Animal models: Sprague Dawley rats Dosages: 0.5mg Administration: s.c. [1]
References	[1] https://pubmed.ncbi.nlm.nih.gov/25558647/

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	242138-07-4
Isotype	Human IgG1
Application	Omalizumab (anti-IgE)
Sterility	0.2 μM filtered
Formulation	100 mM Pro-Ac, 20 mM Arg, pH 5.0
Storage (From the date of receipt)	Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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