Ozanimod (RPC1063)

Catalog No.S7952

For research use only.

Ozanimod (RPC1063) is a selective oral S1P Receptor 1 modulator. Phase 3.

Ozanimod (RPC1063) Chemical Structure

CAS No. 1306760-87-1

Selleck's Ozanimod (RPC1063) has been cited by 6 Publications

Purity & Quality Control

Choose Selective S1P Receptor Inhibitors

Other S1P Receptor Products

Biological Activity

Description Ozanimod (RPC1063) is a selective oral S1P Receptor 1 modulator. Phase 3.
S1P1R [1]
(Cell-free assay)
S1P5R [1]
(Cell-free assay)
0.41 nM(EC50) 11 nM(EC50)
In vitro

In S1P1R-HEK293T cells, Ozanimod induces sustained S1P1R internalization and degradation. [1]

In vivo In vivo, Ozanimod shows high oral bioavailability and volume of distribution. In a MOG-induced EAE mouse model, Ozanimod (3 mg/kg, p.o.) suppresses clinical symptoms. In a rat TNBS model of inflammatory bowel disease, Ozanimod (1.2 mg/kg, p.o.) inhibits clinical and histological disease scores. In a Naïve CD4+CD45Rbhi T cell adoptive transfer model, Ozanimod (1.2 mg/kg, p.o.) also significantly reduced disease severity as assessed by measuring the degree of inflammation, gland loss, hyperplasia, neutrophil infiltrate and mucosal thickness. [1]

Protocol (from reference)

Animal Research:[1]
  • Animal Models: MOG-induced EAE model in C57Bl6 mice, TNBS model of inflammatory bowel disease in male Sprague Dawley rats, and Na飗e CD4+CD45Rbhi T cell adoptive transfer model in SCID mice
  • Dosages: 0.1-3 mg/kg
  • Administration: p.o.

Solubility (25°C)

In vitro

DMSO 81 mg/mL
(200.26 mM)
Ethanol 10 mg/mL
(24.72 mM)
Water Insoluble

Chemical Information

Molecular Weight 404.46


CAS No. 1306760-87-1
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC(C)OC1=C(C=C(C=C1)C2=NC(=NO2)C3=C4CCC(C4=CC=C3)NCCO)C#N

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05076175 Not yet recruiting Drug: Ozanimod Colitis Ulcerative Bristol-Myers Squibb October 29 2021 Phase 2|Phase 3
NCT04639115 Recruiting Drug: Ozanimod Liver Diseases|Digestive System Diseases Celgene December 18 2020 Phase 1
NCT04528290 Completed Drug: Ozanimod Healthy Volunteers Celgene October 7 2020 Phase 1
NCT04211558 Completed Drug: Ozanimod Healthy Volunteer Celgene August 12 2020 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Ozanimod (RPC1063) | Ozanimod (RPC1063) supplier | purchase Ozanimod (RPC1063) | Ozanimod (RPC1063) cost | Ozanimod (RPC1063) manufacturer | order Ozanimod (RPC1063) | Ozanimod (RPC1063) distributor