For research use only.
CAS No. 1306760-87-1
Ozanimod (RPC1063) is a selective oral S1P Receptor 1 modulator. Phase 3.
Selleck's Ozanimod (RPC1063) has been cited by 5 publications
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|Description||Ozanimod (RPC1063) is a selective oral S1P Receptor 1 modulator. Phase 3.|
In S1P1R-HEK293T cells, Ozanimod induces sustained S1P1R internalization and degradation. 
|In vivo||In vivo, Ozanimod shows high oral bioavailability and volume of distribution. In a MOG-induced EAE mouse model, Ozanimod (3 mg/kg, p.o.) suppresses clinical symptoms. In a rat TNBS model of inflammatory bowel disease, Ozanimod (1.2 mg/kg, p.o.) inhibits clinical and histological disease scores. In a Naïve CD4+CD45Rbhi T cell adoptive transfer model, Ozanimod (1.2 mg/kg, p.o.) also significantly reduced disease severity as assessed by measuring the degree of inflammation, gland loss, hyperplasia, neutrophil infiltrate and mucosal thickness. |
|In vitro||DMSO||81 mg/mL (200.26 mM)|
|Ethanol||10 mg/mL (24.72 mM)|
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|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
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|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04639115||Recruiting||Drug: Ozanimod||Liver Diseases|Digestive System Diseases||Celgene||December 18 2020||Phase 1|
|NCT04528290||Recruiting||Drug: Ozanimod||Healthy Volunteers||Celgene||October 7 2020||Phase 1|
|NCT04211558||Completed||Drug: Ozanimod||Healthy Volunteer||Celgene||August 12 2020||Phase 1|
|NCT03464097||Recruiting||Drug: Ozanimod|Other: Placebo||Crohn Disease||Celgene||June 27 2018||Phase 3|
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