Orludodstat (BAY 2402234)

Catalog No.S8847

For research use only.

Orludodstat (BAY 2402234) is a novel and selective dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 1.2 nM.

Orludodstat (BAY 2402234) Chemical Structure

CAS No. 2225819-06-5

Selleck's Orludodstat (BAY 2402234) has been cited by 3 Publications

Purity & Quality Control

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Biological Activity

Description Orludodstat (BAY 2402234) is a novel and selective dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 1.2 nM.
Targets
DHODH [1]
(Cell-free assay)
1.2 nM
In vitro

BAY 2402234 induces differentiation and inhibits proliferation in AML cell lines across multiple AML subtypes.[1]

In vivo

BAY 2402234 shows strong monotherapy efficacy and induces differentiation in AML xenograft models in vivo.[1]

Protocol (from reference)

Cell Research:

[1]

  • Cell lines: MOLM-13, HEL, MV4-11, SKM-1 and THP-1 cell lines
  • Concentrations: 0.1nM to 1μM
  • Incubation Time: 96 h
  • Method:

    MOLM-13, HEL, MV4-11, SKM-1 and THP-1 cells were plated in 96-well plates at 20,000 cells per well in their respective growth media and were treated with BAY 2402234 in the presence or absence of 100 μM uridine.

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 520.84
Formula

C21H18ClF5N4O4

CAS No. 2225819-06-5
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCN1C(=NN(C1=O)C2=C(C=C(C(=C2)OC(C)C(F)(F)F)C(=O)NC3=C(C=CC=C3Cl)F)F)CO

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05061251 Withdrawn Drug: BAY 2402234 Glioma|IDH Mutation University of Texas Southwestern Medical Center|Bayer December 1 2021 Early Phase 1

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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