Home Neuronal Signaling AChR inhibitor Otilonium Bromide For research use only.

Otilonium Bromide

Otilonium bromide is an antimuscarinic.

Otilonium Bromide Chemical Structure

Otilonium Bromide Chemical Structure

CAS: 26095-59-0

Selleck's Otilonium Bromide has been cited by 2 publications

Purity & Quality Control

Batch: S304701 DMSO] 113 mg/mL] false] Water] 113 mg/mL] false] Ethanol] 113 mg/mL] false Purity: 99.68%
99.68

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Biological Activity

Description Otilonium bromide is an antimuscarinic.
Targets
mAChR [1]
In vitro
In vitro Otilonium bromide is a quaternary ammonium compound whose spasmolytic action, selective on the distal gastrointestinal tract, is mainly due to its direct myolytic properties. [1] This drug modifies Ca2+ fluxes from extracellular and intracellular pools in the intestinal smooth muscle and is poorly absorbed, thus it exerts its action locally, without any considerable systemic effect. [2]

Chemical Information & Solubility

Molecular Weight 563.57 Formula

C29H43BrN2O4
CAS No. 26095-59-0 SDF Download Otilonium Bromide SDF
Smiles CCCCCCCCOC1=CC=CC=C1C(=O)NC2=CC=C(C=C2)C(=O)OCC[N+](C)(CC)CC.[Br-]
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 113 mg/mL ( (200.5 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 113 mg/mL

Ethanol : 113 mg/mL


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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