Catalog No.S7681

OF-1 Chemical Structure

Molecular Weight(MW): 440.31

OF-1 is a potent inhibitor of BRPF1B and BRPF2 bromodomain with Kd of 100 nM and 500 nM, respectively.

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Biological Activity

Description OF-1 is a potent inhibitor of BRPF1B and BRPF2 bromodomain with Kd of 100 nM and 500 nM, respectively.
BRPF1B [1]
BRPF2 [1]
100 nM(Kd) 500 nM(Kd)
In vitro

As a chemical probe for BRPF bromodomains, OF-1 increases thermal stability in the cellular thermal shift assay of full length BRPF1B at 1 μM and also demonstrates accelerated FRAP recovery at 5 μM in the BRPF2 FRAP assay. In addition, OF-1 shows modest general cytotoxicity. [1]


Solubility (25°C)

In vitro DMSO 76 mg/mL warmed (172.6 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
For best results, use promptly after mixing.

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 440.31


CAS No. 919973-83-4
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03201744 Recruiting Hernia Ventral|Neuromuscular Blockade|Pneumoperitoneum Stony Brook University|Merck Sharp & Dohme Corp. August 29 2017 Not Applicable
NCT03323099 Not yet recruiting Atrial Fibrillation Paroxysmal University of California San Francisco December 2018 Not Applicable
NCT02995083 Withdrawn Symptomatic Osteoarthritis of the Knee Rush University Medical Center June 2017 Early Phase 1
NCT02290886 Recruiting Amyotrophic Lateral Sclerosis Andalusian Initiative for Advanced Therapies - Fundación Pública Andaluza Progreso y Salud|Iniciativa Andaluza en Terapias Avanzadas July 2014 Phase 1|Phase 2
NCT02065973 Unknown status Study to Evaluate the Safety Tolerability and Pharmacodynamics of PDS0101 in Female Subjects With High-risk HPV Infection and Biopsy-proven CIN1. PDS Biotechnology Corp. February 2014 Phase 1
NCT01996111 Terminated Plantar Fasciitis MiMedx Group Inc. September 2013 Not Applicable

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Epigenetic Reader Domain Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID