Name: Oxcarbazepine
Brand: Selleck Chemicals
SKU: S1391
Rating: 5 (1 reviews)

Oxcarbazepine (GP47680) inhibits the binding of [3H]BTX to sodium channels with IC50 of 160 μM and also inhibits the influx of ²²Na⁺ into rat brain synaptosomes with IC50 about 100 μM.

Oxcarbazepine Chemical Structure

CAS: 28721-07-5

Purity & Quality Control

Batch: S139101 DMSO] 7 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.95%

99.95

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Signaling Pathway

Sodium Channel Signaling Pathway

Choose Selective Sodium Channel Inhibitors

Biological Activity

Description

Oxcarbazepine (GP47680) inhibits the binding of [3H]BTX to sodium channels with IC50 of 160 μM and also inhibits the influx of ²²Na⁺ into rat brain synaptosomes with IC50 about 100 μM.

Targets

sodium channel ^[1]

160 μM

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT02104661	Completed	Multiple Sclerosis	Queen Mary University of London\|National Multiple Sclerosis Society\|Novartis Pharmaceuticals\|Barts & The London NHS Trust\|University College London\|Royal Free Hospital NHS Foundation Trust\|Mid and South Essex NHS Foundation Trust\|St George''s Healthcare NHS Trust\|Barnet and Chase Farm Hospitals NHS Trust	October 2014	Phase 2
NCT02098941	Unknown status	Epilepsy	Seoul National University Hospital\|Janssen Korea Ltd. Korea	March 2014	--
NCT02362373	Completed	Epilepsy\|Contraception	Columbia University\|Bayer	August 2011	Phase 4
NCT00951847	Completed	Healthy	Ranbaxy Laboratories Limited\|Ranbaxy Inc.	October 2006	Not Applicable
NCT00951600	Completed	Healthy	Ranbaxy Laboratories Limited\|Ranbaxy Inc.	September 2006	Not Applicable

Chemical Information & Solubility

Molecular Weight	252.27	Formula	C₁₅H₁₂N₂O₂
CAS No.	28721-07-5	SDF	Download Oxcarbazepine SDF
Smiles	C1C2=CC=CC=C2N(C3=CC=CC=C3C1=O)C(=O)N
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 7 mg/mL ( (27.74 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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