Oxcarbazepine

Catalog No.S1391 Synonyms: GP47680

For research use only.

Oxcarbazepine (GP47680) inhibits the binding of [3H]BTX to sodium channels with IC50 of 160 μM and also inhibits the influx of 22Na+ into rat brain synaptosomes with IC50 about 100 μM.

Oxcarbazepine Chemical Structure

CAS No. 28721-07-5

Purity & Quality Control

Choose Selective Sodium Channel Inhibitors

Other Sodium Channel Products

Biological Activity

Description Oxcarbazepine (GP47680) inhibits the binding of [3H]BTX to sodium channels with IC50 of 160 μM and also inhibits the influx of 22Na+ into rat brain synaptosomes with IC50 about 100 μM.
Targets
sodium channel [1]
160 μM

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 7 mg/mL
(27.74 mM)
Water Insoluble
Ethanol Insoluble

Chemical Information

Molecular Weight 252.27
Formula

C15H12N2O2

CAS No. 28721-07-5
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1C2=CC=CC=C2N(C3=CC=CC=C3C1=O)C(=O)N

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02104661 Completed Drug: Oxcarbazepine|Drug: Placebo Multiple Sclerosis Queen Mary University of London|National Multiple Sclerosis Society|Novartis Pharmaceuticals|Barts & The London NHS Trust|University College London|Royal Free Hospital NHS Foundation Trust|Mid and South Essex NHS Foundation Trust|St George''s Healthcare NHS Trust|Barnet and Chase Farm Hospitals NHS Trust October 2014 Phase 2
NCT02098941 Unknown status -- Epilepsy Seoul National University Hospital|Janssen Korea Ltd. Korea March 2014 --
NCT02362373 Completed Drug: levonorgestrel IUS Epilepsy|Contraception Columbia University|Bayer August 2011 Phase 4
NCT00951847 Completed Drug: oxcarbazepine 300 mg/5 mL oral suspension Healthy Ranbaxy Laboratories Limited|Ranbaxy Inc. October 2006 Not Applicable
NCT00951600 Completed Drug: oxcarbazepine 300 mg/5mL oral suspension Healthy Ranbaxy Laboratories Limited|Ranbaxy Inc. September 2006 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Oxcarbazepine | Oxcarbazepine supplier | purchase Oxcarbazepine | Oxcarbazepine cost | Oxcarbazepine manufacturer | order Oxcarbazepine | Oxcarbazepine distributor