Natural Products

Long before the era of high-throughput screening and genomics, drug discovery relied heavily on natural compounds. In fact, many of the drugs available today contain active ingredients extracted from natural products. Since 1994, nearly half of all drugs were discovered using natural products. Furthermore, between 2005 and 2007, there were 13 new drugs based on natural products that entered the commercial market, including the following 5 new products: small molecule ixabepilone, retapamulin, trabectedin, and the peptides exenatide and ziconotide. Clearly, natural product drug discovery programs continue to play a significant role in the clinical development of new therapies in the biopharmaceutical industry.

As a leading supplier of products and services for scientific research, we provide a wide range of natural products. At Selleckchem.com our goal is to provide our customers with the most comprehensive, highest quality, and competitively priced natural products on the web. Our portfolio covers natural chemistry products originating from a variety of plants, marine, and microbiological sources.

Natural Product Library
Product Categories
Alkaloids
Anthraquinones
Flavones
Phenols
Phenylpropanoids
Quinones
Steroids
Terpenoids
Xanthones
Others

Alkaloids

water-soluble

Cat.No. Product Name Information
S3068 Guanosine Hydrate Guanosine hydrate plays important roles in various biochemical processes such as synthesis of nucleic acids and proteins, photosynthesis, muscle contraction and intracellular signal transduction (cGMP).
S2253 3-Indolebutyric acid (IBA) 3-Indolebutyric acid(IBA) is a plant hormone in the auxin family and is an ingredient in many commercial plant rooting horticultural products.
S2424 Hypoxanthine Hypoxanthine is a naturally occurring purine derivative.
S2442 Inosine Inosine is a nucleoside that is formed when hypoxanthine is attached to a ribose ring via a β-N9-glycosidic bond.
S2382 Evodiamine Evodiamine (Isoevodiamine), an alkaloid extract from the fruit of Evodiae Fructus exhibits antitumor activities against the human tumor cells.
S2386 Indirubin Indirubin is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 5 μM and 0.6 μM.
S2267 Azomycin Azomycin is an antimicrobial antibiotic produced by a strain of Nocardia mesenterica.
S2387 Lappaconite HBr Lappaconite Hydrobromide is a kind of alkaloid extracted from Aconitum sinomontanum Nakai and has anti-inflammatory effects.
S2271 Berberine HCl Berberine HCl is a quaternary ammonium salt from the group of isoquinoline alkaloids.
S2282 Cinchonidine Cinchonidine is an alkaloid used in asymmetric synthesis in organic chemistry.
S2423 (S)-10-Hydroxycamptothecin 10-Hydroxycamptothecin is a DNA topoisomerase I inhibitor with potent anti-tumor activity.
S2437 Rotundine Rotundine (L-tetrahydropalmatine, L-THP) is a selective dopamine D1 receptor antagonist with IC50 of 166 nM.
S2287 Cytisine Cytisine is a nicotinic acetylcholine receptor agonist.
S2385 Hordenine Hordenine (N,N-dimethyl-4-hydroxyphenylethylamine) is a phenylethylamine alkaloid with antibacterial and antibiotic properties.
S1973 Cyclocytidine HCl Cyclocytidine is the prodrug of cytarabine, which is a pyrimidine nucleoside analog that inhibits the DNA synthesis and used mainly in the treatment of leukemia.
S2397 Palmatine chloride Palmatine hydrochloride (Palmatine chloride (6CI,7CI); Fibrauretin) is a hydrochloride salt of palmatine which is a protoberberine alkaloid.
S2402 Cyclovirobuxin D Cyclovirobuxine D is an active compound extracted from Buxus microphylla, which has been used for treating acute myocardial ischemia.
S2304 Gramine Gramine is a naturally occurring indole alkaloid present in several plant species.
S2403 Tetrandrine Tetrandrine, a bis-benzylisoquinoline alkaloid derived from Stephania tetrandra, is a calcium channel blocker.
S2405 Sophocarpine Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
S2313 Indole-3-carbinol Indole-3-carbinol is produced by the breakdown of the glucosinolate glucobrassicin, which can be found at relatively high levels in cruciferous vegetables.
S2316 Kinetin Kinetin is a type of cytokinin, a class of plant hormone that promotes cell division.
S2322 (+)-Matrine Matrine((+)-Matrine) is an alkaloid found in plants from the Sophora family, which has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor agonist.
S2439 Guanosine Guanosine is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond.
S2336 Orotic acid (6-Carboxyuracil) Orotic acid(6-Carboxyuracil) is a heterocyclic compound and an acid.
S2338 Oxymatrine Oxymatrine is a quinolizidine alkaloid extracted from the root of Sophora flavescens, which is used for the treatment of viral hepatitis, cancer, viral myocarditis, gastrointestinal hemorrhage and skin diseases.
S2344 Piperine Piperine (1-Piperoylpiperidine) is the alkaloid responsible for the pungency of black pepper and long pepper, which has also been used in some forms of traditional medicine and as an insecticide.
S2349 Rutaecarpine Rutaecarpine is an indolopyridoquinazolinone alkaloid isolated from Evodia rutaecarpa and related herbs.
S3190 N6-methyladenosine (m6A) N6-methyl adenosine (N6-methyl ATP) is a base modified analog of adenosine and is found as a minor nucleoside in natural RNAs.
S2359 Sinomenine Sinomenine, a pure alkaloid extracted from the chinese medical plant Sinomenium acutum, is used for the treatment of rheumatism and arthritis.
S2367 Tetrahydropapaverine HCl Tetrahydropapaverine, one of the TIQs and an analogue of salsolinol and tetrahydropapaveroline, has been reported to have neurotoxic effects on dopamine neurons.
S2368 Theobromine Theobromine is a xanthine alkaloid widely consumed as stimulants and snacks in coffee and cocoa based foods and most often as part of ingredients in drugs.
S2373 Yohimbine HCl Yohimbine has been used as a mydriatic and in the treatment of impotence. It is also alleged to be an aphrodisiac.

Anthraquinones

water-soluble

Cat.No. Product Name Information
S4033 Sennoside A Sennoside A, a kind of irritant laxative isolated from rhei rhizome, causes purgative actions in the intestine.
S4018 Sennoside B Sennoside B, a kind of irritant laxative isolated from rhei rhizome, inhibits PDGF-stimulated cell proliferation.
S2375 Aloin Aloin, a natural anthracycline from Aloe vera, is a tyrosinase inhibitor.
S2259 Aloe-emodin Aloe-emodin is an interferon-inducing agent with IC50 of about 1 μg/mL for JEV and of about 0.33 μg/mL for EV71.
S2295 Emodin Emodin is a purgative resin, 6-methyl-1,3,8-trihydroxyanthraquinone, from rhubarb, the buckthorn and Japanese Knotweed (Fallopia japonica).
S2395 Rheochrysidin Physcion is a anthraquinone from roots of Rheum officinale Baill.
S2400 Rheic Acid Rhein (Monorhein; NSC 38629; Rheic acid; Rheinic acid) is an anthraquinone compound enriched in the fresh rhizome of Rheum coreanum Nakai, showing anti-inflammation and antitumor activities.
S2406 Chrysophanic Acid Chrysophanic acid (Chrysophanol), a natural anthraquinone isolated from Dianella longifolia, is a EGFR/mTOR pathway inhibitor.

Flavones

water-soluble

Cat.No. Product Name Information
S8036 Butein Butein, a plant polyphenol isolated from Rhus verniciflua, is able to inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, also inhibits EGFR
S2377 Biochanin A Biochanin A, an O-methylated isoflavone from Trifolium pratense, inhibits protein tyrosine kinase (PTK) of epidermal growth factor receptor with IC50 values of 91.5 μM.
S2380 Diosmetin Diosmetin is a bioflavonoid found in spearmint, oregano, and many other plants.
S2262 Apigenin Apigenin is a potent P450 inhibitor for CYP2C9 with IC50 of 23 pM.
S2268 Baicalein Baicalein is a CYP2C9 and prolyl endopeptidase inhibitor.
S2269 Baicalin Baicalin is a known prolyl endopeptidase inhibitor and affects the GABA receptors.
S2389 Naringin Dihydrochalcone Naringin Dihydrochalcone(Naringin DC) is a new-style sweetening agent and an artificial sweetener derived from naringin.
S2270 Bergenin Bergenin is trihydroxybenzoic acid glycoside and the C-glycoside of 4-O-methyl gallic acid.
S2391 Quercetin Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM.
S2281 Chrysin Chrysin is a naturally occurring flavone chemically extracted from the blue passion flower (Passiflora caerulea).
S2422 Ipriflavone (Osteofix) Ipriflavone (7-Isopropoxyisoflavon) is used to inhibit bone resorption.
S2289 Daidzin Daidzin is a natural organic compound in the class of phytochemicals known as isoflavones.
S2394 Naringenin Naringenin is a natural predominant flavanone derived from plant food, which is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator.
S2292 Diosmin Diosmin is a semisynthetic phlebotropic agent and a member of the flavonoid family.
S2298 Fisetin Fisetin (Fustel) is a potent sirtuin activating compound (STAC) and an agent that modulates sirtuins.
S2299 Formononetin Formononetin is a phytoestrogen from the root of Astragalus membranaceus and an O-methylated isoflavone.
S2399 Dihydromyricetin Dihydromyricetin (Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata.
S2308 Hesperetin Hesperetin is a bioflavonoid and, to be more specific, a flavanone.
S2309 Hesperidin Hesperidin is a flavanone glycoside found abundantly in citrus fruits.
S2404 Isoliquiritigenin Isoliquiritigenin, an anti-tumor flavonoid from the root of Glycyrrhiza glabra, inhibits aldose reductase with an IC50 of 320 nM.
S2312 Icariin Icariin is a cGMP-specific PDE5 inhibitor with IC50 of 0.432 μM, 167-fold more selective for PDE5 than PDE4.
S2314 Kaempferol Kaempferol is a natural flavonol, a type of flavonoid, that has been isolated from plant sources.
S2320 Luteolin Luteolin is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively.
S2332 Neohesperidin Neohesperidin, a flavanone glycoside found in citrus fruits, is an antioxidant agent.
S2323 Methyl-Hesperidin Methyl Hesperidin is a flavanone glycoside (flavonoid) (C28H34O15) found abundantly in citrus fruits. Its aglycone form is called hesperetin.
S2325 Morin Hydrate Morin hydrate(Aurantica) is a flavonoid isolated from Maclura pomifera (Osage orange), Maclura tinctoria (old fustic) and from leaves of Psidium guajava (common guava).
S2326 Myricetin Myricetin is a flavonoid found in many grapes, berries, fruits, vegetables, herbs, as well as other plants, which has antioxidant and anti tumor properties.
S2327 Myricitrin Myricitrin, a flavonoid compound isolated from the root bark of Myrica cerifera, which exerts antinociceptive effects.
S2329 Naringin Naringin is a flavanone glycoside, which exerts a variety of pharmacological effects such as antioxidant activity, blood lipid lowering, anticancer activity, and inhibition of cytochrome P450 enzymes.
S2331 Neohesperidin Dihydrochalcone (Nhdc) Neohesperidin dihydrochalcone(Nhdc), sometimes abbreviated to neohesperidin DC or simply NHDC, is an artificial sweetener derived from citru
S2333 Nobiletin Nobiletin, a citrus flavonoid isolated from citrus peels like in tangerine, which has anti-inflammatory and anti-tumor activities.
S2342 Phloretin Phloretin is a dihydrochalcone found in apple tree leaves, which shows beneficial effects on diabetes.
S2343 Phlorizin Phlorizin is a dihydrochalcone found in the bark of pear (Pyrus communis), apple, cherry and other fruit trees.
S2346 Puerarin Puerarin (Kakonein), an isoflavones found in the root of Radix puerariae, is a 5-HT2C receptor and benzodiazepine site antagonist.
S2347 Quercetin Dihydrate Quercetin, a polyphenolic flavonoid found in a wide variety of plant-based foods, such as apples, onions, berries, and red wine, is utilized in many different cultures for their nervous system and anticancer effects.
S2350 Rutin Rutin, a flavonol glycoside found in many plants including buckwheat; tobacco; forsythia; hydrangea; viola, etc., which possesses healthy effects for human.
S2357 Silibinin Silibinin, the main flavonoid extracted from the milk thistle Silybum marianum, displays hepatoprotective properties in acute and chronic liver injury.
S2358 Silymarin Silymarin (Silybin B), a polyphenolic flavonoid extracted from the seeds of Silybum marianum or milk thistle, is used in the prevention and treatment of liver diseases and primary liver cancer.
S2363 Tangeretin Tangeretin, a natural polymethoxylated flavone concentrated in the peel of citrus fruits, is known to have antiproliferative, antiinvasive, antimetastatic and antioxidant activities.
S2366 Taxifolin (Dihydroquercetin) Taxifolin is a flavonoid in many plants such as Taxus chinensis, Siberian larch, Cedrus deodara and so on.
S2369 Troxerutin Troxerutin, a natural bioflavonoid isolated from Sophora japonica., has been reported to have many benefits and medicinal properties.

Phenols

water-soluble

Cat.No. Product Name Information
S2250 (-)-Epigallocatechin Gallate (-)-Epigallocatechin Gallate is the main catechin extraction of green tea, which shows multiple bioactivity.
S3071 Vanillin Vanillin, 4-hydroxy-3-methoxybenzaldehyde, is a food additive.
S2263 Arbutin Arbutin is a tyrosinase inhibitor with an IC50 of 1.09 mM.
S2383 Gastrodin Gastrodin, an anti-inflammatory polyphenol extracted from Chinese natural herbal Gastrodia elata Blume., benefits neurodegenerative diseases.
S2390 Polydatin Polydatin is a crystal component extracted from the root stem of perennial herbage Polygonum Cuspidatum Sieb.et Zucc.
S2425 Apocynin Apocynin is a selective NADPH-oxidase inhibitor with IC50 of 10 μM.
S2396 Salidroside Salidroside, a phenylpropanoid glycoside isolated from Rhodiola rosea, has been reported to have a broad spectrum of pharmacological properties.
S2303 Gossypol Gossypol is a polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
S2339 Paeonol Paeonol (Peonol), a phenolic compound extracted from Chinese herbs Paeonia suffruticosa (moutan cortex) and Cynanchum paniculatum, inhibits MAO with an IC50 of about 50 μM.
S2351 Salicin Salicin is a phenol β-glycosid produced from willow bark that shows anti-inflammatory effects.
S2356 Shikimic Acid Shikimic acid(Shikimate), more commonly known as its anionic form shikimate, is an important biochemical intermediate in plants and microorganisms.
S2362 Synephrine Synephrine, a natural protoalkaloid in the extract of bitter orange and other citrus species, is commonly used for weight loss.
S2371 Vanillylacetone Vanillylacetone is similar in chemical structure to other flavor chemicals such as vanillin and eugenol and is used as a flavor additive in spice oils and in perfumery to introduce spicy aromas.

Phenylpropanoids

water-soluble

Cat.No. Product Name Information
S2256 4-Methylumbelliferone (4-MU) 4-Methylumbelliferone is a hyaluronic acid (HA) synthesis inhibitor with an IC50 of 0.4 mM.
S2258 Esculin Esculin is a glucoside found in horse chestnuts.
S2384 Hematoxylin Hematoxylin (Hydroxybrazilin) is a compound that forms strongly colored complexes with certain metal ions, notably Fe(III) and Al(III) salts and a kind of stain in histology.
S3600 Schisandrin B (Sch B) Schisandrin B is the most abundant dibenzocyclooctadiene lignan present in the traditional Chinese medicinal herb Schisandra chinensis (Turcz.) Baill.
S2392 Sesamin Sesamin, a lignan isolated from the bark of Fagara plants and from sesame oil, exhibits various health benefits.
S2277 Caffeic Acid Caffeic acid is a hydroxycinnamic acid, a naturally occurring organic compound.
S2280 Chlorogenic Acid Chlorogenic acid is a hydroxycinnamic acid and a member of a family of naturally occurring organic compounds.
S2300 Ferulic Acid Ferulic Acid is a hydroxycinnamic acid and a type of organic compound found in the Ferula assafoetida L. or Ligusticum chuanxiong.
S2401 Sodium Danshensu Sodium Danshensu is a mono sodium of danshensu, which is a natural phenolic acid of caffeic acid derivatives isolated from Salvia miltiorrhiza.
S2321 Magnolol Magnolol is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties.
S2337 Osthole Osthol is an O-methylated coumarin, which is found in the plants such as Cnidium monnieri, Angelica archangelica and Angelica pubescens.
S2341 (-)-Parthenolide (-)-Parthenolide is a sesquiterpene lactone which occurs naturally in the plant feverfew(Tanacetum parthenium) and also promotes the ubiquitination of MDM2 and activates p53 cellular functions.

Quinones

water-soluble

Cat.No. Product Name Information
S7025 Embelin Embelin, a quinone isolated from the Japanese Ardisia herb, is an inhibitor of X-linked inhibitor of apoptosis (XIAP) with IC50 of 4.1 μM.
S2252 (+)-Usniacin (+)-Usniacin is a naturally occurring dibenzofuran derivative found in several lichen species.
S2285 Cryptotanshinone Cryptotanshinone (CPT) is a STAT3 inhibitor with IC50 of 4.6 μM, strongly inhibits phosphorylation of STAT3 Tyr705, with a small effect on STAT3 Ser727, but none against STAT1 nor STAT5.
S2364 Tanshinone I Tanshinone I, an active principle isolated from Salvia miltiorrhiza (Danshen), is structurally similar to tanshinone IIA and may possess similar cytotoxic effects on tumor cells.
S2365 Tanshinone IIA Tanshinone IIA(Tanshinone B) is the most abundant diterpene quinone in Danshen, Salviae miltiorrhizae Radix, a widely prescribed traditional herbal medicine that is used to treat cardiovascular and inflammatory diseases.

Steroids

water-soluble

Cat.No. Product Name Information
S2273 β-Sitosterol β-Sitosterol is one of several phytosterols (plant sterols) with chemical structures similar to that of cholesterol.
S2291 Diosgenin Diosgenin is a steroid sapogenin and the precursor for the semisynthesis of progesterone which in turn was used in early combined oral contraceptive pills.
S2297 Ergosterol Ergosterol is a sterol and a biological precursor (a provitamin) to vitamin D2.
S2311 Hyodeoxycholic acid (HDCA) Hyodeoxycholic(HDCA) acid is a secondary bile acid, one of the metabolic byproducts of intestinal bacteria.
S2361 Stigmasterol Stigmasterol is an unsaturated plant sterol, which may be useful in prevention of certain cancers.

Terpenoids

water-soluble

Cat.No. Product Name Information
S2379 Dioscin Dioscin is a saponin extracted and isolated from Polygonatum Zanlanscianense Pamp, showing antitumor activities.
S2261 Andrographolide Andrographolide is a labdane diterpenoid that is the main bioactive component of the medicinal plant Andrographis paniculata.
S2265 Artesunate Artesunate is a part of the artemisinin group of agents with an IC50 of < 5 μM for small cell lung carcinoma cell line H69.
S2266 Asiatic Acid Asiatic acid is the aglycone of asiaticoside isolated from the plant Centella asiatica, commonly used in wound healing.
S2276 Bilobalide Bilobalide is a biologically active terpenic trilactone present in Ginkgo biloba.
S2290 Dihydroartemisinin (DHA) Dihydroartemisinin (DHA) is a semi-synthetic derivative of artemisinin and isolated from the traditional Chinese herb Artemisia annua.
S2296 Enoxolone Enoxolone is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrhizic acid, which was obtained from the herb liquorice.
S2302 Glycyrrhizic Acid Glycyrrhizic acid is a widely used anti-inflammatory agent isolated from the licorice root.
S2306 Gynostemma Extract Gynostemma Extract is a saponins extract derived from the Gynostemma pentaphyllum.
S2407 Curcumol Curcumol is a pure monomer isolated from Rhizoma Curcumaeis with antitumor activities.
S2319 Limonin Limonin is a triterpenoid enriched in citrus fruits, which has antivirus and antitumor ability.
S2415 Astragaloside A Astragaloside A (Astragaloside IV) is the primary pure saponin isolated from Astragalus membranaceus, which has been widely used for the treatment of cardiovascular diseases.
S2334 Oleanolic Acid Oleanolic Acid is a non-toxic, hepatoprotective triterpenoid found in Phytolacca Americana, which exerts antitumor and antiviral properties.
S2335 Oridonin Oridonin, a diterpenoid purified from Rabdosia rubescens, is an antitumor agent.
S3603 Betulinic acid Betulinic acid, a pentacyclic triterpenoid from Syzigium claviflorum, is a inhibitor of HIV-1 with EC50 of 1.4 μ M. Phase 1/2.
S3604 Triptolide (PG490) Triptolide is a diterpene triepoxide, immunosuppresive agent extracted from the Chinese herb Tripterygium wilfordii.
S2354 Sclareol Sclareol, a labdane-type diterpene isolated from clary sage (Salvia sclarea), exerts growth inhibition and cytotoxic activity against a variety of human cancer cell lines.
S2355 Sclareolide Sclareolide(Norambreinolide) is a sesquiterpene lactone natural product derived from various plant sources including Salvia sclarea, Salvia yosgadensis, and cigar tobacco.
S2370 Ursolic Acid Ursolic acid (Malol) is a pentacyclic triterpene acid, used in cosmetics.

Xanthones

water-soluble

Cat.No. Product Name Information
S2448 Gambogic Acid Gambogic Acid activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μM, respectively.
S2372 Xanthone Xanthone is an organic compound, which can be prepared by the heating of phenyl salicylate.

Others

water-soluble

Cat.No. Product Name Information
S2374 5-hydroxytryptophan (5-HTP) 5-Hydroxytryptophan (5-HTP), also known as oxitriptan (INN), is a naturally occurring amino acid and chemical precursor for the treatment of depression.
S2260 Laetrile Laetrile is a glycoside initially isolated from the seeds of the tree Prunus dulcis, also known as bitter almonds.
S2398 Coenzyme Q10 (CoQ10) Coenzyme Q10 (ubiquinone, ubidecarenone, coenzyme Q) is a component of the electron transport chain and participates in aerobic cellular respiration.
S2317 L-(+)-Rhamnose Monohydrate L(+)-Rhamnose (Rham) is a naturally-occurring deoxy sugar that is found primarily in plants and some bacteria.
S2324 Sodium Monensin Sodium Monensin, isolated from Streptomyces cinnamonensis, is a well-known representative of naturally polyether ionophore antibiotics.
S2352 Salinomycin Salinomycin is an antibacterial and coccidiostat ionophore therapeutic drug.
S2353 Sapogenins Glycosides Sapogenins glycosides are a mixture of triterpene and steroid saponins isolated from medicinal plants such as Aesculus hippocastanum L., Hedera helix L. and Ruscus aculeatus L., which are claimed to be effective for the treatment/prevention of venous insu