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Long before the era of high-throughput screening and genomics, drug discovery relied heavily on natural compounds. In fact, many of the drugs available today contain active ingredients extracted from natural products. Since 1994, nearly half of all drugs were discovered using natural products. Furthermore, between 2005 and 2007, there were 13 new drugs based on natural products that entered the commercial market, including the following 5 new products: small molecule ixabepilone, retapamulin, trabectedin, and the peptides exenatide and ziconotide. Clearly, natural product drug discovery programs continue to play a significant role in the clinical development of new therapies in the biopharmaceutical industry.

As a leading supplier of products and services for scientific research, we provide a wide range of natural products. At Selleckchem.com our goal is to provide our customers with the most comprehensive, highest quality, and competitively priced natural products on the web. Our portfolio covers natural chemistry products originating from a variety of plants, marine, and microbiological sources.

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water-soluble

Cat.No. Product Name Information
S4033 Sennoside A Sennoside A is a laxative agent derived from the leaves⁄pods of Cassia acutifolia and C. angustifolia and known to decompose on heating during decoction.
S4018 Sennoside B Sennoside B is a laxative agent derived from the leaves⁄pods of Cassia acutifolia and C. angustifolia and found to selectively inhibit PDGF-BB-induced PDGFR phosphorylation with IC50 of 19.2 nM in osteosarcoma cells.
S3190 N6-methyladenosine N6-methyl adenosine (N6-methyl ATP) is a base modified analog of adenosine and is found as a minor nucleoside in natural RNAs.
S2448 Gambogic Acid Gambogic Acid activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-xl, Bcl-2, Bcl-w, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM, respectively.
S2425 Apocynin (Acetovanillone) Apocynin (Acetovanillone) is a selective NADPH-oxidase inhibitor with IC50 of 10 μM.
S3600 Schisandrin B Schisandrin B is the most abundant dibenzocyclooctadiene lignan present in the traditional Chinese medicinal herb Schisandra chinensis (Turcz.) Baill.
S3068 Guanosine Hydrate Guanosine hydrate plays important roles in various biochemical processes such as synthesis of nucleic acids and proteins, photosynthesis, muscle contraction and intracellular signal transduction (cGMP).
S2424 Hypoxanthine Hypoxanthine is a naturally occurring purine derivative.
S2442 Inosine Inosine is a nucleoside that is formed when hypoxanthine is attached to a ribose ring via a β-N9-glycosidic bond.
S1973 Cyclocytidine HCl
S2422 Ipriflavone Ipriflavone (7-Isopropoxyisoflavon) is used to inhibit bone resorption.
S2423 10-Hydroxycamptothecin 10-Hydroxycamptothecin (10-HCPT, 10-hydroxy-CPT, OHCPT, NSC107124) is a DNA topoisomerase I inhibitor with potent anti-tumor activity.
S2437 Rotundine Rotundine (L-tetrahydropalmatine, L-THP) is a selective dopamine D1 receptor antagonist with IC50 of 166 nM.
S3603 Betulinic acid Betulinic acid is a naturally occurring pentacyclic triterpenoid which has antiretroviral, antimalarial, and anti-inflammatory properties.
S3604 Triptolide Triptolide is a diterpene triepoxide, immunosuppresive agent extracted from the Chinese herb Tripterygium wilfordii.
S2439 Guanosine
S3071 Vanillin Vanillin, 4-hydroxy-3-methoxybenzaldehyde, is a food additive.
S2415 Astragaloside A Astragaloside A is a pure small molecular compound isolated from Radix Astragali and is commonly used in the treatment of degenerative bone diseases such as osteoporosis.
S2394 Naringenin Naringenin is a flavonoid that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator.
S2332 Neohesperidin Neohesperidin is an antioxidant agent with an IC50 of 22.31 μg/ml in the 1,1-diphenyl-2-picryldydrazyl (DPPH) radical-scavenging assay.
S2404 Isoliquiritigenin Isoliquiritigenin (GU 17) is a strong nod gene- and glyceollin resistance-inducing flavonoid from soybean root exudate.
S2405 Sophocarpine Sophocarpine is a human ether-à-go-go-related gene (HERG) inhibitor with an IC(50) of about 0.2 mM.
S2406 Chrysophanic acid (Chrysophanol) Chrysophanic acid (Chrysophanol) is a EGFR/mTOR pathway inhibitor.
S2407 Curcumol Curcumol is a common traditional Chinese medicine with antitumor activities.
S2400 Rhein(Monorhein) Rhein(Monorhein; NSC 38629; Rheic acid; Rheinic acid) is a constituent of rhubarb which was isolated from the fresh rhizome of Rheum coreanum Nakai.
S2401 Sodium Danshensu Sodium Danshensu is a mono sodium of danshensu which is a compound isolated from Salvia miltiorrhiza Bge.
S2402 Cyclovirobuxin D(Bebuxine) Cyclovirobuxine D (bebuxine; Cyclovirobuxine) is an active compound extracted from Buxus microphylla, which has been used for treating acute myocardial ischemia.
S2403 Tetrandrine(Fanchinine) Tetrandrine (Fanchinine; Hanfangchin A) is a calcium channel blocker with an IC50 of 38.23± 25.77 μM.
S2395 Rheochrysidin (Physcione) Rheochrysidin (Physcion; physcione; parietin) is one of the major components of Da-Cheng-Qi decoction used in the treatment of inflammation.
S2396 Salidroside(Rhodioloside) Salidroside (Rhodioloside; Rhodosin) is a glucoside compound with an IC50 of 4.99 ± 0.23 μg/mL for the proliferation of SACC-2 cells.
S2397 Palmatine chloride Palmatine hydrochloride (Palmatine chloride (6CI,7CI); Fibrauretin) is a hydrochloride salt of palmatine which is a protoberberine alkaloid.
S2398 Coenzyme Q10 (CoQ10) Coenzyme Q10 (ubiquinone, ubidecarenone, coenzyme Q) is a component of the electron transport chain and participates in aerobic cellular respiration.
S2399 Dihydromyricetin(Ampeloptin) Dihydromyricetin (Ampelopsin, flavanol, Ampeloptin) is a natural antioxidant with good prospects.
S2385 Hordenine Hordenine (N,N-dimethyl-4-hydroxyphenylethylamine) is a phenylethylamine alkaloid with antibacterial and antibiotic properties.
S2382 Evodiamine (Isoevodiamine) Evodiamine (Isoevodiamine) is an alkaloid extract from a plant known as Evodiae Fructus.
S2383 Gastrodin (Gastrodine) Gastrodin (Gastrodine) is a polyphenol. It is the glucoside of 4-hydroxybenzyl alcohol (gastrodigenin).
S2384 Hematoxylin (Hydroxybrazilin) Hematoxylin (Hydroxybrazilin) is a compound that forms strongly colored complexes with certain metal ions, notably Fe(III) and Al(III) salts and a kind of stain in histology.
S2386 Indirubin Indirubin is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 75 nM and 0.19 μM.
S2387 Lappaconite HBr Lappaconite Hydrobromide is a kind of alkaloid extracted from Aconitum sinomontanum Nakai and has anti-inflammatory effects.
S2389 Naringin Dihydrochalcone(Naringin DC) Naringin Dihydrochalcone(Naringin DC) is a new-style sweetening agent and an artificial sweetener derived from naringin.
S2390 Polydatin(Piceid) Polydatin(Piceid), 3,4’,5-trihydroxystilbene-3-β-mono-D-glucoside, the crystal component extracted from the root stem of perennial herbage Polygonum Cuspidatum Sieb.et Zucc.
S2391 Quercetin (Sophoretin) Quercetin (Sophoretin) is a PI3K and PKC inhibitor with IC50 of 3.8 μM and 15µg/ml.
S2392 Sesamin(Fagarol) Sesamin(Fagarol) is a lignan isolated from the bark of Fagara plants and from sesame oil.
S2374 5-hydroxytryptophan (5-HTP) 5-Hydroxytryptophan(5-HTP) is decarboxylated to serotonin (5-hydroxytryptamine or 5-HT) by the enzyme aromatic-L-amino-acid decarboxylase with the help of Vitamin B6.
S2375 Aloin (Barbaloin) Aloin(Barbaloin) is a potent tyrosinase inhibitor with an IC50 of 97 μM for HeLaS3 cells
S2377 Biochanin A (4-Methylgenistein) Biochanin A(4-Methylgenistein) is an O-methylated isoflavone. It is a natural organic compound in the class of phytochemicals known as flavonoids.
S2379 Dioscin (Collettiside III) Dioscin(Collettiside III) is a saponin extracted and isolated from Polygonatum Zanlanscianense Pamp with IC50 of 2.6, 0.8, 7.5, and 4.5 μM for the inhibition of the growth of the MDA-MB-435, H14, HL60, and HeLa cell lines, respectively.
S2380 Diosmetin(Luteolin 4-methyl ether) Diosmetin (Luteolin 4-methyl ether) is a bioflavonoid found in spearmint, oregano, and many other plants.
S2371 Vanillylacetone Vanillylacetone is similar in chemical structure to other flavor chemicals such as vanillin and eugenol. It is used as a flavor additive in spice oils and in perfumery to introduce spicy aromas.
S2372 Xanthone (Genicide) Xanthone is an organic compound. It can be prepared by the heating of phenyl salicylate.
S2373 Yohimbine HCl (Antagonil) Yohimbine(Antagonil) has been used as a mydriatic and in the treatment of impotence. It is also alleged to be an aphrodisiac.
S2352 Salinomycin (Procoxacin) Aminoglutethimide (Cytadren) is an anti-steroid drug which inhibits aromatase.
S2353 Sapogenins glycosides Sapogenins are the aglycones, or non-saccharide, portions of the family of natural products known as saponins.
S2354 Sclareol Sclareol is a fragrant chemical compound found in clary sage (Salvia sclarea), from which it derives its name. It is classified as a bicyclic diterpene alcohol.
S2355 Sclareolide (Norambreinolide) Sclareolide(Norambreinolide) is a sesquiterpene lactone natural product derived from various plant sources including Salvia sclarea, Salvia yosgadensis, and cigar tobacco.
S2356 Shikimic acid (Shikimate) Shikimic acid(Shikimate), more commonly known as its anionic form shikimate, is an important biochemical intermediate in plants and microorganisms.
S2357 Silibinin (Silybin) Silibinin(Silybin) is the major active constituent of silymarin.
S2358 Silymarin (Silybin B) Silymarin(Silybin B), a strong novel free radical scavenger, is used for treatment of patients with acute brain infarction.
S2359 Sinomenine (Cucoline) Sinomenine(Cucoline) is traditionally used in herbal medicine in these countries, as a treatment for rheumatism and arthritis.
S2361 Stigmasterol (Stigmasterin) Stigmasterol(Stigmasterin) is used as a precursor in the manufacture of synthetic progesterone.
S2362 Synephrine (Oxedrine) Synephrine (Oxedrine) is a compound commonly used for weight loss.
S2363 Tangeretin (Tangeritin) Tangeretin(Tangeritin) is a citrus flavonoids.
S2364 Tanshinone I Tanshinone I is isolated from Danshen.
S2365 Tanshinone IIA (Tanshinone B) Tanshinone IIA(Tanshinone B) is the most abundant diterpene quinone in Danshen, Salviae miltiorrhizae Radix, a widely prescribed traditional herbal medicine that is used to treat cardiovascular and inflammatory diseases.
S2366 Taxifolin (Dihydroquercetin) Taxifolin(Dihydroquercetin) is a flavanonol, a type of flavonoid.
S2367 Tetrahydropapaverine HCl Tetrahydropapaverine, one of the TIQs and an analogue of salsolinol and tetrahydropapaveroline, has been reported to have neurotoxic effects on dopamine neurons.
S2368 Theobromine (3,7-Dimethylxanthine) Theobromine(3,7-Dimethylxanthine) is a xanthine alkaloid that is used as a bronchodilator and as a vasodilator.
S2369 Troxerutin Troxerutin(Trihydroxyethylrutin) is a flavonol, a type of flavonoid.
S2370 Ursolic acid (Malol) Ursolic acid(Malol) is a pentacyclic triterpene acid, used in cosmetics.
S2341 Parthenolide ((-)-Parthenolide) Parthenolide ((-)-Parthenolide) is a sesquiterpene lactone which occurs naturally in the plant feverfew (Tanacetum parthenium).
S2342 Phloretin (Dihydronaringenin) Phloretin(Dihydronaringenin) is a dihydrochalcone, a type of polyphenol.
S2343 Phlorizin (Phloridzin) Phlorizin (Phloridzin) is a toxic 2’-glucoside of phloretin. It belongs to the group of dihydrochalcones, a type of flavonoids.
S2344 Piperine (1-Piperoylpiperidine) Piperine(1-Piperoylpiperidine) is the alkaloid responsible for the pungency of black pepper and long pepper, along with chavicine (an isomer of piperine). It has also been used in some forms of traditional medicine and as an insecticide.
S2346 Puerarin (Kakonein) Puerarin (Kakonein) is a 5-HT2C receptor and benzodiazepine site antagonist.
S2347 Quercetin dihydrate (Sophoretin) Quercetin, a flavonol widely distributed in plants. It is an antioxidant, like many other phenolic heterocyclic compounds.
S2349 Rutaecarpine (Rutecarpine) Rutaecarpine is an indolopyridoquinazolinone alkaloid isolated from Evodia rutaecarpa and related herbs.
S2350 Rutin (Rutoside) Rutin, a flavonol glycoside found in many plants, including buckwheat; tobacco; forsythia; hydrangea; viola, etc.
S2351 Salicin (Salicoside, Salicine) Salicin(Salicoside, Salicine) is an alcoholic β-glycoside that contains D-glucose. Salicin is an anti-inflammatory agent that is produced from willow bark.
S2324 Monensin sodium salt (Coban) Monensin sodium salt(Coban), isolated from Streptomyces cinnamonensis, is a well-known representative of naturally polyether ionophore antibiotics.
S2325 Morin hydrate (Aurantica) Morin hydrate(Aurantica) is a chemical compound. Morin can be used to test for the presence of aluminum or tin in a solution, since it forms characteristically fluorescent coordination complexes with them.
S2326 Myricetin (Cannabiscetin) Myricetin(Cannabiscetin) is a naturally occurring flavonol, a flavonoid found in many grapes, berries, fruits, vegetables, herbs, as well as other plants.
S2327 Myricitrin (Myricitrine) Myricitrin(Myricitrine) is a chemical compound. It can be isolated from the root bark of Myrica cerifera (Bayberry, a small tree native to North America) and in Chrysobalanus icaco.
S2329 Naringin (Naringoside) Naringin (Naringoside) is a flavanone glycoside and is a major flavonoid in grapefruit and gives the grapefruit juice its bitter taste.
S2330 Nattokinase Nattokinase is an enzyme extracted and purified from a Japanese food called nattō.
S2331 Neohesperidin dihydrochalcone (Nhdc) Neohesperidin dihydrochalcone(Nhdc), sometimes abbreviated to neohesperidin DC or simply NHDC, is an artificial sweetener derived from citrus.
S2333 Nobiletin (Hexamethoxyflavone) Nobiletin (Hexamethoxyflavone) is a chemical compound and an O-methylated flavone, a flavonoid isolated from citrus peels like in tangerine.
S2334 Oleanolic Acid (Caryophyllin) Oleanolic acid(Caryophyllin) is a naturally occurring triterpenoid, widely distributed in food and medicinal plants, related to betulinic acid. It is relatively non-toxic, antitumor, and hepatoprotective, as well as exhibiting antiviral.properties.
S2335 Oridonin (Isodonol) Oridonin(Isodonol), an entkaurane diterpenoid isolated from Rabdosia rubescens, is an important traditional Chinese herbal remedy.
S2336 Orotic acid (6-Carboxyuracil) Orotic acid(6-Carboxyuracil) is a heterocyclic compound and an acid.
S2337 Osthole (Osthol) Osthole(Osthol) is a type of coumarin.
S2338 Oxymatrine (Matrine N-oxide) Oxymatrine(Matrine N-oxide) is one of components of the root of Sophora flavescens.
S2339 Paeonol (Peonol) Paeonol(Peonol) is a major component extracted from Chinese herbs moutan cortex and Cynanchum paniculatum .
S2316 Kinetin (6-Furfuryladenine) Kinetin(6-Furfuryladenine) is a kind of cytokinin, a class of plant hormone that promotes cell division. Kinetin is often used in plant tissue culture for inducing formation of callus (in conjunction with auxin) and to regenerate shoot tissues from callus.
S2317 L(+)-Rhamnose Monohydrate L(+)-Rhamnose (Rham) is a naturally-occurring deoxy sugar.
S2319 Limonin Limonin is also known as limonoate D-ring-lactone and limonoic acid di-delta-lactone. Chemically, it is a member of the class of compounds known as furanolactones.
S2320 Luteolin Luteolin is a PDE4 inhibitor and a general phosphodiesterase inhibitor, and an Interleukin 6 inhibitor.
S2321 Magnolol Magnolol (2,2'-Bichavicol) is a bioactive compound found in the bark of the Houpu magnolia (Magnolia officinalis).
S2322 Matrine ((+)-Matrine) Matrine((+)-Matrine) is an alkaloid found in plants from the Sophora family. It has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor agonist.
S2323 Methyl-Hesperidin Methyl-Hesperidin is a flavanone glycoside (flavonoid) (C28H34O15) found abundantly in citrus fruits. Its aglycone form is called hesperetin.
S2304 Gramine Gramine is a naturally occurring indole alkaloid present in several plant species.
S2306 Gynostemma Extract Gynostemma Extract is a saponins extract derived from the Gynostemma pentaphyllum.
S2308 Hesperetin Hesperetin is a bioflavonoid and, to be more specific, a flavanone.
S2309 Hesperidin Hesperidin is a flavanone glycoside found abundantly in citrus fruits.
S2311 Hyodeoxycholic acid (HDCA) Hyodeoxycholic(HDCA) acid is a secondary bile acid, one of the metabolic byproducts of intestinal bacteria.
S2312 Icariin Icariin is a flavonol and PDE5 inhibitor with IC50 of 1.0, 0.75, and 1.1 μM for PDE5A1, A2, and A3, respectively.
S2313 Indole-3-carbinol Indole-3-carbinol is produced by the breakdown of the glucosinolate glucobrassicin, which can be found at relatively high levels in cruciferous vegetables.
S2314 Kaempferol Kaempferol is a natural flavonol, a type of flavonoid, that has been isolated from plant sources.
S2271 Berberine HCl Berberine Hydrochloride is a quaternary ammonium salt from the group of isoquinoline alkaloids.
S2273 β-Sitosterol β-Sitosterol is one of several phytosterols (plant sterols) with chemical structures similar to that of cholesterol.
S2276 Bilobalide Bilobalide is a biologically active terpenic trilactone present in Ginkgo biloba.
S2277 Caffeic acid Caffeic acid is a hydroxycinnamic acid, a naturally occurring organic compound.
S2280 Chlorogenic acid Chlorogenic acid is a hydroxycinnamic acid and a member of a family of naturally occurring organic compounds.
S2281 Chrysin Chrysin is a naturally occurring flavone chemically extracted from the blue passion flower (Passiflora caerulea).
S2282 Cinchonidine Cinchonidine is an alkaloid used in asymmetric synthesis in organic chemistry.
S2285 Cryptotanshinone Cryptotanshinone (CPT) is a STAT3 inhibitor with IC50 of 4.6 μM.
S2287 Cytisine (Baphitoxine, Sophorine) Cytisine is a nicotinic acetylcholine receptor agonist.
S2289 Daidzin Daidzin is a natural organic compound in the class of phytochemicals known as isoflavones.
S2290 Dihydroartemisinin (DHA) Dihydroartemisinin (DHA) is a semi-synthetic derivative of artemisinin and isolated from the traditional Chinese herb Artemisia annua.
S2291 Diosgenin Diosgenin is a steroid sapogenin and the precursor for the semisynthesis of progesterone which in turn was used in early combined oral contraceptive pills.
S2292 Diosmin Diosmin is a semisynthetic phlebotropic agent and a member of the flavonoid family.
S2294 Ecdysone Ecdysone is a steroidal prohormone of the major insect molting hormone 20-hydroxyecdysone, which is secreted from the prothoracic glands.
S2295 Emodin Emodin is a purgative resin, 6-methyl-1,3,8-trihydroxyanthraquinone, from rhubarb, the buckthorn and Japanese Knotweed (Fallopia japonica).
S2296 Enoxolone (Glycyrrhetin) Enoxolone is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrhizic acid, which was obtained from the herb liquorice.
S2297 Ergosterol Ergosterol is a sterol and a biological precursor (a provitamin) to vitamin D2.
S2298 Fisetin (Fustel) Fisetin (Fustel) is a potent sirtuin activating compound (STAC) and an agent that modulates sirtuins.
S2299 Formononetin (Formononetol) Formononetin(Formononetol) is a phytoestrogen from the root of Astragalus membranaceus and an O-methylated isoflavone.
S2300 Fumalic acid (Ferulic acid) Fumalic acid(Ferulic acid) is a hydroxycinnamic acid and a type of organic compound found in the Ferula assafoetida L. or Ligusticum chuanxiong.
S2302 Glycyrrhizic acid Glycyrrhizic acid is a widely used anti-inflammatory agent isolated from the licorice root.
S2303 Gossypol Gossypol is a polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
S2250 (-)-Epigallocatechin gallate (-)-Epigallocatechin gallate is a potent anti-oxidant polyphenol flavonoid isolated from green tea.
S2252 (+)-Usniacin (D-Usnic acid) (+)-Usniacin(D-Usnic acid) is a naturally occurring dibenzofuran derivative found in several lichen species.
S2253 3-Indolebutyric acid (IBA) 3-Indolebutyric acid(IBA) is a plant hormone in the auxin family and is an ingredient in many commercial plant rooting horticultural products.
S2256 4-Methylumbelliferone(4-MU) 4-Methylumbelliferone is a hyaluronic acid (HA) synthesis inhibitor with an IC50 of 0.4 mM.
S2258 Aesculin (Esculin) Aesculin(Esculin) is a glucoside found in horse chestnuts.
S2259 Aloe-emodin Aloe-emodin is an interferon-inducing agent with IC50 of about 1 μg/mL for JEV and of about 0.33 μg/mL for EV71.
S2260 Amygdalin Amygdalin is a glycoside initially isolated from the seeds of the tree Prunus dulcis, also known as bitter almonds.
S2261 Andrographolide Andrographolide is a labdane diterpenoid that is the main bioactive component of the medicinal plant Andrographis paniculata.
S2262 Apigenin Apigenin is a potent P450 inhibitor for CYP2C9 with IC50 of 23 pM
S2263 Arbutin (Uva, p-Arbutin) Arbutin(Uvasol, p-Arbutin) is a tyrosinase inhibitor with an IC50 of 1.09 mM.
S2265 Artesunate Artesunate is a part of the artemisinin group of agents with an IC50 of < 5 μM for small cell lung carcinoma cell line H69.
S2266 Asiatic acid Asiatic acid is the aglycone of asiaticoside isolated from the plant Centella asiatica, commonly used in wound healing.
S2267 Azomycin (2-Nitroimidazole) Azomycin(2-Nitroimidazole) is an antimicrobial antibiotic produced by a strain of Nocardia mesenterica.
S2268 Baicalein Baicalein is a CYP2C9 and prolyl endopeptidase inhibitor.
S2269 Baicalin Baicalin is a known prolyl endopeptidase inhibitor and affects the GABA receptors.
S2270 Bergenin (Cuscutin) Bergenin (Cuscutin) is trihydroxybenzoic acid glycoside and the C-glycoside of 4-O-methyl gallic acid.