Catalog No.S2425 Synonyms: Acetovanillone

2 Customer Reviews

  • Int J Endocrinol, 2016, 2016:8354745.. Apocynin purchased from Selleck.

    Treatment of rats with apocynin attenuated pancreatic morphological alterations. Representative images from the (A) sham operation (SO) group; (B) severe acute pancreatitis (SAP) group; (C) drug control (APO-CON) group; and (D) apocynin (APO) group (original magnification, ×200). (E) Pancreatic histological scores. Results are presented as the mean ± standard deviation. *P<0.05 vs. SO group; #P<0.05 vs. SAP group.

    Mol Med Rep, 2016, 14(4):3525-34.. Apocynin purchased from Selleck.

Purity & Quality Control

Biological Activity

Description Apocynin is a selective NADPH-oxidase inhibitor with IC50 of 10 μM.
NADPH-oxidase [1]
10 μM
In vitro

Apocynin is a naturally occurring methoxy-substituted catechol used as an inhibitor of NADPH-oxidase. Apocynin prevents serine phosphorylation of p47phox and blocks its association with gp91phox, thus blunting NADPH oxidase activation. [2] Apocynin can decrease the production of superoxide (O(2)(-)) from activated neutrophils and macrophages. Apocynin, after metabolic conversion, inhibits the assembly of NADPH-oxidase that is responsible for reactive oxygen species (ROS) production. [3]

In vivo Apocynin has anti-inflammatory activity in a variety of cell and animal models of inflammation. Apocynin attenuates the TNF-α and IL-1β production and iNOS expression in the lung of carrageenan-treated mice. [4] Apocynin exerts beneficial effects in a mice model of spinal cord injury. Apocynin reduces (1) the degree of spinal cord damage, (2) neutrophils infiltration, (3) ICAM-1 and P-selectin expression, (4) PAR and nitrotyrosine formation, (5) IκB-α degradation, (6) NF-κB activation, (7) pro-inflammatory cytokines production (TNF-α and IL-1β), (8) apoptosis (TUNEL staining, FAS ligand expression, Bax and Bcl-2 expression) and (9) MAPK activation (P-38 and phospho-JNK). [5] LD50: Mice 9g/kg (i.g.). [3]


Solubility (25°C)

In vitro DMSO 33 mg/mL (198.59 mM)
Ethanol 33 mg/mL (198.59 mM)
Water <1 mg/mL
In vivo 2% DMSO+30% PEG 300+ddH2O 5mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 166.17


CAS No. 498-02-2
Storage powder
in solvent
Synonyms Acetovanillone

Bio Calculators

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01402297 Completed Chronic Obstructive Pulmonary Disease Medical Universtity of Lodz|Ministry of Science and Higher Education, Poland October 2010 Phase 1
NCT00992667 Completed Bronchial Asthma Medical Universtity of Lodz|Ministry of Science and Higher Education, Poland June 2008 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID