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Rebaudioside A

Name: Rebaudioside A
Brand: Selleck Chemicals
SKU: S3796
Rating: 5 (1 reviews)

Synonyms: Reb A, Glycoside A3, Stevioside A3

Catalog No.S3796 Purity: 98%

Rebaudioside A (Stevia Extract, Reb A, Glycoside A3, Stevioside A3), an natural sweetening ingredient extracted from the stevia leaf, is used in powder or liquid form to heighten sweetening intensity and improve taste. Rebaudioside A is a steviol glycoside, α-glucosidase inhibitor with IC50 of 35.01 μg/ml.can inhibit ATP-sensitive K+-channels.

Rebaudioside A Chemical Structure

CAS: 58543-16-1

Purity & Quality Control

Batch: S379601 DMSO] 40 mg/mL] false] ] ] false] ] ] false Purity: 98%

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Biological Activity

Description	Rebaudioside A (Stevia Extract, Reb A, Glycoside A3, Stevioside A3), an natural sweetening ingredient extracted from the stevia leaf, is used in powder or liquid form to heighten sweetening intensity and improve taste. Rebaudioside A is a steviol glycoside, α-glucosidase inhibitor with IC50 of 35.01 μg/ml.can inhibit ATP-sensitive K+-channels.

In vitro
In vitro	Rebaudioside A potentiates glucose-stimulated insulin secretion on MIN6 cells. It does not shange intracellular cAMP level of isolated mouse islets. Rebaudioside A modulates the effect of glucose on insulin secretion via indirect inhibition of the KATP channels, thereby allowing β cells to depolarize and generate action potentials, events that are important for glucose-stimulated insulin secretion^[1].
Cell Research	Cell lines	MIN6 cells
	Concentrations	10^-13 to 10^-7 μM
	Incubation Time	60 min
	Method	After 30 min of preincubation with Krebs-Ringer bicarbonate buffer without glucose, cells are exposed to the indicated conditions for 60 min; the solution is then collected and subjected to radioimmunoassay for the detection of insulin levels.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT03510624	Completed	Type 2 Diabetes Mellitus	Universitaire Ziekenhuizen KU Leuven	November 9 2018	Phase 1

References

[1] Abudula R, et al. Diabetes Obes Metab. 2008, 10(11):1074-85.

Chemical Information & Solubility

Molecular Weight	967.01	Formula	C₄₄H₇₀O₂₃
CAS No.	58543-16-1	SDF	Download Rebaudioside A SDF
Smiles	CC12CCCC(C1CCC34C2CCC(C3)(C(=C)C4)OC5C(C(C(C(O5)CO)O)OC6C(C(C(C(O6)CO)O)O)O)OC7C(C(C(C(O7)CO)O)O)O)(C)C(=O)OC8C(C(C(C(O8)CO)O)O)O
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 40 mg/mL ( (41.36 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

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In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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