Gastrodin

Catalog No.S2383

Gastrodin, an anti-inflammatory polyphenol extracted from Chinese natural herbal Gastrodia elata Blume., benefits neurodegenerative diseases.

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In DMSO USD 190 In stock
USD 170 In stock
USD 320 In stock
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Gastrodin Chemical Structure

Gastrodin Chemical Structure
Molecular Weight: 286.28

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Quality Control & MSDS

Product Information

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Product Description

Biological Activity

Description Gastrodin, an anti-inflammatory polyphenol extracted from Chinese natural herbal Gastrodia elata Blume., benefits neurodegenerative diseases.
LD50
In vitro Gastrodin is the most important and effective ingredient extracted from Chinese natural herbal Gastrodia elata. Gastrodin (30, 40, and 60 mM) significantly attenuates levels of neurotoxic proinflammatory mediators and proinflammatory cytokines by inhibition of the NF-kappaB signaling pathway and phosphorylation of MAPKs in LPS-stimulated microglial cells. [1] However, It also upregulates the phosphatidylinositol 3-kinase (PI3-K)/Akt signaling, resulting in the inhibitory effects NF-kappaB and MAPKs activation in H9c2 cardiomyocytes. [2]
In vivo Gastrodin at 5 mg/kg can improve cycloheximide- and apomorphine-induced amnesia, but not scopolamine-induced acquisition impairment in rats. Thus, GAS can facilitate memory consolidation and retrieval, but not acquisition. [3] LD50: Mice >1000mg/kg (i.v.) [4]
Features

Protocol(Only for Reference)

1

References

[1] Dai JN, et al. PLoS One, 2011, 6(7), e21891.

[2] Yang P, et al. Biochem Pharmacol, 2013, 85(8), 1124-1133.

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Chemical Information

Download Gastrodin SDF
Molecular Weight (MW) 286.28
Formula

C13H18O7

CAS No. 62499-27-8
Storage 3 years -20℃Powder
6 months-80℃in DMSO
Synonyms Gastrodine
Solubility (25°C) * In vitro DMSO 50 mg/mL (174 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Research Area

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