Home Neuronal Signaling Opioid Receptor agonist (+)-Matrine For research use only.

(+)-Matrine

Matrine((+)-Matrine) is an alkaloid found in plants from the Sophora family, which has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor agonist.

(+)-Matrine Chemical Structure

(+)-Matrine Chemical Structure

CAS: 519-02-8

Selleck's (+)-Matrine has been cited by 5 publications

Purity & Quality Control

Batch: Purity: 99.72%
99.72

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Signaling Pathway

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Opioid Receptor Signaling Pathway

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Biological Activity

Description Matrine((+)-Matrine) is an alkaloid found in plants from the Sophora family, which has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor agonist.
Targets
κ-opioid receptor [1]
In vitro
In vitro Matrine((+)-Matrine) is an alkaloid found in plants from the Sophora family, which has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor agonist. Matrine significantly inhibites the growth of human non-small cell lung cancer A549 and hepatoma SMMC-7721 cells and induces apoptosis by strongly reducing the viability and the ratio of Bcl-2/Bax protein in A549 cells. [1] matrine may stimulate the descending dynorphinergic neuron, resulting in the stimulation of kappa-opioid receptors (KORs) in the spinal cord, and this phenomenon in turn produces the antinociception in mice. [2]
In Vivo
In vivo LD50: Mice 157mg/kg (i.p.) [3]

Chemical Information & Solubility

Molecular Weight 248.36 Formula

C15H24N2O
CAS No. 519-02-8 SDF Download (+)-Matrine SDF
Smiles C1CC2C3CCCN4C3C(CCC4)CN2C(=O)C1
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 50 mg/mL ( (201.32 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 50 mg/mL

Ethanol : 50 mg/mL


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In vivo
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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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