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Thymopentin Immunology & Inflammation related modulator

Cat.No.S3668

Thymopentin (TP5) has immuno-regulatory activities. The immuno-regulatory actions of thymopentin on peripheral T cells are mediated by intracellular cyclic GMP elevations in contrast to the intracellular cyclic AMP elevations induced in precursor T cells that trigger their further differentiation to T cells.
Thymopentin Immunology & Inflammation related modulator Chemical Structure

Chemical Structure

Molecular Weight: 679.77

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Quality Control

Batch: Purity: 99.87%
99.87

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (147.1 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 100 mg/mL

Ethanol : Insoluble

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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 679.77 Formula

C30H49N9O9

 Storage (From the date of receipt)
CAS No. 69558-55-0 Download SDF Storage of Stock Solutions

Synonyms TP5 Smiles CC(C)C(C(=O)NC(CC1=CC=C(C=C1)O)C(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(CCCCN)NC(=O)C(CCCN=C(N)N)N

Mechanism of Action

In vitro
TP5 displays concentration-dependent inhibitory effects on the proliferation and colony formation of HL-60 cells. the decrease or even disappearance of AgNORs from nucleoli is observed in HL-60 cells after the treatment with TP5. The suppression induced by TP5 is accompanied by an accumulation of cell cycle in the G0/G1 phase. Moreover, TP5 significantly increases the NBT-reduction activity of HL-60 cells. TP5 has induced differentiation along the granulocytes lineage in HL-60 cells. TP5 increases the expression of CD4 and CD8 markers on the surface of human thymocytes.
In vivo
TP5 is able to markedly stimulate the activity of immune system cells in healthy animals. It activates the production of a number of cytokines (IL1α, IL2, IL6, IL10, IFNγ), NO, Hsp70 and Hsp90 in mature cells of the peripheral immune system of mice (peritoneal macrophages and spleen lymphocytes).
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