Home Transmembrane Transporters Sodium Channel antagonist Veratramine For research use only.

Veratramine

Synonyms: NSC 17821, NSC 23880

Veratramine (NSC 17821, NSC 23880), a major alkaloid from Veratrum nigrum L., has distinct anti-tumor and anti-hypertension effects. It is a good membrane permeant, undergoes rapid passive diffusion, and has a good stability in the gastrointestinal tract during its absorption.

Veratramine Chemical Structure

Veratramine Chemical Structure

CAS: 60-70-8

Selleck's Veratramine has been cited by 1 publication

Purity & Quality Control

Batch: S391101 DMSO] 63 mg/mL] false] ] ] false] ] ] false Purity: 99.97%
99.97

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Signaling Pathway

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Biological Activity

Description Veratramine (NSC 17821, NSC 23880), a major alkaloid from Veratrum nigrum L., has distinct anti-tumor and anti-hypertension effects. It is a good membrane permeant, undergoes rapid passive diffusion, and has a good stability in the gastrointestinal tract during its absorption.
In vitro
In vitro Veratramine antagonizes the Na+ channel-gating mechanism of ceveratrum alkaloids by blocking Na+ channels. Veratramine also shows serotonin (5-HT) agonist activity, acting on presynaptic 5-HT neurons[1].
In Vivo
In vivo The administration of vertatramine induces generalized tremors, myoclonus, hindlimb abduction, backward gait, and Straub tail, similar to the 5-HT syndrome in mice. Veratramine causes bradycardia and periodic rhythm in the sinoatrial node of the guinea pig. The lethal dose 50% (LD50) of VAM for mice is 15.9 mg/kg with intragastrical administration [1]. Vertatramine causes DNA damage in the cerebellum and cerebral cortex of mice in a dose-dependent manner. As a major Veratrum alkaloid, veratramine (VAM) is significantly effective against hypertension by reflective inhibition of vasomotor center and tumor as an antagonist of the hedgehog signaling. Vertatramine may exert neurotoxic effects[2].
Animal Research Animal Models Kunming mice
Dosages 0.56 to 2.24 mg/kg
Administration oral ingestion

Chemical Information & Solubility

Molecular Weight 409.60 Formula

C27H39NO2
CAS No. 60-70-8 SDF Download Veratramine SDF
Smiles CC1CC(C(NC1)C(C)C2=C(C3=C(C=C2)C4CC=C5CC(CCC5(C4C3)C)O)C)O
Storage (From the date of receipt)

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DMSO : 63 mg/mL ( (153.8 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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