Home GPCR & G Protein PDE chemical Forsythin For research use only.

Forsythin

Synonyms: Phillyrin

Forsythin (FOR, Phillyrin) is an active ingredient extracted from the fruit of the medicinal plant Forsythia suspensa (Thunb.) Vahl and has been shown to have antioxidant, antibacterial and antiinflammatory properties.

Forsythin Chemical Structure

Forsythin Chemical Structure

CAS: 487-41-2

Purity & Quality Control

Batch: Purity: 99.89%
99.89

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Biological Activity

Description Forsythin (FOR, Phillyrin) is an active ingredient extracted from the fruit of the medicinal plant Forsythia suspensa (Thunb.) Vahl and has been shown to have antioxidant, antibacterial and antiinflammatory properties.
In Vivo
In vivo The results of acute toxicity tests in mice reveal that the maximum-tolerated dose (MTD) of forsythin is greater than 18 100 mg/kg. In the sub-chronic toxicity tests in rats, the no-observed-adverse-effect-level (NOAEL) is observed after 30 days at the concentration of 6480 mg/kg body weight. The use of forsythin in vivo is safe[1].
Animal Research Animal Models SD rats (150-200 g)
Dosages 0, 540, 1620, and 6480 mg/kg
Administration oral administration

Chemical Information & Solubility

Molecular Weight 534.55 Formula

C27H34O11
CAS No. 487-41-2 SDF --
Smiles COC1=C(C=C(C=C1)C2C3COC(C3CO2)C4=C(C=C(C=C4)OC5C(C(C(C(O5)CO)O)O)O)OC)OC
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (187.07 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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