Apigenin Chemical Structure
Voriconazole (VFEND) is a triazole antifungal medication that is generally used to treat serious, invasive fungal infections.
Cytochrome P450 14a-demethylase inhibitor 1a is an antifungal agent and an analog of fluconazole with an MIC80 of 3.9 ng/ml against Candida albicans.
Cytochrome P450 14a-demethylase inhibitor 1b is an antifungal agent and an analog of fluconazole with an MIC80 of 3.9 ng/ml against Candida albicans and Microsporum gypseum.
Cytochrome P450 14a-demethylase inhibitor 1c is an antifungal agent and an analog of fluconazole with an MIC80 of 15.6 ng/ml against Candida albicans and Microsporum gypseum.
Cytochrome P450 14a-demethylase inhibitor 1d is an antifungal agent and an analog of fluconazole with an MIC80 of 15.6 ng/ml against Candida albicans and Microsporum gypseum.
Cytochrome P450 14a-demethylase inhibitor 1e is an antifungal agent and an analog of fluconazole with an MIC80 of 15.6 ng/ml against Candida albicans.
Cytochrome P450 14a-demethylase inhibitor 1f is an antifungal agent and an analog of fluconazole with an MIC80 of 15.6 ng/ml against Candida albicans.
Cytochrome P450 14a-demethylase inhibitor 1g is an antifungal agent and an analog of fluconazole with an MIC80 of 0.25 µg/ml against Candida albicans.
Cytochrome P450 14a-demethylase inhibitor 1h is an antifungal agent and an analog of fluconazole with an MIC80 of 15.6 ng/ml against Microsporum gypseum.
Cytochrome P450 14a-demethylase inhibitor 1i is an antifungal agent and an analog of fluconazole with an MIC80 of 62.5 ng/ml against Candida albicans.
Apigenin is a potent CYP2C9 inhibitor with an IC50 of 23 pM. CYP2C9 is an enzyme responsible for the metabolism of many pharmaceutical compounds in the body. Apigenin is commonly recognised as to mediate at least part of the chemopreventive action of vegetables and fruits in the cancerous process. Recently it was shown that apigenin induces a process called autophagia (a kind of cellular dormancy) which may well explain it chemopreventive properties but at the same time induces resistance against chemotherapy. Apigenin is a flavone that is the aglycone of several glycosides. [1][2]
| Molecular Weight (WM): | 270.24 |
|---|---|
| Formula: | C15H10O5 |
| CAS No.: | 520-36-5 |
| Synonyms: |
N/A
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| Dissolve in (25°C): | DMSO ≥54mg/mL |
| Water <1mg/mL | |
| Ethanol <1mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
A collection of 864 bioactive compounds
A collection of 481 inhibitors
A collection of 194 kinase inhibitors
A collection of 85 tyrosine kinase inhibitors.
A collection of 426 FDA approved drugs
A collection of 139 natural products
A collection of 40 chemotherapeutic agents
A unique collection of 17 small molecule modulators
A unique collection of 47 small molecule inhibitors
A unique collection of 63 GPCR small molecules
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