Chaetocin

Catalog No.S8068

Chaetocin Chemical Structure

Molecular Weight(MW): 696.84

Chaetocin, a natural product from Chaetomium species, is a histone methyltransferase inhibitor with IC50 of 0.8 μM, 2.5 μM and 3 μM for dSU(VAR)3-9, mouse G9a and Neurospora crassa DIM5, respectively.

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Biological Activity

Description Chaetocin, a natural product from Chaetomium species, is a histone methyltransferase inhibitor with IC50 of 0.8 μM, 2.5 μM and 3 μM for dSU(VAR)3-9, mouse G9a and Neurospora crassa DIM5, respectively.
Targets
dSU(VAR)3-9 [1] mouse G9a [1] Neurospora crassa DIM5 [1]
0.8 μM 2.5 μM 3 μM
In vitro

In SL-2 Drosophila tissue culture cells, Chaetocin causes the inhibition of SU(VAR)3-9 and the number of H3 molecules dimethylated at Lys9, and also inhibits cell growth. [1] In HepG2, Hep3B, and Huh7 human hepatoma cells, Chaetocin inhibits HIF-1-Mediated hypoxic responses. [2] Chaetocin also potently inhibits proliferation and colony formation in a broad range of cancer cell lines with IC50 of 2-10 nM. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A549 cells Mn;JR5l1d3SxeHnjbZR6KGG|c3H5 MWDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzMEBKSzVyPUCuNFI2KM7:TR?= M4rnTFIxOzB|N{[3
Hep3b cells NV;IdWd6TnWwY4Tpc44h[XO|YYm= MlnITY5pcWKrdHnvckBw\iCKSV[tNYFteGijLX3l[IlifGWmIG\FS2Yh\XiycnXzd4lwdiCrbjDoeY1idiCKZYCzZkBk\WyuczDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFnDOVA:OC5yNDFOwG0> NELIbZIzOjNyNU[xNi=>
Jurkat cells MWnDfZRwfG:6aXPpeJkh[XO|YYm= M2DOSFQxKGh? M3vVbWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGp2emujdDDj[YxteyCjZoTldkA1OCCqcoOgZolwdHWvaX7ld4NmdmOnIHHzd4F6NCCLQ{WwQVAvPiEQvF2= M4rXXVIxOzB|N{[3
HL60 cells NWDadGJPTnWwY4Tpc44h[XO|YYm= NYnQ[HR3OC5|IIXN MXW0JIg> MmHOTY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDoeY1idiCKTE[wJINmdGy|IHHzd4V{e2WmIHHzJI52[2ynYYKg[pJi\22nboTheIlwdiCjdDCwMlMhfU1iYX\0[ZIhPCCqcoOgeZNqdmdiRFHQTU9RUSCkeTDjc45nd2OjbDDsZZNmeiCvaXPyc5Nkd3C7IHHuZYx6e2m| NV\kdGFDOjB4N{WxN|E>

... Click to View More Cell Line Experimental Data

In vivo In Hepa 1c1c-7 tumor-bearing mice, Chaetocin (0.25 mg/kg, i.p.) inhibits tumor growth by deregulating HIF-1[alpha]-mediated angiogenesis. [2] In SKOV3 tumor-bearing nude mice, chaetocin treatment (0.25 mg/kg, i.p.) significantly delays the tumor growth with minimal evidence of toxicities. [3]

Protocol

Animal Research:[2]
+ Expand
  • Animal Models: Hur7 tumor-bearing mice, Hepa 1c1c-7 tumor-bearing mice
  • Formulation: DMSO
  • Dosages: 0.25 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL warmed (143.5 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 696.84
Formula

C30H28N6O6S4

CAS No. 28097-03-2
Storage powder
Synonyms N/A

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Related Antibodies

Histone Methyltransferase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID