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Allantoin

Cat.No.S3856

Allantoin (Glyoxyldiureide, 5-Ureidohydantoin), produced from uric acid, is a major metabolic intermediate in most organisms including animals, plants and bacteria.
Allantoin Chemical Structure

Chemical Structure

Molecular Weight: 158.12

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Quality Control

Batch: Purity: 99.94%
99.94

Solubility

In vitro
Batch:

DMSO : 7 mg/mL (44.27 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

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In vivo
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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 158.12 Formula

C4H6N4O3

 Storage (From the date of receipt)
CAS No. 97-59-6 -- Storage of Stock Solutions

Synonyms Glyoxyldiureide, 5-Ureidohydantoin Smiles C1(C(=O)NC(=O)N1)NC(=O)N

Mechanism of Action

In vivo
The subchronic administration of allantoin (1, 3 or 10 mg/kg, for 7 days) significantly increases the latency time measured during the passive avoidance task in scopolamine-induced cholinergic blockade and normal naïve mice. This compound treatment (3 or 10 mg/kg, for 7 days) also increases the expression levels of phosphorylated phosphatidylinositide 3-kinase (PI3K), phosphorylated protein kinase B (Akt) and phosphorylated glycogen synthase kinase-3β (GSK-3β). It has memory-enhancing effects, and these effects may be partly mediated by the PI3K-Akt-GSK-3β signal pathway.
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06338410 Completed
Kangaroo Mother Care|Oxidative Stress
University of Health Sciences Lahore|Services Hospital Lahore
 August 1 2023 Not Applicable
NCT04325490 Completed
Intertrigo
Mahidol University|HOE pharmaceuticals Sdn. Bhd.
 October 1 2019 Phase 4
NCT04046783 Completed
Cesarean Section; Dehiscence|Scar Keloid|Wound Heal
University of Salerno
 March 2 2019 --
NCT03849677 Completed
Healthy|Diet Modification
Erasme University Hospital|Fonds National de la Recherche Scientifique|Fonds Erasme|Fonds pour la chirurgie cardiaque
 March 10 2019 --
NCT03631394 Completed
Exercise
Loma Linda University
 September 1 2018 Not Applicable

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