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Tannic acid

Synonyms: Gallotannic acid

Tannic acid (Gallotannic acid), a polyphenolic compound, is a CXCL12/CXCR4 inhibitor with antiangiogenic, anti-inflammatory and antitumor activity.

Tannic acid Chemical Structure

Tannic acid Chemical Structure

CAS: 1401-55-4

Purity & Quality Control

Batch: Purity: 99%
99

Tannic acid Related Products

Signaling Pathway

CXCR Signaling Pathways

CXCR Signaling Pathway

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Cell Data

Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CHO Function assay Ki values for sodium fluorescein (10 uM) uptake in OATP1B1-transfected CHO cells, Ki = 1.46 μM. 23571415
CHO Function assay pIC50 values for sodium fluorescein (10 uM) uptake in OATP1B1-transfected CHO cells, IC50 = 2.63027 μM. 23571415
CHO Function assay Ki values for sodium fluorescein (10 uM) uptake in OATP1B3-transfected CHO cells, Ki = 3.23 μM. 23571415
CHO Function assay pIC50 values for sodium fluorescein (10 uM) uptake in OATP1B3-transfected CHO cells, IC50 = 4.16869 μM. 23571415
Click to View More Cell Line Experimental Data

Biological Activity

Description Tannic acid (Gallotannic acid), a polyphenolic compound, is a CXCL12/CXCR4 inhibitor with antiangiogenic, anti-inflammatory and antitumor activity.
Targets
CXCR4 [1]
In vitro
In vitro Tannic acid, at nontoxic concentrations, specifically inhibits CXCL12-induced human monocyte migration (IC50, 7.5 μg/ml) but does not inhibit CCL2-, CCL3-, CCL5-, formylmethionylleucylphenylalanine (fMLP)-, or C5a-induced migration. The compound markedly blocks CXCL12 binding to THP-1 cells (IC50, 0.36 μg/ml). Tannic acid also inhibits CXCL12-induced, but not epidermal growth factor-induced, migration of MDA 231 breast tumor cells. Additionally, 0.5 μg/ml of tannic acid selectively inhibits CXCL12-mediated, but not basic fibroblast growth factor- or endothelial cell growth supplement-mediated, bovine aorta endothelial cell capillary tube formation[1].
Cell Research Cell lines THP-1 cells or BAEC cells
Concentrations 0-100 μg/ml
Incubation Time 24 h
Method Freshly isolated human monocytes, THP-1 cells or BAEC cells, are plated into 96-microwell plates at 1 × 105 cells/well in the presence of tannic acid at a final concentration of 100 μg/ml. Cell viability is determined by [3H]thymidine incorporation (THP-1 cells and BAEC cells) or trypan blue exclusion (human monocytes), 24 h after coincubation at 37°C in humidified air with 5% CO2.
In Vivo
In vivo Given in drinking water, tannic acid enhances the survival rate of mice bearing syngeneic tumors[1].

Chemical Information & Solubility

Molecular Weight 1701.2 Formula

C76H52O46
CAS No. 1401-55-4 SDF Download Tannic acid SDF
Smiles C1=C(C=C(C(=C1O)O)O)C(=O)OC2=CC(=CC(=C2O)O)C(=O)OCC3C(C(C(C(O3)OC(=O)C4=CC(=C(C(=C4)OC(=O)C5=CC(=C(C(=C5)O)O)O)O)O)OC(=O)C6=CC(=C(C(=C6)OC(=O)C7=CC(=C(C(=C7)O)O)O)O)O)OC(=O)C8=CC(=C(C(=C8)OC(=O)C9=CC(=C(C(=C9)O)O)O)O)O)OC(=O)C1=CC(=C(C(=C1)OC(=O)C1=CC(=C(C(=C1)O)O)O)O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 94 mg/mL ( (55.25 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 94 mg/mL

Ethanol : 50 mg/mL


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In vivo
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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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