Osthole

Catalog No.S2337 1 Product Citations

Osthol is an O-methylated coumarin, which is found in the plants such as Cnidium monnieri, Angelica archangelica and Angelica pubescens.

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In DMSO USD 70 In stock
USD 50 In stock
USD 170 In stock
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Osthole Chemical Structure

Osthole Chemical Structure
Molecular Weight: 244.29

Validation & Quality Control

Quality Control & MSDS

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Product Description

Biological Activity

Description Osthol is an O-methylated coumarin, which is found in the plants such as Cnidium monnieri, Angelica archangelica and Angelica pubescens.
LD50
In vitro Osthol is an O-methylated coumarin which is found in the plants such as Cnidium monnieri, Angelica archangelica and Angelica pubescens. Osthol inhibites platelet aggregation and ATP release induced by ADP, arachidonic acid, PAF, collagen, ionophore A23187 and thrombin in washed rabbit platelets. [1] Osthole mediates cell differentiation through bone morphogenetic protein-2/p38 and extracellular signal-regulated kinase 1/2 pathway in human osteoblast cells and may be a promising agent for treating osteoporosis. [2] Osthole also suppresses the secretion of hepatitis B virus in cell culture by increasing the glycosylation of HBsAg. [3]
In vivo LD50: Rats >125mg/kg (i.v.); Rabbits >35mg/kg (i.v.); Dogs >150mg/kg (i.v.). [4]
Features

Protocol(Only for Reference)

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesBaboonDogMonkeyRabbitGuinea pigRatHamsterMouse
Weight (kg)121031.80.40.150.080.02
Body Surface Area (m2)0.60.50.240.150.050.0250.020.007
Km factor202012128653
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

References

[1] Ko FN, et al. Thromb Haemost, 1989, 62(3), 996-999.

[2] Kuo PL, et al. J Pharmacol Exp Ther, 2005, 314(3), 1290-1299.

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Chemical Information

Download Osthole SDF
Molecular Weight (MW) 244.29
Formula

C15H16O3

CAS No. 484-12-8
Storage 3 years -20℃Powder
6 months-80℃in DMSO
Synonyms Osthol
Solubility (25°C) * In vitro DMSO 49 mg/mL (200 mM)
Water <1 mg/mL (<1 mM)
Ethanol 49 mg/mL (200 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Research Area

Product Citations (1)

Tech Support & FAQs

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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